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Browsing Category
Neuroscience
Age-Related Deficits in Electrophysiological and Behavioral Measures of Binaural Temporal Processing
Binaural processing, particularly the processing of interaural phase differences, is important for sound localization and speech understanding in background noise. Age has been shown to impact the neural encoding and perception of these…
Rapid Estrogenic and Androgenic Neurosteroids Effects in the Induction of Long-Term Synaptic…
Mounting experimental evidence demonstrate that sex neuroactive steroids (neurosteroids) are essential for memory formation. Neurosteroids have a profound impact on the function and structure of neural circuits and their local synthesis is…
Human iPSC-Derived Neuronal Cells From CTBP1-Mutated Patients Reveal Altered Expression of…
A recurrent de novo mutation in the transcriptional corepressor CTBP1 is associated with neurodevelopmental disabilities in children (Beck et al., 2016, 2019; Sommerville et al., 2017). All reported patients harbor a single recurrent de…
Basal Forebrain Cholinergic Activity Modulates Isoflurane and Propofol Anesthesia
Cholinergic neurons in the basal forebrain (BF) have long been considered to be the key neurons in the regulation of cortical and behavioral arousal, and cholinergic activation in the downstream region of the BF can arouse anesthetized…
Predicting Sex From EEG: Validity and Generalizability of Deep-Learning-Based Interpretable…
Explainable artificial intelligence holds a great promise for neuroscience and plays an important role in the hypothesis generation process. We follow-up a recent machine learning-oriented study that constructed a deep convolutional neural…
Hedgehog signaling regulates neurogenesis in the larval and adult zebrafish hypothalamus
Male, I., Ozacar, A. T., Fagan, R. R., Loring, M. D., Loring, M. D., Shen, M.-C., Pace, V. A., Devine, C. A., Lawson, G. E., Lutservitz, A., Karlstrom, R. O.
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Neurogenesis is now known to play a role in adult hypothalamic function, yet the cell-cell mechanisms regulating this neurogenesis remain poorly understood. Here we show that Hedgehog/Gli signaling positively regulates hypothalamic…
Traumatic brain injury diminishes feedforward activation of parvalbumin-expressing interneurons in…
Traumatic brain injury (TBI) is associated with aberrant network hyperexcitability in the dentate gyrus. GABAAergic parvalbumin-expressing interneurons (PV-INs) in the dentate gyrus regulate network excitability with strong, perisomatic…
Modeling neurodegeneration in Caenorhabditis elegans [AT A GLANCE]
ABSTRACT
The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors. The nematode Caenorhabditis elegans has served as the experimental…
Cortical projection from the premotor or primary motor cortex to the subthalamic nucleus in intact…
Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and…