Epilepsy

Benjamin D. Wissel, Hansel M. Greiner, Tracy A. Glauser, Katherine D. Holland‐Bouley, Francesco T. Mangano, Daniel Santel, Robert Faist, Nanhua Zhang, John P. Pestian, Rhonda D. Szczesniak, Judith W. Dexheimer November 30, 2019

Abstract

Objective

Delay to resective epilepsy surgery results in avoidable disease burden and increased risk of mortality. The objective was to prospectively validate a natural language processing (NLP) application that uses provider notes to assign epilepsy surgery candidacy scores.

Methods

The application was trained on notes from (1) patients with a diagnosis of epilepsy and a history of resective epilepsy surgery and (2) patients who were seizure‐free without surgery.… Read More...

Sarah Ferrand-Sorbets, Martine Fohlen, Olivier Delalande, Kevin Zuber, Christine Bulteau, Mikael Levy, Pauline Chamard, Delphine Taussig, Nathalie Dorison, Olivier Bekaert, Martin Tisdall, Mathilde Chipaux, Georg Dorfmüller November 30, 2019

Hypothalamic hamartomas (HH) are rare (1:200000) congenital heterotopic and non-neoplastic lesions [1]. They can be attached to the hypothalamus at the inferior part of the third ventricle or to its wall, to the tuber cinereum, or to the mammillary bodies. HH are composed of mixed neuronal and glial cells that usually take the form of nodules.… Read More...

Jon Stone, Hannah Callaghan, Emily J Robinson, Alan Carson, Markus Reuber, Trudie Chalder, Iain Perdue, Laura H. Goldstein November 29, 2019

Patients with functional disorders, including dissociative (non-epileptic) seizures (also called psychogenic non-epileptic seizures), are often considered ‘difficult to help’ by neurologists [1]. There is evidence that consultations in which neurologist explain this diagnosis are often challenging for doctor and patient [2,3].… Read More...

Joseph Samuel Peedicail, Sherry Sandy, Shaily Singh, Walter Hader, Terence Myles, James Scott, Samuel Wiebe, Neelan Pillay, on behalf of the Calgary Comprehensive Epilepsy Program collaborators November 29, 2019

Mesial temporal lobe epilepsy (mTLE) is major contributor to the group of drug resistant epilepsies and is one of the leading indications for epilepsy surgery, the most common pathology being hippocampal sclerosis (HS) [1]. There is a significant group of patients with mTLE that do not have any lesions on MRI, called “non-lesional” or “MRI-negative [2].… Read More...

Audrey Le, Mehdi Yeganeh, Daniela Buhas, Marie-Josée Trempe, Kenneth A. Myers November 29, 2019

Ketogenic diet (KD) is commonly used in drug-resistant epilepsy, but is contraindicated in some metabolic disorders (i.e. defects in carnitine pathways and beta-oxidation).1 SLC16A1 (OMIM 600682) encodes monocarboxylate transporter-1 (MCT1), involved in transmembrane transport of ketone bodies, lactate and pyruvate. Individuals with loss-of-function SLC16A1 variants are prone to recurrent metabolic ketoacidosis.2 Here, we present a girl with epilepsy and a likely pathogenic SLC16A1 variant who developed severe metabolic acidosis on KD; MCT1 haploinsufficiency may explain her metabolic response and her epilepsy.… Read More...

Nadine Conradi, Marion Behrens, Tabitha Kannemann, Nina Merkel, Adam Strzelczyk, Philipp S. Reif, Felix Rosenow, Anke Hermsen November 27, 2019

In the diagnosis and treatment of epilepsy, neuropsychology makes an important contribution to the comprehensive characterization of patients. Through the administration of standardized psychometric tests, cognitive and behavioral strengths and deficits of patients can be detected and quantified. Neuropsychological assessments not only provide useful information regarding the functionality of affected brain structures and networks, but can also be used to examine psychosocial difficulties of epilepsy patients as well as potential cognitive side effects of antiepileptic drugs [1–2].… Read More...

Jiajie Mo, Zhenyu Liu, Kai Sun, Yanshan Ma, Wenhan Hu, Chao Zhang, Yao Wang, Xiu Wang, Chang Liu, Baotian Zhao, Kai Zhang, Jianguo Zhang, Jie Tian November 27, 2019

Abstract

Objective

Temporal lobe epilepsy is a common form of epilepsy that might be amenable to surgery. However, magnetic resonance imaging (MRI)‐negative hippocampal sclerosis (HS) can hamper early diagnosis and surgical intervention for patients in clinical practice, resulting in disease progression.… Read More...

Markus Rauchenzauner, Schirin Deichmann, Sabine Pittschieler, Melanie Bergmann, Manuela Prieschl, Iris Unterberger, Benjamin Rösing, Christoph Seger, Christina Moser, Ludwig Wildt, Gerhard Luef November 26, 2019

In women with epilepsy (WWE), the use of oral contraceptives (OCs) in parallel with antiepileptic drugs (AEDs) might influence efficacy of both possibly leading to increased seizure frequency and/or unwanted pregnancies [1]. On the one hand, there is a mounting wall of literature that links the so-called enzyme-inducing AEDs (e.g.… Read More...

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