Epilepsy

Hussein Algahtani, Fahad Al-Hakami, Mohammed Al-Shehri, Bader Shirah, Mohammad H. Al-Qahtani, Angham Abdulrahman Abdulkareem, Muhammad Imran Naseer April 20, 2019

Progressive myoclonus epilepsy (PME) comprises a group of rare heterogeneous genetic disorders that are generally manifested as a combination of myoclonic and tonic-clonic seizures with cognitive impairment, ataxia and other cerebellar signs, and other neurologic deficits. They are often encompassed under the broader term “catastrophic epilepsies”, which are invariably associated with significant neurological morbidity and often early mortality.… Read More...

Ioannis Stavropoulos, Walter Louden, Cathy Queally, Jane Adcock, Maggie Tristram, Marcus Neale, Nicholas Moran, Lorena Flores L, Lina Nashef, Mark P Richardson, Charlie Bell, Sean Slaght, Julia Aram, Niki Rayner, Robert Powell, Alison Mead, Arjune Sen, Robert Elwes April 15, 2019

Perampanel (PER), one of the newer antiepileptic drugs has a novel antiseizure mechanism acting as a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor antagonist [1]. It was licensed as add-on medication for refractory focal-onset seizures after conduction of 3 phase III double-blinded randomized clinical trials [2–4] followed by an open label extension with a follow-up reaching 4 years [5].… Read More...

Unyime Eshiet April 15, 2019

Sociocultural attitudes continue to have a negative impact on the management of epilepsy in many African countries, including Nigeria [1]. The disorder is negatively affected by superstition, discrimination and stigma [2]. Religion as well as socio-cultural beliefs influences the nature of treatment and care received by people with epilepsy.… Read More...

ZhaoHui Luo, Alsharafi Walid A, Yuanyuan Xie, Hongyu Long, Wenbiao Xiao, Liqun Xu, Yujiao Fu, Li Feng, Bo Xiao April 15, 2019

The role of the non-coding genome in epilepsy has primarily been focused on the widespread disruption of microRNA (miRNA) expression and function [1]. However, the involvement of long non-coding RNAs (lncRNAs) in epilepsy remains unknown. LncRNAs are a heterogeneous group of non-coding transcripts (longer than 200 nt) that play roles in many biological processes [2] and comprise the largest portion of the mammalian non-coding transcriptome.… Read More...

Renata Grinfeld, Miguel Meira e Cruz April 14, 2019

Focal impaired awareness seizure (FIAS) is a clinical phenomenon with a prevalence of 0.8% that manifests as epileptic discharges commonly located in the amygdala-hippocampal complex. It can cause visual delusions and olfactory, auditory, or affective hallucinations [1]. Obstructive sleep apnea (OSA) is common in patients with epilepsy [2].… Read More...

Anetta Lasek-Bal April 10, 2019

Unverricht―Lundborg disease (ULD) is a type of autosomal recessive progressive myoclonus epilepsy (PME). The molecular basis for ULD involves mutations in the gene encoding cystatin B, a cysteine protease inhibitor. The gene is located on chromosome 21 at q22.3 [1]. This mutation leads to the multiplication of the C4GC4GCG minisatellite sequence repeats.… Read More...

Loretta Giuliano, Giovanni Mostile, Daniela Fatuzzo, Greta Mainieri, Alessandra Nicoletti, Vito Sofia, Mario Zappia April 10, 2019

Eyelid myoclonia with absences (EMA) is an epileptic syndrome characterized by a well-defined clinical and electroencephalographic (EEG) phenotype: eyelid myoclonia with or without absences, eye closure-induced EEG paroxysms and photosensitivity [1].

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Xiuxiu Leng, Fang Yuan, Jingjing Zhao, Changgeng Song, Zhihan Zhao, Yaoyao Zhang, Qiong Gao, Fang Yang, Wen Jiang April 9, 2019

Encephalitis is swelling and inflammation of the brain, which can be caused by infectious or autoimmune aetiologies. Up to 18.5% to 40.4% of patients were reported to develop status epilepticus (SE) during the acute stage of encephalitis and received anti-epileptic treatments.… Read More...

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