Browsing Tag

antiepileptic

Reduced expression of the glucocorticoid receptor in the hippocampus of patients with drug‐resistant…

Abstract Objective Depressive disorders are common among about 50% of the patients with drug‐resistant temporal lobe epilepsy (TLE). The underlying etiology remains elusive, but hypothalamus‐pituitary‐adrenal (HPA) axis activation due to…

Photoplethysmographic evaluation of generalized tonic‐clonic seizures

Abstract Objective Photoplethysmography (PPG) is an optical technique measuring variations of blood perfusion in peripheral tissues. We evaluated alterations in PPG signals in relationship to the occurrence of generalized tonic‐clonic…

Assessment of the long‐term efficacy and safety of adjunctive perampanel in tonic‐clonic seizures:…

Abstract Objective This post hoc analysis evaluated long‐term efficacy and safety in patients with focal to bilateral tonic‐clonic seizures (FBTCS) or generalized tonic‐clonic seizures (GTCS) who entered open‐label extension (OLEx) studies…

P‐glycoprotein overactivity in epileptogenic developmental lesions measured in vivo using…

Abstract Objective Overexpression of the drug transporter P‐glycoprotein (P‐gp) is thought to be involved in drug‐resistance in epilepsy by extrusion of antiepileptic drugs (AEDs). We used positron emission tomography (PET) and the P‐gp…