Epilepsy

Iris Unterberger, Eugen Trinka, Peter W. Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer January 16, 2018

Summary

Objective

Clinical absences are now classified as “generalized nonmotor (absence) seizures” by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge.

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Iris Unterberger, Eugen Trinka, Peter W. Kaplan, Gerald Walser, Gerhard Luef, Gerhard Bauer January 16, 2018

Summary

Objective

Clinical absences are now classified as “generalized nonmotor (absence) seizures” by the International League Against Epilepsy (ILAE). The aim of this paper is to critically review the concept of absences and to put the accompanying focal and motor symptoms into the context of the emerging pathophysiological knowledge.

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Kristina A. Simeone, Jodi Hallgren, Charles S. Bockman, Ankita Aggarwal, Vikash Kansal, Lauren Netzel, Shruthi H. Iyer, Stephanie A. Matthews, Malavika Deodhar, Peter J. Oldenburg, Peter W. Abel, Timothy A. Simeone January 16, 2018

Summary

Objective

Increased breathing rate, apnea, and respiratory failure are associated with sudden unexpected death in epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kcna1−/− mice, a model of temporal lobe epilepsy and SUDEP. Here we tested the hypothesis that respiratory dysfunction progresses with age in Kcna1−/− mice, thereby increasing risk of respiratory failure and sudden death (SD).

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Kristina A. Simeone, Jodi Hallgren, Charles S. Bockman, Ankita Aggarwal, Vikash Kansal, Lauren Netzel, Shruthi H. Iyer, Stephanie A. Matthews, Malavika Deodhar, Peter J. Oldenburg, Peter W. Abel, Timothy A. Simeone January 16, 2018

Summary

Objective

Increased breathing rate, apnea, and respiratory failure are associated with sudden unexpected death in epilepsy (SUDEP). We recently demonstrated the progressive nature of epilepsy and mortality in Kcna1−/− mice, a model of temporal lobe epilepsy and SUDEP. Here we tested the hypothesis that respiratory dysfunction progresses with age in Kcna1−/− mice, thereby increasing risk of respiratory failure and sudden death (SD).

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Orrin Devinsky, Daniel Friedman, Robert B Duckrow, Nathan B Fountain, Ryder P Gwinn, James W Leiphart, Anthony M Murro, Paul C Van Ness January 16, 2018

Summary

Objective

To study the incidence and clinical features of sudden unexpected death in epilepsy (SUDEP) in patients treated with direct brain-responsive stimulation with the RNS System.

Methods

All deaths in patients treated in clinical trials (N = 256) or following U.S.

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Orrin Devinsky, Daniel Friedman, Robert B Duckrow, Nathan B Fountain, Ryder P Gwinn, James W Leiphart, Anthony M Murro, Paul C Van Ness January 16, 2018

Summary

Objective

To study the incidence and clinical features of sudden unexpected death in epilepsy (SUDEP) in patients treated with direct brain-responsive stimulation with the RNS System.

Methods

All deaths in patients treated in clinical trials (N = 256) or following U.S.

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Ying Xu, Maree L. Hackett, Nick Glozier, Armin Nikpour, Ernest Somerville, Andrew Bleasel, Carol Ireland, Craig S. Anderson January 16, 2018

Summary

Objective

To determine the frequency and predictors of return to driving within 1 year after a diagnosis of epilepsy.

Methods

SEISMIC (the Sydney Epilepsy Incidence Study to Measure Illness Consequences) was a prospective, multicenter, community-wide study of people of all ages with newly diagnosed epilepsy in Sydney, Australia.

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A. Hotterbeekx, S. Menon, J.F.N. Siewe, R. Colebunders January 16, 2018

We read with interest the review by Moog CJ et al. (vol44, p108-112) about epilepsy in the tropics [1]. The authors discuss different causes of epilepsy and stress the importance of an integral approach to the problem, including stigma reduction. However, in their review they fail to mention the problem of epilepsy in onchocerciasis endemic regions.… Read More...

Philippe Ryvlin, Elson L. So, Charles M. Gordon, Dale C. Hesdorffer, Michael R. Sperling, Orrin Devinsky, Mark T. Bunker, Bryan Olin, Daniel Friedman January 16, 2018

Summary

Objective

Limited data are available regarding the evolution over time of the rate of sudden unexpected death in epilepsy patients (SUDEP) in drug-resistant epilepsy. The objective is to analyze a database of 40 443 patients with epilepsy implanted with vagus nerve stimulation (VNS) therapy in the United States (from 1988 to 2012) and assess whether SUDEP rates decrease during the postimplantation follow-up period.

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