Epilepsy

Ewa Lewczuk, Suchitra Joshi, John Williamson, Mouna Penmetsa, Sarah Shan, Jaideep Kapur December 9, 2017

Summary

Objective

To characterize the evolution of behavioral and electrographic seizures in an experimental electrical stimulation-based model of status epilepticus (SE) in C57Bl/6 mice, and to relate SE to various outcomes, including death and epileptogenesis.

Methods

SE was induced by continuous hippocampal stimulation and was evaluated by review of electroencephalographic recordings, spectral display, and behavior.

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Michael C. H. Li, Mark J. Cook December 9, 2017

Summary

Objectives

To review clinical evidence on the antiepileptic effects of deep brain stimulation (DBS) for drug-resistant epilepsy, its safety, and the factors influencing individual outcomes.

Methods

A comprehensive search of the medical literature (PubMed, Medline) was conducted to identify relevant articles investigating DBS therapy for drug-resistant epilepsy.

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Sara Lukmanji, Khara M. Sauro, Colin B. Josephson, K. Chelsea Altura, Samuel Wiebe, Nathalie Jetté December 9, 2017

Summary

Objective

Drug shortages are occurring at an increasing rate. From May to October 2016, there was a shortage of a level I critical antiepileptic drug, clobazam. We aimed to study the impact of this shortage on patients with epilepsy.

Methods

Adult patients from Calgary’s Comprehensive Epilepsy Program who were taking clobazam were approached to participate in the study.

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Shambhu Kumar, Bhargavi Ramanujam, PS Chandra, Deepa Dash, Santosh Mehta, Sharma Anubha, Renjith Appukutan, Manit Kumar Rana, Manjari Tripathi December 9, 2017

Summary

Objective

Antiepileptic drugs (AEDs) are routinely withdrawn during long-term video–electroencephalography (EEG) monitoring (LTM), to record sufficient number of seizures. The efficacy of rapid and slow AED taper has never been compared in a randomized control trial (RCT), which was the objective of this study.

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Benjamin Tolchin, Barbara A. Dworetzky, Gaston Baslet December 9, 2017

Summary

We conducted a prospective cohort study, examining long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures (PNES). Subjects diagnosed with documented PNES were scheduled for 4 psychiatric visits. Survival analysis was performed, and covariates were assessed for association with time to nonadherence using Cox proportional hazard regression analysis.

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Suganya Karunakaran, Matthew J. Rollo, Kamin Kim, Jessica A. Johnson, Giridhar P. Kalamangalam, Behnaam Aazhang, Nitin Tandon December 6, 2017

Summary

Objective

Identification of patient-specific epileptogenic networks is critical to designing successful treatment strategies. Multiple noninvasive methods have been used to characterize epileptogenic networks. However, these methods lack the spatiotemporal resolution to allow precise localization of epileptiform activity. We used intracranial recordings, at much higher spatiotemporal resolution, across a cohort of patients with mesial temporal lobe epilepsy (MTLE) to delineate features common to their epileptogenic networks.

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Pinar Gencpinar, Hamdi Yavuz, Öznur Bozkurt, Şenay Haspolat, Özgür Duman December 5, 2017

Febrile seizure (FS) is the most common convulsive disorder in children, and it is defined as a seizure accompanied with fever and without central nervous system infection, which occurs in infants and children of age 6 through 60 months [1]. In 50% of children, the first attack of FS occurs in the second year of life, and in 90% of children, before the age of 3 years [2].… Read More...

Kunal Bahrani, Mamta Bhushan Singh, Rohit Bhatia, Kameshwar Prasad, Deepti Vibha, Garima Shukla, Sreenivas Vishnubhatla, Victor Patterson December 5, 2017

We need cost-effective health care models that improve access without compromising patient safety and satisfaction. Initial clinic visits in epilepsy patients are used to make an etiological diagnosis, start and titrate antiepileptic drug (AED) treatment. Subsequent clinic visits serve to emphasize adherence, check seizure control, monitor chronic AED-related adverse effects and discuss any patient concerns.… Read More...

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