Epilepsy

Jacint Sala-Padro, Michael Fong, Zebunnessa Rahman, Melissa Bartley, Deepak Gill, Mark Dexter, Andrew Bleasel, Chong Wong March 27, 2019

The non-invasive localisation of insular lobe epilepsy (ILE) continues to pose a challenge. The suggestion of insular cortex involvement is often based upon recognition of the described clinical semiology[1–4]. Non-invasive neurophysiological investigation is often non-localising and at times discordant to the hypothesis of insular lobe involvement [5].… Read More...

J.B. Le Pichon, Lindsey Thompson, Megan Gustafson, Ahmed Abdelmoity March 27, 2019

The ketogenic diet has been found to be safe and effective in the treatment of drug resistant epilepsy in childhood. The age range of children undergoing this treatment has steadily been going down. There is strong evidence that it is a safe alternative in infants with drug resistant seizures.… Read More...

Sow Kuan Tee, Tien Lee Ong, Azman Aris, Stephanie Mei Ling See, Huey Yin Leong, Mohd Khairul Nizam Mohd Khalid, Viswanathan Shanthi March 26, 2019

Mutations in the EPM2A gene encoding a dual-specificity phosphatase (Laforin) cause an autosomal recessive fatal disorder called Lafora’s disease (LD) classically described as an adolescent-onset stimulus sensitive myoclonus, epilepsy and neurologic deterioration [1]. Skin biopsy reveals Lafora bodies (LB), which are pathognomonic and not seen with any other progressive myoclonus epilepsies.… Read More...

William O. Tatum March 23, 2019

There is currently underutilization of ambulatory techniques in evaluating patients with episodic neurological, in addition to non-neurological conditions [1]. Prior reports comparing routine EEG with ambulatory EEG (aEEG) is often more informative for optimal seizure identification [2,3]. Furthermore, outpatient aEEG monitoring has been shown to be less expensive than inpatient 24-hour video-EEG monitoring (VEM), less restrictive to patients, and allows EEG recording in one’s natural environment with exposure to daily seizure triggers [3].… Read More...

Tanvir U. Syed, W. Curt LaFrance, Tobias Loddenkemper, Selim Benbadis, Jeremy D. Slater, Rima El-Atrache, Hashem AlBunni, Muhammad T. Khan, Sana Aziz, Nasser Y. Ali, Faraaz A. Khan, Amir Alnobani, Faraaz M. Hussain, Adam U. Syed, Mohamad Z. Koubeissi March 23, 2019

Despite cost, accessibility, and convenience advantages of diagnostic ambulatory video-EEG monitoring (AVEM) over inpatient VEM, some clinicians tend to favor inpatient VEM even when inpatient level-of-care may not be medically needed, mainly because of two concerns, one practical and another technical.… Read More...

Felippe Borlot, Robyn Whitney, Ronald D. Cohn, Shelly K. Weiss March 22, 2019

MEF2C haploinsufficiency has been described in the literature over the past decade, with the majority of patients harbouring 5q14.3 microdeletions (MIM# 613443, mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations) [1]. These patients typically present with severely impaired expressive language, gross motor delay and epilepsy.2 The phenotype may resemble Rett’s syndrome in some cases, with stereotypic behaviour, particularly hand flapping, but no microcephaly or neuroregression [3].… Read More...

Bernhard J. Steinhoff, Elisabeth Hübers, Christoph Kurth, Uta Jürges March 22, 2019

The publisher regrets that there are some missing commas in some figures appearing in the abstract, the text and Table 1. This has now been corrected in the article. The errors were only made in an “ahead of print” version of the PDF and corrected prior to final publication.… Read More...

Robert Spencer, Susruta Manivannan, Feras Sharouf, Muhammad Imran Bhatti, Malik Zaben March 22, 2019

Traumatic brain injury (TBI) is a common neurosurgical presentation, with a variable clinical phenotype depending on the severity and anatomy of injury [1, 2]. A proportion of TBI patients develop uncontrollable raised intracranial pressure (ICP). In this group, an increasingly common surgical management option is decompressive craniectomy (DC), involving the removal of a bone flap to allow the brain to swell while relieving ICP [3, 4].… Read More...

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