Epilepsy

Jayabal Velmurugan, Srikantan S. Nagarajan, Narayanan Mariyappa, Shankar G. Ravi, Kandavel Thennarasu, Ravindranadh C. Mundlamuri, Kenchaiah Raghavendra, Rose Dawn Bharath, Jitender Saini, Arimappamagan Arivazhagan, Jamuna Rajan, Anita Mahadevan, Malla B. Rao, Parthasarathy Satishchandra, Sanjib Sinha November 11, 2017

Summary

Objective

Specificity of ictal high-frequency oscillations (HFOs) in identifying epileptogenic abnormality is significant, compared to the spikes and interictal HFOs. The objectives of the study were to detect and to localize ictal HFOs by magnetoencephalography (MEG) for identifying the seizure onset zone (SOZ), evaluate the cortical excitability from preictal to ictal transition, and establish HFO concordance rates with other modalities and postsurgical resection.

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Jayabal Velmurugan, Srikantan S. Nagarajan, Narayanan Mariyappa, Shankar G. Ravi, Kandavel Thennarasu, Ravindranadh C. Mundlamuri, Kenchaiah Raghavendra, Rose Dawn Bharath, Jitender Saini, Arimappamagan Arivazhagan, Jamuna Rajan, Anita Mahadevan, Malla B. Rao, Parthasarathy Satishchandra, Sanjib Sinha November 11, 2017

Summary

Objective

Specificity of ictal high-frequency oscillations (HFOs) in identifying epileptogenic abnormality is significant, compared to the spikes and interictal HFOs. The objectives of the study were to detect and to localize ictal HFOs by magnetoencephalography (MEG) for identifying the seizure onset zone (SOZ), evaluate the cortical excitability from preictal to ictal transition, and establish HFO concordance rates with other modalities and postsurgical resection.

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Bridget N. Queenan, Raymond L. Dunn, Victor R. Santos, Yang Feng, Megan N. Huizenga, Robert J. Hammack, Stefano Vicini, Patrick A. Forcelli, Daniel T. S. Pak November 11, 2017

Summary

Objective

Homeostatic synaptic plasticity (HSP) serves as a gain control mechanism at central nervous system (CNS) synapses, including those between the dentate gyrus (DG) and CA3. Improper circuit control of DG-CA3 synapses is hypothesized to underlie epileptogenesis. Here, we sought to (1) identify compounds that preferentially modulate DG-CA3 synapses in primary neuronal culture and (2) determine if these compounds would delay or prevent epileptogenesis in vivo.

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Bridget N. Queenan, Raymond L. Dunn, Victor R. Santos, Yang Feng, Megan N. Huizenga, Robert J. Hammack, Stefano Vicini, Patrick A. Forcelli, Daniel T. S. Pak November 11, 2017

Summary

Objective

Homeostatic synaptic plasticity (HSP) serves as a gain control mechanism at central nervous system (CNS) synapses, including those between the dentate gyrus (DG) and CA3. Improper circuit control of DG-CA3 synapses is hypothesized to underlie epileptogenesis. Here, we sought to (1) identify compounds that preferentially modulate DG-CA3 synapses in primary neuronal culture and (2) determine if these compounds would delay or prevent epileptogenesis in vivo.

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Shanna M. Guilfoyle, Katherine Follansbee-Junger, Aimee W. Smith, Angela Combs, Shannon Ollier, Brooke Hater, Avani C. Modi November 11, 2017

Summary

Objective

To examine baseline psychological functioning and antiepileptic drug (AED) behavioral side effects in new onset epilepsy and determine, by age, whether baseline psychological functioning predicts AED behavioral side effects 1 month following AED initiation.

Methods

A retrospective chart review was conducted between July 2011 and December 2014 that included youths with new onset epilepsy.

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Jonas M. Heijer, Willem M. Otte, Eric Diessen, Jolien S. Campen, E. Lorraine Hompe, Floor E. Jansen, Marian Joels, Kees P. J. Braun, Josemir W. Sander, Maeike Zijlmans November 11, 2017

Summary

Objective

The most common reported seizure-precipitant is stress. We recently showed a biologic basis for stress sensitivity of seizures: cortisol levels in people with stress-sensitive epilepsy correlated with focal interictal epileptiform discharges (IEDs) on electroencephalography (EEG). Here we aimed to determine whether the effect of cortisol on the epileptic brain is global or focal, and whether cortisol affects all brains or just those of stress-sensitive people.

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Jerry J. Shih, Nathan B. Fountain, Susan T. Herman, Anto Bagic, Fred Lado, Susan Arnold, Mary L. Zupanc, Ellen Riker, David M. Labiner November 11, 2017

Summary

Although the epilepsy and neurology communities have position papers on a number of topics pertaining to epilepsy diagnosis and management, no current paper exists for the rationale and appropriate indications for epilepsy monitoring unit (EMU) evaluation. General neurologists, hospital administrators, and insurers also have yet to fully understand the role this type of testing has in the diagnosis and management of individuals with paroxysmal neurologic symptoms.

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Leonie Runtz, Benoit Girard, Marion Toussenot, Julie Espallergues, Alexis Fayd'Herbe De Maudave, Alexandre Milman, Frederic deBock, Chaitali Ghosh, Nathalie C. Guérineau, Jean-Marc Pascussi, Federica Bertaso, Nicola Marchi November 11, 2017

Summary

Objective

Available evidence points to a role of cytochrome P450 (Cyp) drug biotransformation enzymes in central nervous system diseases, including epilepsy. Deviations in drug pharmacokinetic profiles may impact therapeutic outcomes. Here, we ask whether spontaneous recurrent seizure (SRS) activity is sufficient to modulate the expression of major Cyp enzymes in the liver and brain.

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