Epilepsy

Noel Frey, Michael Bodmer, Andreas Bircher, Stephan Rüegg, Susan S. Jick, Christoph R. Meier, Julia Spoendlin October 13, 2017

Summary

Objective

Older antiepileptic drugs (AEDs) are known to cause Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). However, evidence for newer AED is sparse. We quantified risks of SJS/TEN in association with use of all AEDs in the United Kingdom.

Methods

In a matched case-control study of 480 previously validated SJS/TEN cases (1995–2013) we used conditional logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs), and calculated absolute risks of SJS/TEN within separate cohorts of new users of 28 AEDs.

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Jia Zou, Bo Zhang, David H. Gutmann, Michael Wong October 12, 2017

Summary

Objective

Epilepsy is one of the most prominent symptoms of tuberous sclerosis complex (TSC), a genetic disorder, and may be related to developmental defects resulting from impaired TSC1 or TSC2 gene function in astrocytes and neurons. Inactivation of the Tsc1 gene driven by a glial-fibrillary acidic protein (GFAP) promoter during embryonic brain development leads to widespread pathologic effects on astrocytes and neurons, culminating in severe, progressive epilepsy in mice (Tsc1GFAP-Cre mice).

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Max O. Krucoff, Alvin Y. Chan, Stephen C. Harward, Shervin Rahimpour, John D. Rolston, Carrie Muh, Dario J. Englot October 10, 2017

Summary

Objective

Medically refractory epilepsy is a debilitating disorder that is particularly challenging to treat in patients who have already failed a surgical resection. Evidence regarding outcomes of further epilepsy surgery is limited to small case series and reviews. Therefore, our group performed the first quantitative meta-analysis of the literature from the past 30 years to assess for rates and predictors of successful reoperations.

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