Exploring the crosstalk of glycolysis and mitochondrial metabolism in psychiatric disorders and brain tumors



Dysfunction of metabolic pathways characterizes a plethora of common pathologies and has emerged as a core underlying characteristic of disease phenotypes. Here, we focus on psychiatric disorders and brain tumors and explore changes in the interplay between glycolysis and mitochondrial energy metabolism in the brain. We discuss alterations in glycolysis vs. core mitochondrial metabolic pathways, such as the tricarboxylic acid cycle and oxidative phosphorylation, in major psychiatric disorders and brain tumors. We investigate potential common patterns of altered mitochondrial metabolism in different brain regions and cell types and explore how changes in mitochondrial number, shape and morphology affect disease‐related manifestations. We also highlight the potential of pharmacologically targeting mitochondria to achieve therapeutic effects.


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