Identification of the laterality of motor unit behavior in female patients with parkinson’s disease using high‐density surface electromyography

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Identification of the laterality of motor unit behavior in female patients with parkinson's disease using high‐density surface electromyography

Parkinson’s disease patients have greater laterality of muscle contraction properties than other parkinsonian diseases. This study demonstrated that identify the laterality of motor unit behavior in Parkinson’s disease patients using high‐density surface electromyography. From high‐density surface electromyography signals, individual motor unit behavior firing patterns were decomposed using the Convolution Kernel Compensation technique. Our findings showed that this technique can detect laterality of motor unit behavior and experience motor unit behavioral abnormalities even with mild symptoms.

Abstract

Patients with Parkinson’s disease (PD) have greater laterality of muscle contraction properties than other people with parkinsonism diseases. However, few studies have reported the laterality of MU activation properties of the lower extremity muscles in patients with PD. The aim of the present study was to identify the laterality of MU behavior in PD patients using high‐density surface electromyography (HD‐SEMG). Eleven female patients with PD (age, 69.2 ± 6.2 years, disease duration, 2.7 ± 0.9 years, Unified Parkinson’s disease Rating Scale score, 13 (9–16)), and 9 control female subjects (age, 66.8 ± 3.5 years) were enrolled in the present study. All subjects performed a sustained isometric knee extension in a 30% maximal voluntary contraction (MVC) task for 20 s. HD‐SEMG signals were used to record and extract single MU firing behavior in the vastus lateralis muscle during submaximal isometric knee extensor contractions with 64 electrodes and decomposed with the convolution kernel compensation technique to extract individuals MUs. Compared to the control subjects, the patients with PD exhibited laterality of the MU firing rate and an absence of a relationship between the mean MU firing rate and MU threshold. Patients with PD exhibit laterality of MU behavior and experience MU behavioral abnormalities even with mild symptoms such as Hoehn & Yahr stage ≤ 3 and disease duration = 2.7 ± 0.9. These findings suggest the importance of considering the detection of abnormal muscle properties in PD patients beginning in the early phase of the disease.

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