Epilepsy

Neil A. Youngson, Margaret J. Morris, Bill Ballard September 13, 2017

The ketogenic diet (KD) is increasingly being used to treat patients with intractable epilepsy. Despite decades of research, the reason for its success, when anticonvulsants have failed, is still not completely understood. There are, however, many candidate mechanisms which can be grouped into those that alter neuronal excitability at the synapse, and those that confer neuroprotection.… Read More...

Wesley T. Kerr, Emily A. Janio, Chelsea T. Braesch, Justine M. Le, Jessica M. Hori, Akash B. Patel, Norma L. Gallardo, Janar Bauirjan, Shannon R. D'Ambrosio, Andrea M. Chau, Eric S. Hwang, Emily C. Davis, Albert Buchard, David Torres-Barba, Mona Al Banna, Sarah E. Barritt, Andrew Y. Cho, Jerome Engel, Mark S. Cohen, John M. Stern September 12, 2017

Summary

Objective

Low-cost evidence-based tools are needed to facilitate the early identification of patients with possible psychogenic nonepileptic seizures (PNES). Prior to accurate diagnosis, patients with PNES do not receive interventions that address the cause of their seizures and therefore incur high medical costs and disability due to an uncontrolled seizure disorder.

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Peter J. Simm, Sebastian Seah, Alex Gorelik, Lauren Gilbert, Jenning Nuguid, George A. Werther, Mark T. Mackay, Jeremy L. Freeman, Sandra J. Petty, John D. Wark September 7, 2017

Summary

Objective

Antiepileptic drugs (AEDs) are associated with reduced bone density, balance impairment, and increased fracture risk in adults. However, pediatric data are limited. Therefore, we aimed to examine bone, muscle, and balance outcomes in young patients taking AEDs.

Methods

We undertook a case–control study utilizing an AED exposure–discordant matched-pair approach.

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Dora Steel, Joseph D. Symonds, Sameer M. Zuberi, Andreas Brunklaus September 7, 2017

Summary

Objective

Dravet syndrome (DS) is a severe developmental and epileptic encephalopathy characterized by the onset of prolonged febrile and afebrile seizures in infancy, and evolving to drug-resistant epilepsy with accompanying cognitive, behavioral, and motor impairment. Most cases are now known to be caused by pathogenic variants in the sodium channel gene SCN1A, but several other genes have also been implicated.

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Laura Mirandola, Roberto F. Mai, Stefano Francione, Veronica Pelliccia, Francesca Gozzo, Ivana Sartori, Lino Nobili, Francesco Cardinale, Massimo Cossu, Stefano Meletti, Laura Tassi September 7, 2017

Summary

Objective

Periventricular nodular heterotopias (PNHs) are malformations of cortical development related to neuronal migration disorders, frequently associated with drug-resistant epilepsy (DRE). Stereo-electroencephalography (SEEG) is considered a very effective step of the presurgical evaluation, providing the recognition of the epileptogenic zone (EZ).

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