Browsing Tag

neuropathology

Astrocyte–microglial association and matrix composition are common events in the natural history of…

Abstract Primary familial brain calcification (PFBC) is an age‐dependent and rare neurodegenerative disorder characterized by microvascular calcium phosphate deposits in the deep brain regions. Known genetic causes of PFBC include…

Ki‐67 and MCM6 labeling indices are correlated with overall survival in anaplastic…

Abstract Anaplastic oligodendroglioma (AO), IDH‐mutant and 1p/19q codeleted (IDHmut+/1p19qcodel), is a high‐grade glioma with only limited prognostic markers. The primary objective of this study was to evaluate, by immunohistochemistry, the…

BRAF V600E mutant oligodendroglioma‐like tumors with chromosomal instability in adolescents and…

Abstract We performed genome‐wide methylation analysis on 136 pediatric low‐grade gliomas, identifying a unique cluster consisting of three tumors with oligodendroglioma‐like histology, BRAF p.V600E mutations and recurrent whole chromosome…

Reduction in the neuronal surface of post and presynaptic GABAB receptors in the hippocampus in a…

Abstract The hippocampus plays key roles in learning and memory and is a main target of Alzheimer's disease (AD), which causes progressive memory impairments. Despite numerous investigations about the processes required for the normal…