Browsing Tag

1p/19q co-deletion

Pituitary-Tumor Endocrinopathies

Pituitary adenomas account for approximately 15% of intracranial tumors. Management of these benign tumors requires diagnosis of the specific intrasellar disease and comprehensive, multidisciplinary treatment of local mass effects and…

Medical Marijuana Miscalculation

To the Editor: Pennsylvania legalized medical marijuana in 2016, and since then its use has skyrocketed. The doses of the active ingredients of marijuana — tetrahydrocannabinol (THC) and cannabidiol (CBD) — are not standardized, product…

Bearing Witness

You can’t walk into a pediatric intensive care unit (PICU) anywhere in the world without being viscerally struck by sights, smells, and sounds that can easily overwhelm the uninitiated. Every child in a PICU is attached to various monitors…

Steering CAR T Cells into Solid Tumors

Chimeric antigen receptor (CAR) T cells have been strikingly successful in the treatment of hematologic cancers but have not been effective against solid tumors thus far. A recent report by Samaha and colleagues presents a preclinical…

Neuroblastoma and Histone Demethylation

Neuroblastoma is a childhood cancer of the sympathetic nervous system, with a propensity for widespread metastasis and aggressive clinical behavior. For patients with so-called high-risk disease (typically patients 18 months of age or older…