Epilepsy

Katrine M. Andersen, Liselotte V. Petersen, Mogens Vestergaard, Carsten B. Pedersen, Jakob Christensen June 15, 2019

Abstract

Objective

To determine the mortality for persons with epilepsy and schizophrenia by absolute and relative measures.

Methods

This is a population‐based nationwide cohort study of persons born in Denmark from 1960 to 1987 who were alive and residing in Denmark on their 25th birthday.… Read More...

Longbo Zhang, Tianxiang Huang, Shannon Teaw, Angélique Bordey June 15, 2019

Abstract

Objectives

Patients with mammalian target of rapamycin (mTOR)–dependent malformations of cortical development (MCDs) associated with seizures display hyperperfusion and increased vessel density of the dysmorphic cortical tissue. Some studies have suggested that the vascular defect occurred independently of seizures. Here, we further examined whether hypervascularization occurs in animal models of global and focal MCD with and without seizures, and whether it is sensitive to the mTOR blocker, rapamycin, that is approved for epilepsy treatment in tuberous sclerosis complex.… Read More...

Loretta Giuliano, Daniela Fatuzzo, Greta Mainieri, Giulia Maira, Maurizio Elia, Edoardo Ferlazzo, Sara Gasparini, Alessandra Nicoletti, Vito Sofia, Mario Zappia June 15, 2019

Abstract

Objective

Eyelid myoclonia with absences (EMA) is a syndrome characterized by eyelid myoclonia with or without absences, eye closure‐induced generalized electroencephalographic (EEG) paroxysms and photosensitivity. Few data are available about the prognostic factors of this syndrome. The main objectives of our study were to describe the clinical and EEG features of a group of patients with EMA and to evaluate the presence of prognostic factors.… Read More...

Kristen Barbour, Dale C. Hesdorffer, Niu Tian, Elissa G. Yozawitz, Patricia E. McGoldrick, Steven Wolf, Tiffani L. McDonough, Aaron Nelson, Tobias Loddenkemper, Natasha Basma, Stephen B. Johnson, Zachary M. Grinspan June 15, 2019

Abstract

Objective

Sudden unexpected death in epilepsy (SUDEP) is an important cause of mortality in epilepsy. However, there is a gap in how often providers counsel patients about SUDEP. One potential solution is to electronically prompt clinicians to provide counseling via automated detection of risk factors in electronic medical records (EMRs).… Read More...

Hans Lüders, Naoki Akamatsu, Shahram Amina, Christoph Baumgartner, Selim Benbadis, Adriana Bermeo‐Ovalle, Andrew Bleasel, Alireza Bozorgi, Mar Carreño, Michael Devereaux, Guadalupe Fernandez‐Baca Vaca, Stefano Francione, Naiara García Losarcos, Hajo Hamer, Hans Holthausen, Shirin Jamal Omidi, Giridhar Kalamangalam, Andrés Kanner, Susanne Knake, Nuria Lacuey, Samden Lhatoo, Shih‐Hui Lim, Jayanthi Mani, Riki Matsumoto, Jonathan Miller, Soheyl Noachtar, André Palmini, Jun Park, Felix Rosenow, Asim Shahid, Stephan Schuele, Bernhard Steinhoff, Charles Ákos Szabo, Nitin Tandon, Kiyohito Terada, Walter Van Emde Boas, Peter Widdess‐Walsh, Philippe Kahane June 15, 2019

Summary

This article critiques the International League Against Epilepsy (ILAE) 2015‐2017 classifications of epilepsy, epileptic seizures, and status epilepticus. It points out the following shortcomings of the ILAE classifications: (1) they mix semiological terms with epileptogenic zone terminology; (2) simple and widely accepted terminology has been replaced by complex terminology containing less information; (3) seizure evolution cannot be described in any detail; (4) in the four‐level epilepsy classification, level two (epilepsy category) overlaps almost 100% with diagnostic level one (seizure type); and (5) the design of different classifications with distinct frameworks for newborns, adults, and patients in status epilepticus is confusing.… Read More...

Sheng‐Che Hung, Cheng‐Chia Lee, Hsin‐Hung Chen, Chien Chen, Hsiu‐Mei Wu, Ching‐Po Lin, Syu‐Jyun Peng June 15, 2019

Abstract

Objective

To investigate whether interhemispheric functional connectivity (FC) recovers in the first year after total callosotomy.

Methods

Eight epilepsy patients undergoing total callosotomy were recruited. Resting‐state functional magnetic resonance imaging was acquired before and after surgery. The precallosotomy and postcallosotomy interhemispheric and intrahemispheric FC was analyzed by using graph theory and voxel‐mirrored homotopic connectivity (VMHC).… Read More...

Andrea Bernasconi, Fernando Cendes, William H. Theodore, Ravnoor S. Gill, Matthias J. Koepp, Robert Edward Hogan, Graeme D. Jackson, Paolo Federico, Angelo Labate, Anna Elisabetta Vaudano, Ingmar Blümcke, Philippe Ryvlin, Neda Bernasconi June 15, 2019

Abstract

Structural magnetic resonance imaging (MRI) is of fundamental importance to the diagnosis and treatment of epilepsy, particularly when surgery is being considered. Despite previous recommendations and guidelines, practices for the use of MRI are variable worldwide and may not harness the full potential of recent technological advances for the benefit of people with epilepsy.… Read More...

Bshra A. Alsfouk, Aisha A. Alsfouk, Zhibin Chen, Patrick Kwan, Martin J. Brodie June 15, 2019

Abstract

Objective

To evaluate the long‐term pharmacological outcomes in teenagers with different epilepsies.

Method

This study included teenagers aged 13‐19 years at treatment initiation who were newly treated with antiepileptic drugs (AEDs) at the epilepsy unit of the Western Infirmary in Glasgow, Scotland, between 1 September 1982 and 30 September 2012.… Read More...

Mina Amiri, Birgit Frauscher, Jean Gotman June 15, 2019

Abstract

Objective

Low‐voltage fast activity (LVF) and low‐frequency high‐amplitude periodic spiking (PS) are the two most common seizure‐onset patterns in mesiotemporal lobe epilepsy, with different underlying mechanisms, pathology, and postsurgical outcome. The present work aims to investigate whether specific coupling patterns of high‐frequency oscillations (HFOs 80 Hz) and low‐frequency waves in the interictal period may distinguish these two patterns, and also seizure‐onset zone (SOZ) from non‐SOZ as a secondary aim.… Read More...

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