Epilepsy

Simone Beretta, Davide Carone, Clara Zanchi, Elisa Bianchi, Marta Pirovano, Claudia Trentini, Giada Padovano, Matteo Colombo, Diletta Cereda, Sofia Scanziani, Giorgia Giussani, Sara Gasparini, Graziella Bogliun, Carlo Ferrarese, Ettore Beghi, September 3, 2017

Summary

Objective

The new epilepsy definition adopted by the International League Against Epilepsy (ILAE) includes patients with one unprovoked seizure with a probability of further seizures, similar to the general recurrence risk after two unprovoked seizures, occurring in a 10-year period.

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Tyler E. Gaston, E. Martina Bebin, Gary R. Cutter, Yuliang Liu, Jerzy P. Szaflarski, September 3, 2017

Summary

Objective

To identify potential pharmacokinetic interactions between the pharmaceutical formulation of cannabidiol (CBD; Epidiolex) and the commonly used antiepileptic drugs (AEDs) through an open-label safety study. Serum levels were monitored to identify interactions between CBD and AEDs.

Methods

In 39 adults and 42 children, CBD dose was started at 5 mg/kg/day and increased every 2 weeks by 5 mg/kg/day up to a maximum of 50 mg/kg/day.

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Luigi Maccotta, Mayra A. Lopez, Babatunde Adeyemo, Beau M. Ances, Brian K. Day, Lawrence N. Eisenman, Joshua L. Dowling, Eric C. Leuthardt, Bradley L. Schlaggar, Robert Edward Hogan September 3, 2017

Summary

Objectives

Specific changes in the functional connectivity of brain networks occur in patients with epilepsy. Yet whether such changes reflect a stable disease effect or one that is a function of active seizure burden remains unclear. Here, we longitudinally assessed the connectivity of canonical cognitive functional networks in patients with intractable temporal lobe epilepsy (TLE), both before and after patients underwent epilepsy surgery and achieved seizure freedom.

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Emily L. Johnson, Peter W. Kaplan September 3, 2017

Summary

Objective

Approximately 25 million individuals older than age 15 identify as transgender, representing about 0.3–0.9% of the world’s population. The aim of this paper is to identify and describe important medical and social considerations facing transgender persons with epilepsy.

Methods

We performed literature searches on the following terms: transgender AND epilepsy, transgender AND neurology, gender dysphoria AND epilepsy, gender dysphoria AND neurology.

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Monica Puligheddu, Miriam Melis, Giuliano Pillolla, Giulia Milioli, Liborio Parrino, Giovanni Mario Terzano, Sonia Aroni, Claudia Sagheddu, Francesco Marrosu, Marco Pistis, Anna Lisa Muntoni September 3, 2017

Summary

Objective

Nocturnal frontal lobe epilepsy (NFLE) is an idiopathic partial epilepsy with a family history in about 25% of cases, with autosomal dominant inheritance (autosomal dominant NFLE [ADNFLE]). Traditional antiepileptic drugs are effective in about 55% of patients, whereas the rest remains refractory.

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Mayara Vendramin Pasquetti, Letícia Meier, Samanta Loureiro, Marcelo Ganzella, Bernardo Junges, Letícia Barbieri Caus, Alexandre Umpierrez Amaral, David M. Koeller, Stephen Goodman, Michael Woontner, Diogo Onofre Gomes de Souza, Moacir Wajner, Maria Elisa Calcagnotto September 3, 2017

Summary

Objectives

Glutaric acidemia type I (GA-I) is an inherited neurometabolic disorder caused by deficiency of glutaryl-CoA dehydrogenase (GCDH) and characterized by increased levels of glutaric, 3-OH-glutaric, and glutaconic acids in the brain parenchyma. The increment of these organic acids inhibits glutamate decarboxylase (GAD) and consequently lowers the γ-aminobutyric acid (GABA) synthesis.

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Nina Dupuis, Julie Enderlin, Jeremy Thomas, Béatrice Desnous, Pascal Dournaud, Delphine Allorge, Stéphane Auvin September 3, 2017

Summary

Objective

Perampanel (PER) is a selective noncompetitive antagonist at α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors, the first of its class approved for the adjunctive treatment of partial onset seizures and generalized seizures. This study explored anti-ictogenic and antiepileptogenic effects of PER in rats at different stages of development.

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Oscar H. Del Brutto, Gianfranco Arroyo, Victor J. Del Brutto, Mauricio Zambrano, Héctor H. García September 3, 2017

Summary

Objective

Using a large-scale population-based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis (NCC) and its relationship with epilepsy in community-dwellers aged ≥20 years living in Atahualpa (rural Ecuador).

Methods

In a three-phase epidemiological study, individuals with suspected seizures were identified during a door-to-door survey and an interview (phase I).

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Isabelle Niespodziany, Jean-Michel Rigo, Gustave Moonen, Alain Matagne, Henrik Klitgaard, Christian Wolff September 3, 2017

Summary

Brivaracetam (BRV) is a selective, high-affinity ligand for synaptic vesicle protein 2A (SV2A), recently approved as adjunctive treatment for drug-refractory partial-onset seizures in adults. BRV binds SV2A with higher affinity than levetiracetam (LEV), and was shown to have a differential interaction with SV2A.

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