Seizure burden and neurodevelopmental outcome in newborns with hypoxic-ischemic encephalopathy treated with therapeutic hypothermia: A single center observational study

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Hypoxic ischemic encephalopathy (HIE) occurs in 1–8 newborns per 1000 live births and it is the most common cause of seizures in term neonates. [1] Many studies in asphyxiated neonates before the advent of therapeutic hypothermia [TH] have shown a relationship between clinical and/or electrographic seizures, especially status epilepticus, and abnormal outcome. [2] Due to the overlapping between the ischemic hypoxic damage and the injury resulting from seizures activity, it is still difficult to establish the impact of seizures in the exacerbation of brain damage and in the worsening outcome of asphyxiated newborns [3].

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