Epilepsy

Ann Hyslop, Michael Duchowny August 8, 2019

Electrical stimulation mapping is a longstanding practice that aids in identification and delineation of eloquent cortex. Initially used to expand our understanding of the typical human cortex, it now plays a significant role in mapping cortical function in individuals with atypical structural and functional tissue organization undergoing epilepsy surgery.… Read More...

Divyani Garg, Ayush Agarwal, Deepa Dash, Swati Mahajan, Rajesh Kumar Singh, Rohit Bhatia, Manjari Tripathi August 5, 2019

Rasmussen’s encephalitis (RE) is a rare immune-mediated condition that classically presents in children with focal epilepsy or epilepsia partialis continua, progressive hemiplegia associated with cognitive deterioration and chronic unilateral cortical inflammation and hemi-atrophy [1]. Adults may have atypical manifestations including a prolonged prodromal phase, poorly defined residual period and slower progression [2].… Read More...

Divyani Garg, Ayush Agarwal, Deepa Dash, Swati Mahajan, Rajesh Kumar Singh, Rohit Bhatia, Manjari Tripathi August 5, 2019

Rasmussen’s encephalitis (RE) is a rare immune-mediated condition that classically presents in children with focal epilepsy or epilepsia partialis continua, progressive hemiplegia associated with cognitive deterioration and chronic unilateral cortical inflammation and hemi-atrophy [1]. Adults may have atypical manifestations including a prolonged prodromal phase, poorly defined residual period and slower progression [2].… Read More...

Li Ding, Sanjana Satish, Chengwen Zhou, Martin J. Gallagher August 1, 2019

Abstract

Objective

Patients with generalized epilepsy exhibit different epileptiform events including asymptomatic interictal spikes (IS), absence seizures with spike‐wave discharges (SWDs), and myoclonic seizures (MS). Our objective was to determine the spatiotemporal patterns of cortical activation in SWDs, IS, and MS in the Gabra1+/A322D juvenile myoclonic epilepsy mouse.… Read More...

Soo Yeon Kim, Se Song Jang, Jong-Il Kim, Hunmin Kim, Hee Hwang, Ji Eun Choi, Jong-Hee Chae, Ki Joong Kim, Byung Chan Lim August 1, 2019

After Doose et al. [1] described epilepsy with myoclonic-atonic seizure (MAE), exploration of genetic causes has been ongoing [2]. Recent studies have identified pathogenic variants in SLC2A1 and SLC6A1 in 4% and 5% of MAE patients, respectively [3,4]. SLC2A1 has also been identified as responsible for up to 10% of early onset absence epilepsy (EOAE) patients [5–7].… Read More...

Sophia Willikens, Stefan Wolking July 30, 2019

Adverse drug reactions (ADRs) are a well-known and often limiting problem in the pharmacological treatment of epilepsies. Cutaneous drug reactions – ranging from mild maculopapular exanthema (MPE) to severe Stevens-Johnson syndrome/ toxic epidermal necrolysis (SJS/TEN) are frequently observed in association with several antiepileptic drugs (AEDs) [1].… Read More...

Arturo Carpio, Mindy Chang, Hongbin Zhang, Matthew L. Romo, Alex Jaramillo, W. Allen Hauser, Elizabeth A. Kelvin July 30, 2019

Abstract

Objective

To develop a causal model for the occurrence of neurocysticercosis (NC)‐related seizures and test hypotheses generated from the model.

Methods

We used data from a randomized controlled trial comparing albendazole with placebo among patients newly diagnosed with NC. Based on our causal model, we explored the associations among albendazole treatment, NC cyst evolution, and seizure outcomes over 24 months of follow‐up using generalized linear mixed effect models.… Read More...

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