admin September 4, 2017
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Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study.

J Nucl Med. 2017 Aug 28;:

Authors: Mauler J, Maudsley AA, Langen KJ, Nikoubashman O, Stoffels G, Sheriff S, Lohmann P, Filss C, Galldiks N, Rota Kops E, Shah NJ

Abstract
PET imaging of amino acid transport using O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) and proton MRS imaging of cell turnover measured by the choline to N-acetyl-aspartate (Cho/NAA) ratio may provide additional information on tumor extent of cerebral gliomas compared to anatomical imaging; however, comparative studies are rare. Methods. In this prospective study, 41 patients (w/m=16/25, 48±14 years old) with cerebral gliomas (grade WHO II: 10 (incl. one patient with two lesions), WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid-PET-MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in FET PET and MRSI Cho/NAA, determined by simultaneously acquired, 3D spatially resolved MR spectroscopic imaging data were compared. Results. The average tumor volumes for FET uptake and increased Cho/NAA were 19±20 cm(3) and 22±24 cm(3), respectively, with an overlap of 40±25% and separation of the centers of gravity by 9±8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion. FET uptake and increased Cho/NAA-ratio may represent different properties of glioma metabolism and the relationship to histological tumor extent needs to be further analyzed.

PMID: 28848036 [PubMed – as supplied by publisher]

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