Epilepsy

Puneet Jain, Pratima Gulati, Daad Alsowat, Miguel A Cortez, Carter Snead, Robyn Whitney October 10, 2018

The index case is a 3-year old boy with Dravet syndrome (de novo mutation in SCN1A gene; p.Ala889Thr [A889 T] variant) born to a non-consanguineous couple of south Indian origin. After an unremarkable early infancy, he presented with infrequent unprovoked hemi-clonic and generalized tonic-clonic seizures at 5 months of age.… Read More...

Felix Zahnert, Katja Menzler, Susanne Knake October 9, 2018

Brivaracetam (BRV) is the latest anti-epileptic drug (AED) approved for adjunctive therapy of focal onset seizures and was introduced to the German market in February 2016. Similarly to Levetiracetam (LEV), BRV acts through binding synaptic vesicle protein 2 A which plays a role in synaptic vesicle trafficking and is distributed almost ubiquitously in the central nervous system.… Read More...

Robert Colebunders, Gasim Abd-Elfarag, Jane Y. Carter, Peter Claver Olore, Kai Puok, Sonia Menon, Joseph Nelson Fodjo Siewe, Samit Bhattacharyya, Morrish Ojok, Richard Lako, Makoy Yibi Logora October 5, 2018

Previous surveys have demonstrated that areas with high onchocerciasis transmission are prone to an increased prevalence of epilepsy (1). To describe this epidemiological phenomenon, the term onchocerciasis-associated epilepsy (OAE) was proposed that includes different seizure presentations including nodding syndrome (NS) (2,3).… Read More...

Hideaki Kanemura, Fumikazu Sano, Tetsuo Ohyama, Masao Aihara October 4, 2018

Rolandic epilepsy (RE) usually presents with infrequent seizures and has excellent prognosis presenting with characteristic abnormal discharges on electroencephalogram (EEG), mainly “rolandic discharges (RDs)” [1]. The most striking finding of RD is the significant increase in frequency during drowsiness and through all sleep stages.… Read More...

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