Epilepsy

Lindsey Shapiro, Jennifer C. Wong, Andrew Escayg November 24, 2019

Abstract

Objective

The endocannabinoid system (ECS) is comprised of cannabinoid receptors 1 and 2 (CB1R and CB2R), endogenous ligands, and regulatory enzymes, and serves to regulate several important physiological functions throughout the brain and body. Recent evidence suggests that the ECS may be a promising target for the treatment of epilepsy, including epilepsy subtypes that arise from mutations in the voltage‐gated sodium channel SCN1A.… Read More...

E. Beghi, G. Giussani, E. Bianchi, G. Randazzo, V. Sarcona, M. Elia, P. Striano, A. Verrotti, A. Ferretti, E. Rebessi, N. Specchio, P. Bonanni November 24, 2019

The Dup15q syndrome has received little attention because of its rarity, the fairly nonspecific phenotype, the clinical heterogeneity, and the wide spectrum of severity. Along with developmental delay, autism spectrum disorder (ASD) and epilepsy are predominant components of the clinical picture.… Read More...

Laura Licchetta, Tommaso Pippucci, Sara Baldassari, Raffaella Minardi, Federica Provini, Barbara Mostacci, Giuseppe Plazzi, Paolo Tinuper, Francesca Bisulli, On behalf of the Collaborative Group of Italian League Against Epilepsy (LICE) Genetic Study Group on SHE November 24, 2019

Sleep-related hypermotor epilepsy (SHE), previously Nocturnal Frontal Lobe Epilepsy (NFLE), is characterized by hypermotor seizures arising predominantly from sleep. Recognized etiologies include acquired injuries, structural anomalies and genetic causes [1]. The first gene for SHE, CHRNA4 (Cholinergic Receptor Nicotinic Alpha 4 Subunit MIM *118504), was identified in 1995 by linkage analysis in a large pedigree showing an autosomal dominant pattern of transmission (ADSHE).… Read More...

Elinor Ben‐Menachem, Hans Peter Grebe, Kiyohito Terada, Lori Jensen, Ting Li, Marc De Backer, Björn Steiniger‐Brach, Teresa Gasalla, Melissa Brock, Victor Biton November 23, 2019

Abstract

Objective

A large‐scale, double‐blind trial (SP0993; NCT01243177) demonstrated that lacosamide was noninferior to controlled‐release carbamazepine (carbamazepine‐CR) in terms of efficacy, and well tolerated as first‐line monotherapy in patients (≥16 years of age) with newly diagnosed epilepsy. We report primary safety outcomes from the double‐blind extension of the noninferiority trial (SP0994; NCT01465997) and post hoc analyses of pooled long‐term safety and efficacy data from both trials.… Read More...

Shan Wang, Z. Irene Wang, Yingying Tang, Andreas V. Alexopoulos, Cong Chen, Masaya Katagiri, Thandar Aung, Imad M. Najm, Meiping Ding, Shuang Wang, Patrick Chauvel November 23, 2019

Abstract

Objective

To evaluate the localization value and prognostic significance of subclinical seizures (SCSs) on scalp video‐electroencephalography monitoring (VEEG) in comparison to clinical seizures (CSs) in patients who had epilepsy surgery.

Methods

We included 123 consecutive patients who had SCSs and CSs during scalp‐VEEG evaluation.… Read More...

Andrey Zakharov, Kseniya Chernova, Gulshat Burkhanova, Gregory L. Holmes, Roustem Khazipov November 23, 2019

Abstract

Objective

Cortical spreading depolarization (SD) and seizures are often co‐occurring electrophysiological phenomena. However, the cross‐layer dynamics of SD during seizures and the effect of SD on epileptic activity across cortical layers remain largely unknown.

Methods

We explored the spatial‐temporal dynamics of SD and epileptic activity across layers of the rat barrel cortex using direct current silicone probe recordings during flurothyl‐induced seizures.… Read More...

Santoshi Billakota, J. Michael Andresen, Bryant C. Gay, Gregory R. Stewart, Nikolai B. Fedorov, Aaron C. Gerlach, Orrin Devinsky November 23, 2019

Abstract

Objective

To screen a library of potential therapeutic compounds for a woman with Lennox‐Gastaut syndrome due to a Y302C GABRB3 (c.905AG) mutation.

Methods

We compared the electrophysiological properties of cells with wild‐type or the pathogenic GABRB3 mutation.

Results

Among 1320 compounds, multiple candidates enhanced GABRB3 channel conductance in cell models.… Read More...

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