Epilepsy

Iva Speck, Matthias Echternach, Daniela Sammler, Andreas Schulze-Bonhage, February 1, 2018

Summary

The objective of our study was to assess alterations in speech as a possible localizing sign in frontal lobe epilepsy. Ictal speech was analyzed in 18 patients with frontal lobe epilepsy (FLE) during seizures and in the interictal period. Matched identical words were analyzed regarding alterations in fundamental frequency (ƒo) as an approximation of pitch.

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Sophie Adler, Seok-Jun Hong, Min Liu, Torsten Baldeweg, J. Helen Cross, Andrea Bernasconi, Boris C. Bernhardt, Neda Bernasconi January 31, 2018

Summary

Objective

In drug-resistant temporal lobe epilepsy (TLE), relative to the large number of whole-brain morphological studies, neocortical T2 changes have not been systematically investigated. The aim of this study was to assess the anatomical principles that govern the distribution of neocortical T2-weighted fluid-attenuated inversion recovery (FLAIR) signal intensity and uncover its topographic principles.

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Lacey Smith, Nilika Singhal, Christelle M. El Achkar, Gessica Truglio, Beth Rosen Sheidley, Joseph Sullivan, Annapurna Poduri January 29, 2018

Summary

Objective

To characterize the features associated with PCDH19-related epilepsy, also known as “female-limited epilepsy.”

Methods

We analyzed data from participants enrolled in the PCDH19 Registry, focusing on the seizure-related, developmental, neurobehavioral, and sleep-related features. We evaluated variants for pathogenicity based on previous reports, population databases, and in silico predictions, and included individuals with pathogenic or potentially pathogenic variants.

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Pragati Sharma, Kim L. Powell, Mary E. Wlodek, Terence J. O'Brien, Krista L. Gilby January 29, 2018

Summary

Objective

Aberrant myelination and developmental delay have been reported in epilepsy. However, it is unclear whether these are linked to intrinsic mechanisms that support a predisposition toward seizures and the development of epilepsy. Thus, we compared rates of myelination and neurodevelopment in male rats selectively bred for enhanced susceptibility to kindling epileptogenesis (FAST) with male rats bred for resistance (SLOW).

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Eugen Trinka, Elinor Ben-Menachem, Pedro A. Kowacs, Christian Elger, Birgit Keller, Kurt Löffler, José Francisco Rocha, Patrício Soares-da-Silva January 25, 2018

Summary

Objective

We assessed the efficacy and safety of once-daily eslicarbazepine acetate in comparison with twice-daily (BID) controlled-release carbamazepine (carbamazepine-CR) monotherapy in newly diagnosed focal epilepsy patients.

Methods

This randomized, double-blind, noninferiority trial (NCT01162460) utilized a stepwise design with 3 dose levels.

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Mirjam Brackhan, Pablo Bascuñana, Tobias L. Ross, Frank M. Bengel, Jens P. Bankstahl, Marion Bankstahl January 24, 2018

Summary

Objective

Accumulating evidence suggests that brain inflammation, elicited by epileptogenic insults, is involved in epilepsy development. Noninvasive nuclear imaging of brain inflammation in animal models of epileptogenesis represents a diagnostic in vivo approach with potential for direct translation into the clinic.

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Cameron S. Metcalf, Brian D. Klein, Misty D. Smith, Marc Ceusters, Hilde Lavreysen, Stefan Pype, Nancy Van Osselaer, Roy Twyman, H. Steve White January 23, 2018

Summary

Objective

We previously demonstrated that positive allosteric modulators (PAMs) of metabotropic glutamate subtype 2 (mGlu2) receptors have potential synergistic interactions with the antiseizure drug levetiracetam (LEV). The present study utilizes isobolographic analysis to evaluate the combined administration of JNJ-46356479, a selective and potent mGlu2 PAM, with LEV as well as sodium valproate (VPA) and lamotrigine (LTG).

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