Browsing Tag

neuropathology

High level MYCN amplification and distinct methylation signature define an aggressive subtype of…

We report a novel group of clinically aggressive spinal cord ependymomas characterized by Grade III histology, MYCN amplification, an absence of NF2 alterations or other recurrent pathogenic mutations, and a uniq...

Neuropathological profile of long duration amyotrophic lateral sclerosis in military Veterans

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder affecting both the upper and lower motor neurons. Although ALS typically leads to death within 3 to 5 years after initial symptom onset, approximately…

Disturbed balance in the expression of MMP9 and TIMP3 in cerebral amyloid angiopathy-related…

Cerebral amyloid angiopathy (CAA) is characterized by the deposition of the amyloid β (Aβ) protein in the cerebral vasculature and poses a major risk factor for the development of intracerebral haemorrhages (I...