Epilepsy

Justus Marquetand, Susanne Knake, Adam Strzelczyk, Bernhard J. Steinhoff, Holger Lerche, Matthis Synofzik, Niels K Focke November 5, 2017

Periodic discharges in EEG and a history of rapidly progressive dementia are known to be associated with sporadic Creutzfeld-Jakob Disease (sCJD). Doubts regarding this rare but fatal diagnosis can arise, when episodic symptoms (seizures, psychiatric features, speech disturbances) are present and the EEG shows epileptiform discharges within this periodicity.… Read More...

Lorenzo Ferri, Francesca Bisulli, Roberto Mai, Laura Licchetta, Chiara Leta, Lino Nobili, Barbara Mostacci, Tommaso Pippucci, Paolo Tinuper November 5, 2017

Dishevelled EGL-10 and pleckstrin domain-containing protein 5 (DEPDC5) mutations are found in a wide spectrum of focal epilepsies ranging from epilepsy caused by malformation of cortical development to non-lesional epilepsy, including sleep-related hypermotor epilepsy (SHE). A surgical approach has been anecdotally reported in patients with DEPDC5 mutations, but most of these cases had a lesional etiology.… Read More...

Xu Liu, Bo Yan, Rui Wang, Chen Li, Chu Chen, Dong Zhou, Zhen Hong November 3, 2017

Summary

Objective

To evaluate the long-term seizure outcome and potential factors associated with seizure outcome in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis.

Methods

In the setting of a prospective, single-center, longitudinal cohort study, 109 patients were evaluated with ongoing follow-up.

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Aaron E. L. Warren, David F. Abbott, Graeme D. Jackson, John S. Archer November 3, 2017

Summary

Objective

To identify abnormal thalamocortical circuits in the severe epilepsy of Lennox–Gastaut syndrome (LGS) that may explain the shared electroclinical phenotype and provide potential treatment targets.

Methods

Twenty patients with a diagnosis of LGS (mean age = 28.5 years) and 26 healthy controls (mean age = 27.6 years) were compared using task-free functional magnetic resonance imaging (MRI).

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