Epilepsy

William O. Tatum March 23, 2019

There is currently underutilization of ambulatory techniques in evaluating patients with episodic neurological, in addition to non-neurological conditions [1]. Prior reports comparing routine EEG with ambulatory EEG (aEEG) is often more informative for optimal seizure identification [2,3]. Furthermore, outpatient aEEG monitoring has been shown to be less expensive than inpatient 24-hour video-EEG monitoring (VEM), less restrictive to patients, and allows EEG recording in one’s natural environment with exposure to daily seizure triggers [3].… Read More...

Tanvir U. Syed, W. Curt LaFrance, Tobias Loddenkemper, Selim Benbadis, Jeremy D. Slater, Rima El-Atrache, Hashem AlBunni, Muhammad T. Khan, Sana Aziz, Nasser Y. Ali, Faraaz A. Khan, Amir Alnobani, Faraaz M. Hussain, Adam U. Syed, Mohamad Z. Koubeissi March 23, 2019

Despite cost, accessibility, and convenience advantages of diagnostic ambulatory video-EEG monitoring (AVEM) over inpatient VEM, some clinicians tend to favor inpatient VEM even when inpatient level-of-care may not be medically needed, mainly because of two concerns, one practical and another technical.… Read More...

Felippe Borlot, Robyn Whitney, Ronald D. Cohn, Shelly K. Weiss March 22, 2019

MEF2C haploinsufficiency has been described in the literature over the past decade, with the majority of patients harbouring 5q14.3 microdeletions (MIM# 613443, mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations) [1]. These patients typically present with severely impaired expressive language, gross motor delay and epilepsy.2 The phenotype may resemble Rett’s syndrome in some cases, with stereotypic behaviour, particularly hand flapping, but no microcephaly or neuroregression [3].… Read More...

Bernhard J. Steinhoff, Elisabeth Hübers, Christoph Kurth, Uta Jürges March 22, 2019

The publisher regrets that there are some missing commas in some figures appearing in the abstract, the text and Table 1. This has now been corrected in the article. The errors were only made in an “ahead of print” version of the PDF and corrected prior to final publication.… Read More...

Robert Spencer, Susruta Manivannan, Feras Sharouf, Muhammad Imran Bhatti, Malik Zaben March 22, 2019

Traumatic brain injury (TBI) is a common neurosurgical presentation, with a variable clinical phenotype depending on the severity and anatomy of injury [1, 2]. A proportion of TBI patients develop uncontrollable raised intracranial pressure (ICP). In this group, an increasingly common surgical management option is decompressive craniectomy (DC), involving the removal of a bone flap to allow the brain to swell while relieving ICP [3, 4].… Read More...

Jonna Komulainen-Ebrahim, John M. Schreiber, Salla M. Kangas, Katri Pylkäs, Maria Suo-Palosaari, Elisa Rahikkala, Johanna Liinamaa, Esa-Ville Immonen, Ilmo Hassinen, Päivi Myllynen, Heikki Rantala, Reetta Hinttala, Johanna Uusimaa March 20, 2019

Next-generation sequencing (NGS) has made genetic testing of patients with epileptic encephalopathies easier – novel variants are discovered and new phenotypes described. Variants in the same gene – even the same variant – can cause different types of epilepsy and neurodevelopmental disorders.… Read More...

Ilaria Lagorio, Federico Zara, Salvatore Striano, Pasquale Striano March 20, 2019

The first description of a family showing tremulous movement associated with myoclonic jerks and generalized seizures was provided by Uyama and colleagues in 1985 [1]. In this description, no other neurological nor neuroradiological abnormalities were identified and all the patients showed a cortical reflex myoclonus as demonstrated by the electrophysiological assessment.… Read More...

Oh-Young Kwon, Sung-Pa Park March 20, 2019

Suicidality encompasses suicidal ideation and suicide attempt. Epilepsy increases the risk of suicidality in people with epilepsy (PWE) [1–4]. In the PWE, the lifetime prevalence of suicidal ideation and the risk of suicide attempt are twice [1] and three times [2], respectively, compared to the people without epilepsy.… Read More...

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