To characterize the evolution of behavioral and electrographic seizures in an experimental electrical stimulation-based model of status epilepticus (SE) in C57Bl/6 mice, and to relate SE to various outcomes, including death and epileptogenesis.
SE was induced by continuous hippocampal stimulation and was evaluated by review of electroencephalographic recordings, spectral display, and behavior.
Over the past decade there has been an increasing interest in using cannabinoids to treat a range of epilepsy syndromes following reports of some remarkable responses in individual patients. The situation is complicated by the fact that these agents do not appear to work via their attachment to endogenous cannabinoid receptors.
Drug shortages are occurring at an increasing rate. From May to October 2016, there was a shortage of a level I critical antiepileptic drug, clobazam. We aimed to study the impact of this shortage on patients with epilepsy.
Adult patients from Calgary’s Comprehensive Epilepsy Program who were taking clobazam were approached to participate in the study.
Antiepileptic drugs (AEDs) are routinely withdrawn during long-term video–electroencephalography (EEG) monitoring (LTM), to record sufficient number of seizures. The efficacy of rapid and slow AED taper has never been compared in a randomized control trial (RCT), which was the objective of this study.
We conducted a prospective cohort study, examining long-term adherence with psychiatric treatment among patients with psychogenic nonepileptic seizures (PNES). Subjects diagnosed with documented PNES were scheduled for 4 psychiatric visits. Survival analysis was performed, and covariates were assessed for association with time to nonadherence using Cox proportional hazard regression analysis.
Identification of patient-specific epileptogenic networks is critical to designing successful treatment strategies. Multiple noninvasive methods have been used to characterize epileptogenic networks. However, these methods lack the spatiotemporal resolution to allow precise localization of epileptiform activity. We used intracranial recordings, at much higher spatiotemporal resolution, across a cohort of patients with mesial temporal lobe epilepsy (MTLE) to delineate features common to their epileptogenic networks.
Febrile seizure (FS) is the most common convulsive disorder in children, and it is defined as a seizure accompanied with fever and without central nervous system infection, which occurs in infants and children of age 6 through 60 months . In 50% of children, the first attack of FS occurs in the second year of life, and in 90% of children, before the age of 3 years .… Read More...
We need cost-effective health care models that improve access without compromising patient safety and satisfaction. Initial clinic visits in epilepsy patients are used to make an etiological diagnosis, start and titrate antiepileptic drug (AED) treatment. Subsequent clinic visits serve to emphasize adherence, check seizure control, monitor chronic AED-related adverse effects and discuss any patient concerns.… Read More...