Epilepsy

Gregg H. Rawlings, Iain Perdue, Laura H. Goldstein, Alan J. Carson, Jon Stone, Markus Reuber May 22, 2019

Dissociative seizures—also referred to as psychogenic non-epileptic seizures— account for about 20% of referrals to seizure clinics [1]. Traditionally, neurologists have viewed their role as limited to the diagnosis of dissociative seizures rather than the treatment of this disorder [2]. While there is currently no clear evidence base, expert opinion has favoured psychotherapeutic treatments [3], although most patients perceive their dissociative seizures as a problem which is largely “physical” [4].… Read More...

Jose A. Ferreira, Jean-Baptiste Le Pichon, Ahmed T. Abdelmoity, Deanne Dilley, Peter Dedeken, Tony Daniels, William Byrnes May 22, 2019

Focal (partial onset) seizures are often treated similarly in children over 4 years of age and in adolescent or adult patients [1,2]. As in adults, over 25% of children have inadequate seizure control on currently available antiepileptic drugs (AEDs), or have experienced significant adverse drug effects [3,4].… Read More...

Akihisa Okumura, Keiko Shimojima, Hirokazu Kurahashi, Shingo Numoto, Shino Shimada, Atsushi Ishii, Iori Ohmori, Satoru Takahashi, Tomonari Awaya, Tetsuo Kubota, Takafumi Sakakibara, Naoko Ishihara, Ayako Hattori, Hiroyuki Torisu, Jun Tohyama, Takeshi Inoue, Akiko Haibara, Takuji Nishida, Yukihiro Yuhara, Kazushi Miya, Ryuta Tanaka, Shinichi Hirose, Toshiyuki Yamamoto May 20, 2019

Watanabe et al. reported focal epilepsy of infants with favorable outcome [1,2], and proposed an epilepsy syndrome called benign partial epilepsy in infancy [3]. Benign partial epilepsy in infancy was renamed benign infantile epilepsy (BIE) or benign familial infantile epilepsy (BFIE), if familial, and it has been described in the international classification of epilepsy [4].… Read More...

Brad K. Kamitaki, Alma Yum, James Lee, Shelly Rishty, Kartik Sivaraaman, Abdolreza Esfahanizadeh, Ram Mani, Stephen Wong May 20, 2019

Monitoring seizures with long-term video-electroencephalography (EEG) in the epilepsy monitoring unit (EMU) is one of the most useful diagnostic tools in the epileptologist’s armamentarium. While clinically useful and largely safe, this procedure is not risk-free. Adverse events reported by epilepsy centers include falls, status epilepticus, postictal psychosis, fractures, infections, and the most feared complication, sudden unexpected death in epilepsy (SUDEP) [1].… Read More...

Anteneh M. Feyissa, Gregory A. Worrell, William O. Tatum, Kaisorn L Chaichana, Mark E. Jentoft, Hugo Guerrero Cazares, Nileufer Ertekin-Taner, Steven S. Rosenfeld, Karim ReFaey, Alfredo Quinones-Hinojosa May 20, 2019

Diffuse gliomas are the most common primary brain tumor in adults, affecting about 20,000 people in the US each year [1]. Epileptic seizures often develop in patients with gliomas (40%–70%) and approximately 30% are pharmaco-resistant even after glioma resection [2,3]. There is an abundance of literature supporting the association between tumor grade and histopathology and glioma-related epilepsy [3,4].… Read More...

Alessandro Iodice, Carlotta Spagnoli, Daniele Frattini, Grazia Gabriella Salerno, Susanna Rizzi, Carlo Fusco May 19, 2019

We read with great interest the paper entitled “Compound heterozygous SZT2 mutations in two siblings with early-onset epilepsy, intellectual disability and macrocephaly” by Domingues et al. [1].

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Alvaro Sanchez-Larsen, Isabel Fernandez-Perez, Alessandro Principe, Miguel Ley, Rodrigo Rocamora May 18, 2019

Worldwide, almost 1% of the population suffers from epilepsy and its annual incidence for all ages is approximately 50 – 55 cases per 100,000 inhabitants [1,2]. In Spain, its age- and sex-adjusted prevalence per 1,000 inhabitants is 14.87 [3]. Epidemiological studies mainly focus on patients with active epilepsy, defined as those who have had at least one seizure in the last 5 years [1].… Read More...

Guray Koc, Gulin Morkavuk, Efdal Akkaya, Omer Karadas, Alev Leventoglu, Bulent Unay, Zeki Gokcil May 14, 2019

Electroencephalography (EEG) is the gold standard electrophysiological test that is routinely used for presurgical evaluation and differential diagnosis and prognosis of epilepsy [1]. However, it is a dynamic test and specific EEG abnormalities, such as interictal spike waves, sharp waves, which can be combined as interictal epileptiform discharges (IEDs), may not be obtained initially because only 29%–56% of patients with epilepsy have IED during the initial recording [1,2].… Read More...

Anis Jukkarwala, Neeraj N Baheti, Amit Dhakoji, Bhagwati Salgotra, Girish Menon, Aditya Gupta, Sanjay Prakash, Chaturbhuj Rathore May 14, 2019

Epilepsy is one the commonest neurological diseases with a prevalence of 5 per 1,000 person-years.[1,2] Treatment with antiepileptic drugs remains the primary therapy for all types of epilepsies. However, approximately one third of patients with newly diagnosed epilepsy do not adequately respond to antiepileptic drugs.[3,4] In selected patients with drug resistant epilepsy, epilepsy surgery remains the most effective treatment option [5–7].… Read More...

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