Epilepsy

Sidharth, Suvasini Sharma, Puneet Jain, Surendra Bahadur Mathur, Rajeev Kumar Malhotra, Virendra Kumar September 12, 2019

Status epilepticus (SE) is a frequent neurological emergency with short term mortality ranging from 0.9 to 3.6% in children [1–5]. The outcome of status epilepticus is determined mainly by the underlying etiology, delays in treatment and the refractoriness of the ongoing seizures to treatment [6–10].… Read More...

Tiago S. Aguiar, Joana R. Dantas, Débora B. Cabral, Cláudia Cecília S. Rego, Lenita Zajdenverg, Gil Fernando Salles, Soniza V. Alves-Leon, Melanie Rodacki, Marco Antonio Lima September 9, 2019

Type 1 diabetes mellitus (T1D) is characterized by progressive immune-mediated destruction of pancreatic beta-cells [1]. Epilepsy is a frequent disorder; however, its etiology is unknown in most cases [2]. The hypothesis that epilepsy of unknown etiology involves autoimmunity has found increased support [3].… Read More...

Laura Montier, Zulfi Haneef, Jay Gavvala, Daniel Yoshor, Robert North, Terence Verla, Paul C. Van Ness, Janice Drabek, Alica M. Goldman September 7, 2019

Abstract

Periventricular nodular heterotopia (PNH) is a common structural malformation of cortical development. Mutations in the filamin A gene are frequent in familial cases with X‐linked PNH. However, many cases with sporadic PNH remain genetically unexplained. Although medically refractory epilepsy often brings attention to the underlying PNH, patients are often not candidates for surgical resection.… Read More...

Sonia Menon, Joseph Siewe Fodjo, Sarah Weckhuysen, Dan Bhwana, Alfred K. Njamnshi, Marieke Dekker, Robert Colebunders September 7, 2019

Epilepsy is a leading neurological condition characterized by recurrent seizures and affecting more than 50 million people worldwide [1]. There is a disproportionate geographical burden of epilepsy, with 80% of cases living in low- and middle-income countries [1]. In sub–Saharan Africa (SSA), the estimated median prevalence of epilepsy is 14.2 per 1000 [2]; there is a peak prevalence in the 20–29 years age group, with both sexes being equally affected particularly for individuals under 40 years [3].… Read More...

Martha Sajatovic, Erica K. Johnson, Robert T. Fraser, Kristin A. Cassidy, Hongyan Liu, Dilip K. Pandey, Rakale C. Quarells, Peter Scal, Samantha Schmidt, Ross Shegog, Tanya M. Spruill, Mary R. Janevic, Curtis Tatsuoka, Barbara C. Jobst September 5, 2019

Abstract

Objective

To assess depressive symptom outcomes in a pooled sample of epilepsy self‐management randomized controlled trials (RCTs) from the Managing Epilepsy Well (MEW) Network integrated research database (MEW DB).

Methods

Five prospective RCTs involving 453 adults with epilepsy compared self‐management intervention (n = 232) versus treatment as usual or wait‐list control outcomes (n = 221).… Read More...

Iván Sánchez Fernández, Marta Amengual-Gual, Cristina Barcia Aguilar, Tobias Loddenkemper September 4, 2019

There are approximately 17-23/100,000 pediatric status epilepticus (SE) episodes per year and approximately 4-15/100,000 SE episodes per year in adults [1,2]. SE is a condition with a mortality of approximately 2-5% in children and 13-19% in adults, even higher when SE is refractory or super-refractory [3].… Read More...

Bardia Abbasi, Daniel M. Goldenholz September 4, 2019

Abstract

Machine learning leverages statistical and computer science principles to develop algorithms capable of improving performance through interpretation of data rather than through explicit instructions. Alongside widespread use in image recognition, language processing, and data mining, machine learning techniques have received increasing attention in medical applications, ranging from automated imaging analysis to disease forecasting.… Read More...

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