Epilepsy

Freya Poulheim, Laura Esposito, Christian E. Elger, Anna M. Eis-Hübinger, Albert J. Becker, Pitt Niehusmann November 17, 2017

Epilepsy is one of the most common primary brain disorders. Nonparaneoplastic autoimmune encephalitis is increasingly recognized as an important cause of adult onset epilepsy. However, only in rare cases an initiating factor of the syndrome can be identified. Autoantibody detection after central nervous herpesvirus infection indicates a postviral etiology in a subgroup of patients.… Read More...

Zachary M. Grinspan, Anup D. Patel, Baria Hafeez, Erika L. Abramson, Lisa M. Kern November 16, 2017

Summary

Objective

Among children with epilepsy, to develop and evaluate a model to predict emergency department (ED) use, an indicator of poor disease control and/or poor access to care.

Methods

We used electronic health record data from 2013 to predict ED use in 2014 at 2 centers, benchmarking predictive performance against machine learning algorithms.

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David Prime, David Rowlands, Steven O'Keefe, Sasha Dionisio November 16, 2017

Summary

This review aims to highlight key considerations when performing cortico-cortical evoked potentials (CCEPs) using stereo–electroencephalography (SEEG) for network mapping and show its clinical applicability to presurgical evaluations. The parameters for performing stimulation and safety aspects have been investigated in electrocorticography (ECoG) and deep brain stimulation (DBS), but not as extensively in SEEG.

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Jayabal Velmurugan, Srikantan S. Nagarajan, Narayanan Mariyappa, Shankar G. Ravi, Kandavel Thennarasu, Ravindranadh C. Mundlamuri, Kenchaiah Raghavendra, Rose Dawn Bharath, Jitender Saini, Arimappamagan Arivazhagan, Jamuna Rajan, Anita Mahadevan, Malla B. Rao, Parthasarathy Satishchandra, Sanjib Sinha November 11, 2017

Summary

Objective

Specificity of ictal high-frequency oscillations (HFOs) in identifying epileptogenic abnormality is significant, compared to the spikes and interictal HFOs. The objectives of the study were to detect and to localize ictal HFOs by magnetoencephalography (MEG) for identifying the seizure onset zone (SOZ), evaluate the cortical excitability from preictal to ictal transition, and establish HFO concordance rates with other modalities and postsurgical resection.

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Jayabal Velmurugan, Srikantan S. Nagarajan, Narayanan Mariyappa, Shankar G. Ravi, Kandavel Thennarasu, Ravindranadh C. Mundlamuri, Kenchaiah Raghavendra, Rose Dawn Bharath, Jitender Saini, Arimappamagan Arivazhagan, Jamuna Rajan, Anita Mahadevan, Malla B. Rao, Parthasarathy Satishchandra, Sanjib Sinha November 11, 2017

Summary

Objective

Specificity of ictal high-frequency oscillations (HFOs) in identifying epileptogenic abnormality is significant, compared to the spikes and interictal HFOs. The objectives of the study were to detect and to localize ictal HFOs by magnetoencephalography (MEG) for identifying the seizure onset zone (SOZ), evaluate the cortical excitability from preictal to ictal transition, and establish HFO concordance rates with other modalities and postsurgical resection.

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Bridget N. Queenan, Raymond L. Dunn, Victor R. Santos, Yang Feng, Megan N. Huizenga, Robert J. Hammack, Stefano Vicini, Patrick A. Forcelli, Daniel T. S. Pak November 11, 2017

Summary

Objective

Homeostatic synaptic plasticity (HSP) serves as a gain control mechanism at central nervous system (CNS) synapses, including those between the dentate gyrus (DG) and CA3. Improper circuit control of DG-CA3 synapses is hypothesized to underlie epileptogenesis. Here, we sought to (1) identify compounds that preferentially modulate DG-CA3 synapses in primary neuronal culture and (2) determine if these compounds would delay or prevent epileptogenesis in vivo.

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