Epilepsy

Jibo Zhang, Jincao Chen April 8, 2019

We read with great interest the study by Shih et al [1] regarding the risk factors for seizures after cranioplasty. The article is well written and the authors have concluded that delayed cranioplasty procedures and seizures before cranioplasty were significantly associated with early post-cranioplasty seizures.… Read More...

Xueping Wang, Haijiao Wang, Da Xu, Lina Zhu, Ling Liu April 5, 2019

Valproic acid (VPA) is the most commonly administered first-generation antiepileptic drug (AED) and is also useful for a variety of other diseases, including bipolar disorder (BD) [1,2], migraine headache (MA) [3–5] and neuropathic pain [6,7]. The side effects of antiepileptic drugs are often the main factors restricting treatment and drug retention for patients with epilepsy [8,9].… Read More...

Minh-An Thuy Le, Si-Lei Fong, Kheng-Seang Lim, Suryani Gunadharma, Desin Pambudi Sejahtera, Anannit Visudtibhan, Derrick Chan, Somchit Vorachit, Samleng Chan, Ohnmar, Annabell E. Chua, Leonor Cabral-Lim, Norazieda Yassin, Viet-Thang Le, Chong-Tin Tan April 5, 2019

Approximately 70 million people currently live with epilepsy worldwide [1]. The availability and accessibility of antiepileptic drugs has been an issue for developing countries. In Asia, the treatment gap has ranged from 28% to as high as 98% [2]. For those who received antiepileptic drugs, there were about one-third of patients who still continue to have seizures [3].… Read More...

Philipp Spindler, Katja Bohlmann, Hans-Beatus Straub, Peter Vajkoczy, Ulf Christoph Schneider April 4, 2019

Vagus nerve stimulation (VNS) is well established in the treatment of epilepsy and disorders of depression. The prevalence of depression is high in patients with epilepsy, but still it remains unclear how patients with a comorbidity of epilepsy and symptoms of depression respond to VNS.… Read More...

Janna Riechmann, Laurent M. Willems, Rainer Boor, Matthias Kieslich, Susanne Knake, Cornelia Langner, Bernd A. Neubauer, Bettina Oberman, Heike Philippi, Jens P. Reese, Michael Rochel, Susanne Schubert-Bast, Jürgen Seeger, Peter Seipelt, Ulrich Stephani, Felix Rosenow, Hajo M. Hamer, Adam Strzelczyk April 2, 2019

Epilepsy is a common, chronic neurological disease with a clinical hallmark of recurrent seizures that places a major burden on patients, their caregivers, and society [1–3]. Moreover, disease-specific restrictions on self-sufficiency, mobility, career choice, family planning, and other social aspects as well as frequent epilepsy-related accidents and injuries have been shown to be associated with a reduced quality of life (QoL) and increased depression scores [4–7].… Read More...

Pim B. van der Meer, Marta Fiocco, Johan A.F. Koekkoek, Martin J.B. Taphoorn, Linda Dirven April 2, 2019

A thorough study has been carried out by Larsson et al. [1] based on nation-wide registers, which provides valuable information on the long-term retention rates of the most often prescribed antiepileptic drugs (AEDs) in post-stroke epilepsy. Computation of the retention rates was estimated by using the Kaplan-Meier (KM) methodology.… Read More...

Anna Szűcs, Beáta Rosdy, Anna Kelemen, András Horváth, Péter Halász March 28, 2019

In this paper we aim to review the ways of reflex seizure (RS) precipitation timely for several reasons. The recently accumulating data on seizure-provoking factors and mechanisms, as well as the high variability of reflex triggering modalities, need new systematization. The emerging concept of system epilepsy [1–4] is a major aspect highlighting seizure-triggering mechanisms.… Read More...

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