Epilepsy

Jo Sourbron, Michèle Partoens, Chloë Scheldeman, Yifan Zhang, Lieven Lagae, Peter Witte January 21, 2019

Summary

Dravet syndrome (DS) is a severe genetic epileptic encephalopathy with onset during the first year of life. Zebrafish models recapitulating human diseases are often used as drug discovery platforms, but also for drug repurposing testing. It was recently shown that pharmacological modulation of three serotonergic (5‐HT) receptors (5‐HT1D, 5‐HT2C, 5‐HT2A) exerts antiseizure effects in a zebrafish scn1Lab

−/−
mutant model of DS.… Read More...

Lars‐Olov Brorson, Mats Eriksson, Karin Blomberg, Erik Stenninger January 21, 2019

Summary

Objective

To describe the long‐term prognosis of childhood epilepsy, with special emphasis on seizure remission, relapse, medication, associated neurologic impairment, mortality rate, and cause of death.

Methods

A prospective longitudinal study on a population‐based total cohort of 195 children with epileptic seizures in 1962‐1964.… Read More...

Shinsaku Yoshitomi, Yukitoshi Takahashi, Katsumi Imai, Eriko Koshimizu, Satoko Miyatake, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto, Mitsuhiro Kato, Takako Fujita, Atsushi Ishii, Shinichi Hirose, Yushi Inoue January 19, 2019

In rare cases, patients with epilepsy of infancy with migrating focal seizures (EIMFS) exhibit suppression-burst (SB) patterns on electroencephalography (EEG), similar to the findings observed for patients with Ohtahara syndrome and early myoclonic encephalopathy. In this report, we discuss six cases of EIMFS in which patients exhibited two types of SB patterns.… Read More...

Xin Tong, Dongmei An, Fenglai Xiao, Du Lei, Running Niu, Wei Li, Jiechuan Ren, Wenyu Liu, Yingying Tang, Le Zhang, Baiwan Zhou, Qiyong Gong, Dong Zhou January 18, 2019

Summary

Objective

To explore the real‐time effects of interictal epileptiform discharges (IEDs) on hippocampus and amygdala functional connectivity (FC) in unilateral temporal lobe epilepsy (TLE).

Methods

Patients with unilateral TLE were recruited and underwent simultaneous electroencephalography–functional magnetic resonance imaging (EEG‐fMRI) scanning.… Read More...

Mirja Steinbrenner, Alexander B. Kowski, Martin Holtkamp January 18, 2019

Summary

Objective

Despite the obvious advantages of resective surgery in patients with drug‐resistant focal epilepsy, namely high probability of seizure freedom, decreased mortality, and increased quality of life, referral rates from physicians and approval rates by patients for presurgical assessment remain constantly low.… Read More...

Jon T. Willie, James G. Malcolm, Matthew A. Stern, Lindsay O. Lowder, Stewart G. Neill, Brian T. Cabaniss, Daniel L. Drane, Robert E. Gross January 18, 2019

Summary

Objective

Magnetic resonance (MR) thermography–guided laser interstitial thermal therapy, or stereotactic laser ablation (SLA), is a minimally invasive alternative to open surgery for focal epilepsy caused by cerebral cavernous malformations (CCMs). We examined the safety and effectiveness of SLA of epileptogenic CCMs.… Read More...

Véronique Latreille, Barbara A. Dworetzky, Gaston Baslet, Milena Pavlova January 18, 2019

Poor sleep is a frequent complaint of patients with psychogenic non-epileptic seizures (PNES). Our group has recently reported that PNES subjects more frequently complained of poor sleep patterns relative to those with epilepsy [1], however the study was limited by use of a single item from the Beck Depression Inventory to assess changes in sleep patterns.… Read More...

Magdalena Bosak, Agnieszka Słowik, Anna Iwańska, Milena Lipińska, Wojciech Turaj January 17, 2019

Management of epilepsy usually involves the long-term use of antiepileptic drugs (AEDs) and a substantial percentage of patients require polytherapy to control their seizures [1]. The use of multiple AEDs poses a risk of drug interactions including enzyme induction or inhibition, alterations in protein-binding and expression of transporter proteins [2].… Read More...

Robert D. Nass, Lukas J. Motloch, Vera Paar, Michael Lichtenauer, Jan Baumann, Berndt Zur, Uta C. Hoppe, Stefan Holdenrieder, Christian E. Elger, Rainer Surges January 16, 2019

Summary

Objective

Generalized convulsive seizures (GCS) are associated with high demands on the cardiovascular system, thereby facilitating cardiac complications. To investigate occurrence, influencing factors, and extent of cardiac stress or injury, the alterations and time course of the latest generation of cardiac blood markers were investigated after documented GCS.… Read More...

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