Epilepsy

Xiaozhen You, Ashley N. Zachery, Eleanor J. Fanto, Gina Norato, Sierra C. Germeyan, Eric J. Emery, Leigh N. Sepeta, Madison M. Berl, Chelsea L. Black, Edythe Wiggs, Kareem Zaghloul, Sara K. Inati, William D. Gaillard, William H. Theodore February 11, 2019

Summary

Objective

We aimed to predict language deficits after epilepsy surgery. In addition to evaluating surgical factors examined previously, we determined the impact of the extent of functional magnetic resonance imaging (fMRI) activation that was resected on naming ability.

Method

Thirty‐five adults (mean age 37.5 ± 10.9 years, 13 male) with temporal lobe epilepsy completed a preoperative fMRI auditory description decision task, which reliably activates frontal and temporal language networks.… Read More...

Ravindra Arya, Brian Ervin, J. Adam Wilson, Anna W. Byars, Leonid Rozhkov, Jason Buroker, Paul S. Horn, Craig Scholle, Hisako Fujiwara, Hansel M. Greiner, James L. Leach, Douglas F. Rose, Francesco T. Mangano, Tracy A. Glauser, Katherine D. Holland February 11, 2019

Summary

Objective

We studied age‐related dynamics of information sharing among cortical language regions with electrocorticographic high‐gamma modulation during picture‐naming and story‐listening tasks.

Methods

Seventeen epilepsy patients aged 4‐19 years, undergoing extraoperative monitoring with left‐hemispheric subdural electrodes, were included. Mutual information (MI), a nondirectional measure of shared information, between 16 pairs of cortical regions of interest, was computed from trial‐averaged 70–150 Hz power modulations during language tasks.… Read More...

Rachel Rolinski, Alison Austermuehle, Edythe Wiggs, Shubhi Agrawal, Leigh N. Sepeta, William D. Gaillard, Kareem A. Zaghloul, Sara K. Inati, William H. Theodore February 11, 2019

Summary

Objective

To assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.

Methods

In this prospective case series, 17 patients with drug‐resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1‐year follow‐up.… Read More...

Elizabeth Thiele, Eric Marsh, Maria Mazurkiewicz‐Beldzinska, Jonathan J. Halford, Boudewijn Gunning, Orrin Devinsky, Daniel Checketts, Claire Roberts February 11, 2019

Summary

Objective

Patients with Lennox‐Gastaut syndrome (LGS) who completed 1 of 2 randomized, double‐blind, placebo‐controlled trials of add‐on cannabidiol (CBD) (GWPCARE3, NCT02224560 or GWPCARE4, NCT02224690) were invited to enroll in an open‐label extension (OLE) study evaluating the long‐term safety and efficacy of CBD (GWPCARE5, NCT02224573).… Read More...

Laura Abraira, Laura Ludovica Gramegna, Manuel Quintana, Estevo Santamarina, Javier Salas-Puig, Silvana Sarria, Alex Rovira, Manuel Toledo February 8, 2019

The overall incidence of epilepsy is approximately 37.4 cases per 100,000 population per year and is increasing in older individuals [1,2]. New epilepsy diagnoses in the elderly population have increased by 3.5 cases per 100,000 over the last 25 years, and are now situated at 30 cases per 100,000 per year [2,3].… Read More...

Chayanin Tangwiriyasakul, Suejen Perani, Eugenio Abela, David W. Carmichael, Mark P. Richardson February 8, 2019

Summary

Recent evidence suggests that three specific brain networks show state‐dependent levels of synchronization before, during, and after episodes of generalized spike‐wave discharges (GSW) in patients with genetic generalized epilepsy (GGE). Here, we investigate whether synchronization in these networks differs between patients with GGE (n = 13), their unaffected first‐degree relatives (n = 17), and healthy controls (n = 18).… Read More...

Samy Mohamed Lemine Dadah, Marc Guenot, Alexandra Montavont, Bouchra El M’kaddem, Virginie Levrat, Alexis Arzimanoglou, Philippe Ryvlin, Karine Ostrowsky-Coste February 7, 2019

Patients with tuberous sclerosis complex (TSC) usually present with epileptic spams and/or focal seizures and can be good candidates for epilepsy surgery [1]. Typical absence seizures (TAS) are generalized with sudden onset and termination, lasting a few seconds, and electrographically defined by a unique EEG signature: diffuse, regular, 2.5-Hz spike-and-wave discharges (SWD).… Read More...

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