Spatial Relationship of Glioma Volume Derived from FET PET and Volumetric MRSI: a hybrid PET-MRI study.
J Nucl Med. 2017 Aug 28;:
Authors: Mauler J, Maudsley AA, Langen KJ, Nikoubashman O, Stoffels G, Sheriff S, Lohmann P, Filss C, Galldiks N, Rota Kops E, Shah NJ
PET imaging of amino acid transport using O-(2-[(18)F]fluoroethyl)-L-tyrosine (FET) and proton MRS imaging of cell turnover measured by the choline to N-acetyl-aspartate (Cho/NAA) ratio may provide additional information on tumor extent of cerebral gliomas compared to anatomical imaging; however, comparative studies are rare. Methods. In this prospective study, 41 patients (w/m=16/25, 48±14 years old) with cerebral gliomas (grade WHO II: 10 (incl. one patient with two lesions), WHO III: 17, WHO IV: 13, without biopsy low-grade: 1, high-grade: 1) were investigated with a hybrid-PET-MR scanner. Tumor extent, spatial overlap, and the distance between the corresponding centers of mass in FET PET and MRSI Cho/NAA, determined by simultaneously acquired, 3D spatially resolved MR spectroscopic imaging data were compared. Results. The average tumor volumes for FET uptake and increased Cho/NAA were 19±20 cm(3) and 22±24 cm(3), respectively, with an overlap of 40±25% and separation of the centers of gravity by 9±8 mm. None of the parameters showed a significant correlation with tumor grade. Conclusion. FET uptake and increased Cho/NAA-ratio may represent different properties of glioma metabolism and the relationship to histological tumor extent needs to be further analyzed.
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