Browsing Tag

neurology

General Neurology

Causal associations between modifiable risk factors and the Alzheimer’s phenome

Shea J Andrews, Brian Fulton‐Howard, Paul O’Reilly, Edoardo Marcora, Alison M Goate, collaborators of the Alzheimer’s Disease Genetics Consortium, Lindsay A Farrer, Jonathan L Haines, Richard Mayeux, Adam C Naj, Margaret A Pericak‐Vance, Gerard D Schellenberg, Li‐San Wang 0
Objective To infer causal relationships between 22 previously reported risk factors for Alzheimer’s disease (AD) and the “AD phenome”: AD, AD age of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid…
General Neurology

A stearoyl‐CoA desaturase inhibitor prevents multiple Parkinson’s disease‐phenotypes in…

Silke Nuber, Alice Y Nam, Molly M Rajsombath, Haley Cirka, Xiaoping Hronowski, Junmin Wang, Kevin Hodgetts, Liubov S Kalinichenko, Christian P Müller, Vera Lambrecht, Jürgen Winkler, Andreas Weihofen, Thibaut Imberdis, Ulf Dettmer, Saranna Fanning, Dennis J Selkoe 0
Objective Parkinson's disease (PD) has useful symptomatic treatments that do not slow the neurodegenerative process, and no significant disease‐modifying treatments are approved. A key therapeutic target in PD is α‐synuclein (αS), which is…
General Neurology

Prior anticoagulation in patients with ischaemic stroke and atrial fibrillation

Thomas R Meinel, Mattia Branca, Gian Marco De Marchis, Krassen Nedeltchev, Timo Kahles, Leo Bonati, Marcel Arnold, Mirjam R Heldner, Simon Jung, Emmanuel Carrera, Elisabeth Dirren, Patrik Michel, Davide Strambo, Carlo W Cereda, Giovanni Bianco, Georg Kägi, Jochen Vehoff, Mira Katan, Manuel Bolognese, Roland Backhaus, Stephan Salmen, Sylvan Albert, Friedrich Medlin, Christian Berger, Ludwig Schelosky, Susanne Renaud, Julien Niederhauser, Christophe Bonvin, Michael Schaerer, Marie‐Luise Mono, Biljana Rodic, Alexander A Tarnutzer, Pasquale Mordasini, Jan Gralla, Johannes Kaesmacher, Stefan Engelter, Urs Fischer, David J Seiffge, the Investigators of the Swiss Stroke Registry, Philippe Lyrer, Nils Peters, Alexandros Polymeris, Sebastian Thilemann, Valerian Altersberger, Kristin Blackham, Tolga Dittrich, Amgad El Mekabaty, Joachim Fladt, Urs Fisch, Hernik Gensicke, Lisa Hert, Sabrina Manuzzi, Marios Psychogios, Marina Maurer, Christopher Traenka, Ioannes Tsogkas, Benjamin Wagner, Anaella Zietz, Alex Brehm, Louisa Meya, Hakan Sarikaya, Martina Goeldlin, Jan Vynckier, Basel Mamaari, Bernhard Siepen, Madlaine Mueller, Ashraf Eskandari, Vasiliki Pantazou, Susanne Wegener, Achim Mueller, Valerie Schütz, Thomas Pokorny, Andreas Luft, Sylvan Albert, Rolf Sturzenegger, Andrea Humm, David Cuendet, Ettore Accolla, Jean‐Marie Annoni, Sandrine Foucras, Katharina Klahre Minkner, Philippe Olivier, Peter Kelemen, Gabriele Brodo, Maria Cordier, Vaiva Jurgutiene, Guillermo Toledo Sotomayor, Loraine Fisch 0
Objective To evaluate in patients with atrial fibrillation (AF) and acute ischaemic stroke the association of prior anticoagulation with vitamin‐K antagonists (VKA) or direct oral anticoagulants (DOACs) with stroke severity, intravenous…