Epilepsy

Stephen W. Kruse, Kyle G. Dayton, Benton S. Purnell, Jared I. Rosner, Gordon F. Buchanan February 6, 2019

Summary

Objective

Sudden unexpected death in epilepsy (SUDEP) is the leading cause of death in patients with refractory epilepsy. Although the mechanisms for SUDEP are incompletely understood, seizure‐induced respiratory arrest (S‐IRA) has been strongly and consistently implicated. A body of evidence indicates that serotonin (5‐HT), a modulator of breathing, plays a critical role in SUDEP.… Read More...

Srinivasan Tupal, Carl L. Faingold February 5, 2019

Summary

Objective

Prevention of sudden unexpected death in epilepsy (SUDEP) is a critical goal for epilepsy therapy. The DBA/1 mouse model of SUDEP exhibits an elevated susceptibility to seizure‐induced death in response to electroconvulsive shock, hyperthermia, convulsant drug, and acoustic stimulation.… Read More...

Herbert Schulz, Ann‐Kathrin Ruppert, Federico Zara, Francesca Madia, Michele Iacomino, Maria S. Vari, Ganna Balagura, Carlo Minetti, Pasquale Striano, Amedeo Bianchi, Carla Marini, Renzo Guerrini, Yvonne G. Weber, Felicitas Becker, Holger Lerche, Claudia Kapser, Christoph J. Schankin, Wolfram S. Kunz, Rikke S. Møller, Karen L. Oliver, Susannah T. Bellows, Saul A. Mullen, Samuel F. Berkovic, Ingrid E. Scheffer, Hande Caglayan, Ugur Ozbek, Per Hoffmann, Sara Schramm, Despina Tsortouktzidis, Albert J. Becker, Thomas Sander February 5, 2019

Summary

Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Linkage and association studies suggest that the gene encoding the bromodomain‐containing protein 2 (BRD2) may increase risk of JME. The present methylation and association study followed up a recent report highlighting that the BRD2 promoter CpG island (CpG76) is differentially hypermethylated in lymphoblastoid cells from Caucasian patients with JME compared to patients with other GGE subtypes and unaffected relatives.… Read More...

Naghmeh Mahmoodian, Axel Boese, Michael Friebe, Javad Haddadnia February 5, 2019

Epilepsy is a common neurological disorder associated with recurrent and sudden excessive electrical discharges in a group of brain neurons that can disrupt the patient’s behavior and function temporarily [1]. Common treatments for epilepsy (medication and surgery), that often come with several side effects, are not able to control seizures in almost 25% of the patients.… Read More...

Yasuo Nakai, Ayaka Sugiura, Erik C. Brown, Masaki Sonoda, Jeong‐Won Jeong, Robert Rothermel, Aimee F. Luat, Sandeep Sood, Eishi Asano February 2, 2019

Summary

Objective

The strength of presurgical language mapping using electrocorticography (ECoG) is its outstanding signal fidelity and temporal resolution, but the weakness includes limited spatial sampling at an individual patient level. By averaging naming‐related high‐gamma activity at nonepileptic regions across a large number of patients, we provided the functional cortical atlases animating the neural dynamics supporting visual‐object and auditory‐description naming at the whole brain level.… Read More...

Sisi Li, Jiani Chen, Xin Tong, Ammar Taha Abdullah Abdulaziz, Xu Liu, Minglian Su, Chiyi Wang, Dong Zhou January 31, 2019

Epilepsy is characterized by unpredictable seizures [1]. Loss of consciousness during seizures may influence the driving ability of patients with epilepsy (PWE) and result in motor vehicle accidents (MVA) [2]. In China, PWE have been forbidden from driving motor vehicles since 1988, according to the Regulations of the People’s Republic of China on Road Traffic [3].… Read More...

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