Epilepsy

Mirjam Brackhan, Pablo Bascuñana, Tobias L. Ross, Frank M. Bengel, Jens P. Bankstahl, Marion Bankstahl January 24, 2018

Summary

Objective

Accumulating evidence suggests that brain inflammation, elicited by epileptogenic insults, is involved in epilepsy development. Noninvasive nuclear imaging of brain inflammation in animal models of epileptogenesis represents a diagnostic in vivo approach with potential for direct translation into the clinic.

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Cameron S. Metcalf, Brian D. Klein, Misty D. Smith, Marc Ceusters, Hilde Lavreysen, Stefan Pype, Nancy Van Osselaer, Roy Twyman, H. Steve White January 23, 2018

Summary

Objective

We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG).

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Julien Detour, Caroline Bund, Charles Behr, Hélène Cebula, Ercument A. Cicek, Maria-Paola Valenti-Hirsch, Béatrice Lannes, Benoît Lhermitte, Astrid Nehlig, Pierre Kehrli, François Proust, Edouard Hirsch, Izzie-Jacques Namer January 17, 2018

Summary

Objective

Within a complex systems biology perspective, we wished to assess whether hippocampi with established neuropathological features have distinct metabolome. Apparently normal hippocampi with no signs of sclerosis (noHS), were compared to hippocampal sclerosis (HS) type 1 (HS1) and/or type 2 (HS2).

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Shayeeshan Sivapalarajah, Mathangi Krishnakumar, Harry Bickerstaffe, YikYing Chan, Joseph Clarkson, Alistair Hampden-Martin, Ahmad Mirza, Matthew Tanti, Anthony Marson, Munir Pirmohamed, Nasir Mirza January 17, 2018

Summary

Objective

Current antiepileptic drugs (AEDs) have several shortcomings. For example, they fail to control seizures in 30% of patients. Hence, there is a need to identify new AEDs. Drug repurposing is the discovery of new indications for approved drugs. This drug “recycling” offers the potential of significant savings in the time and cost of drug development.

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