Grade 2 gliomas are relatively uncommon, constituting 5 to 10% of all primary brain tumors in adults. Progressive neurologic symptoms eventually develop in nearly all patients, and nearly all patients die prematurely. At the time of the initiation of our trial, studies had shown that chemotherapy…

Presentation of Case. Dr. Ivana Vodopivec (Neurology): A 32-year-old man was seen in an outpatient clinic of this hospital because of olfactory hallucinations, intermittent numbness and paresthesias on the left side, and a mass in the right temporal lobe. The patient had been well until…

Presentation of Case. Dr. Laura E. Dichtel (Endocrinology): A 20-year-old man was evaluated at this hospital because of gynecomastia. The patient came to the hospital for a routine annual examination to establish adult care. He reported a 3-year history of bilateral breast enlargement, with no…

To the Editor: The genomic landscape of lower-grade gliomas has recently been investigated in “multi-omic” analyses that have revealed molecular subgroups with prognostic relevance. In particular, robust biomarkers, including 1p/19q codeletion (deletion of chromosome arms 1p and 19q), IDH mutation,…

Presentation of Case. Dr. Andrew S. Chi: A 52-year-old woman with a history of oligodendroglioma was seen in the outpatient neuro-oncology clinic of this hospital for routine follow-up. Twelve years earlier, the patient presented with a generalized tonic–clonic seizure 4 days after she had…

Glioblastoma, an aggressive primary brain tumor, is among the most lethal of human cancers. We present evidence of the potential therapeutic benefit of adoptive T-cell therapy against glioblastoma with the use of CAR-engineered T cells targeting IL13Rα2, a glioma-associated antigen linked to a…

Glioblastoma is a fatal illness that is associated with a median survival of less than 2 years. Population studies of glioblastoma have shown that survival declines with increasing age, and the incidence of glioblastoma is increasing, especially among the elderly. Older patients have been…

Figure 1.

Figure 1.

“Hospice. It’s where people go to die,” she says, surprising me with her sudden lucidity. “And also for symptom management,” I add gently. “Like my headache,” she notes. And your homelessness, I think — the fact that your one-bedroom, upstairs council flat just won’t do anymore.… Read More...