Epilepsy

Francesco Brigo September 3, 2017

The outstanding study by Zelano et al. recently published in this Journal provides further evidence that patients with otherwise unexplained late-onset seizures should be deemed to be at increased risk of a subsequent stroke [1]. The results of this nationwide register-based investigation are consistent with those of three previous population-based cohort studies [2], and suggest that unexplained late-onset seizures can be considered a biomarker of cerebrovascular disease and a risk factor for clinically overt stroke.… Read More...

Gregg H. Rawlings, Ian Brown, Brendan Stone, Markus Reuber September 3, 2017

Psychogenic nonepileptic seizures (PNES) are one of the most important differential diagnoses of epilepsy. PNES superficially resemble epileptic seizures, but are not associated with epileptiform activity. Instead, PNES are considered to have a psychological basis and can be best understood as a dissociative response to distressing stimuli [1,2].… Read More...

Maria Stella Vari, Monica Traverso, Tommaso Bellini, Francesca Madia, Francesca Pinto, Carlo Minetti, Pasquale Striano, Federico Zara September 3, 2017

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and may be associated with acquired central nervous system lesions or could be genetic.Various susceptibility genes and environmental factors are believed to be involved in the aetiology of TLE, which is considered to be a heterogeneous, polygenic, and complex disorder.… Read More...

Peter Yan, Tamar Melman, Sherry Yan, Munkhzul Otgonsuren, Zachary Grinspan September 3, 2017

Non-convulsive seizures (NCS) affect 8–50% [1–6] of critically ill patients and are associated with non-convulsive status epilepticus (NCSE), which has a high mortality rate of 17–51% [7–9]. Continuous EEG (cEEG) is a valuable tool in diagnosing NCS; however, it is labor and time intensive to review.… Read More...

Khalid Hamandi, Sandor Beniczky, Beate Diehl, Rosalind H. Kandler, Ronit M. Pressler, Arjune Sen, Juliet Solomon, Matthew C. Walker, Manny Bagary, with ILAE British Chapter Workshop Attendees September 3, 2017

Long term inpatient video-EEG monitoring (VEM) is an essential investigation in tertiary epilepsy centres [1,2]. VEM involves the recording of continuous and simultaneous video, EEG and ECG with a view to capturing clinical events of interest. The recording is typically carried out over 2–5 days, but can be longer according to the clinical situation.… Read More...

Ronak Ved, Naomi Cobbold, Kueni Igbagiri, Mark Willis, Paul Leach, Malik Zaben September 3, 2017

The internet is one of the most popular sources of healthcare information for patients [1]. Online resources can facilitate the process of informed consent and patient-centred shared decision-making, as they allow patients to gain understanding of their condition, and the treatments available, at their own pace.… Read More...

Ioanna Rizou, Veronique De Gucht, Antigone Papavasiliou, Stan Maes September 3, 2017

The literature suggests that interventions focusing on changing illness appraisals of young individuals as well as enhancing coping skills may be an effective treatment for pediatric psychosocial maladjustment [1–4]. This is especially true for children and adolescents with epilepsy. Epilepsy is amongst the most prevalent neurological diseases, with a substantial negative impact not only on the physical, but also on the cognitive, social, emotional, and behavioural functioning of the patient.… Read More...

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