Epilepsy

Zhidong Cen, Yufan Guo, Yuting Lou, Biao Jiang, Jianda Wang, Jianhua Feng September 3, 2017

DEPDC5 gene (OMIM #614191) is associated with a wide phenotypic spectrum including familial focal epilepsy with variable foci, autosomal dominant nocturnal frontal lobe epilepsy, familial temporal lobe epilepsy, epileptic spasms, focal cortical dysplasia and sudden unexpected death in epilepsy [1,2]. We report a patient with unilateral pachygyria and intractable epilepsy due to a de novo DEPDC5 mutation and further expand its phenotypic spectrum.… Read More...

Ronit M. Pressler, Stefano Seri, Nick Kane, Tim Martland, Sushma Goyal, Anand Iyer, Elliott Warren, Lesley Notghi, Peter Bill, Rachel Thornton, Richard Appleton, Sarah Doyle, Sarah Rushton, Alan Worley, Stewart G. Boyd, for the CESS Clinical Neurophysiology working group September 3, 2017

Approximately 30% of children with epilepsy do not respond to antiepileptic medication and may be candidates for a surgical treatment. There is increasing evidence that children should be considered for surgery earlier rather than later, in view of the consequence of on-going seizures on brain development [1,2].… Read More...

Michelle L. Bellon, Christopher Barton, Nikki McCaffrey, Denise Parker, Claire Hutchinson September 3, 2017

Seizures are identified as an ambulatory care sensitive (ACS) condition, where, in some cases, hospitalisation can be avoided with appropriate preventative care and management of the condition [1–3]. It is acknowledged that not all hospitalisations for seizures are preventable, including first seizures, febrile convulsions, seizures occurring from other diagnoses/non-epilepsy related causes, and uncontrolled epilepsy [4], with up to 30–40% of recurring seizures resistant to current treatment options [5].… Read More...

Piergiorgio d’ Orio, Veronica Pelliccia, Francesca Gozzo, Francesco Cardinale, Laura Castana, Giorgio Lo Russo, Gabriella Bottini, Pina Scarpa, Massimo Cossu September 3, 2017

Surgery represents a useful and effective treatment option for drug resistant focal epilepsy. Its effectiveness and safety were already demonstrated in temporal lobe epilepsy [1]. Excellent results were reported in children [2] and in young adults [3]. Regarding older patients, their age was thought to be a relative contraindication to epilepsy surgery owing to the perception of increased surgical risks and reduced chances of a favorable prognosis on seizures [4–6].… Read More...

Anina du, Toit, Chrisma Pretorius September 3, 2017

Psychogenic nonepileptic seizures (PNES), resemble or mimics epileptic seizures (ES), but are in reality episodes of altered experience, sensation and movement, not as a result of abnormal electrical discharges in the brain, but rather underlying psychological stressors [1–3]. PNES is categorized as a conversion disorder, convulsion/seizure type by the Diagnostic and Statistical Manual of Mental Disorders [4].… Read More...

Xavier De Tiège, Daniel Lundqvist, Sándor Beniczky, Stefano Seri, Ritva Paetau September 3, 2017

Magnetoencephalography (MEG) is a non-invasive neurophysiological technique that provides a direct measure of neuronal activity with a millisecond time scale (for reviews, see, e.g., [1–3]). MEG records the magnetic fields mainly generated by the postsynaptic potentials of cortical pyramidal neurons (for reviews, see, e.g., [1,2,4]).… Read More...

Qi Yuan, Weidong Zhou, Liren Zhang, Fan Zhang, Fangzhou Xu, Yan Leng, Dongmei Wei, Meina Chen September 3, 2017

Epilepsy is a neurological disorder which is characterized by the recurrence of sudden abnormal reactions of brain [1]. Epileptic seizures resulting from excessive neuronal discharge are usually accompanied by disturbances in terms of movement, sensation, mood, or mental function [2,3]. There are about 37 million patients around the world suffering from this kind of chronic neurological disorder.… Read More...

Henriette K. Dumeier, Martina P. Neininger, Almuth Kaune, Pia M. Schumacher, Andreas Merkenschlager, Wieland Kiess, Matthias K. Bernhard, Thilo Bertsche, Astrid Bertsche September 3, 2017

Prolonged seizures in children can produce fatal outcomes [1–5]. The administration of rescue medication in seizures that last longer than 5min can prevent prolonged seizures. If a rescue medication is administered within the first 15min of a seizure, the chance of successful termination of the seizure stands at 97%, which falls to 57% if rescue medication is administered any later [6,7].… Read More...

J.P. Leach, P.E. Smith, J. Craig, M. Bagary, D. Cavanagh, S. Duncan, A.R.C. Kelso, A.G. Marson, D. McCorry, L. Nashef, C. Nelson-Piercy, R. Northridge, K. Sieradzan, S. Thangaratinam, M. Walker, J. Winterbottom, M. Reuber September 3, 2017

Between 2009 and 2012 there were 26 epilepsy-related deaths in the UK of women who were pregnant or in the first post-partum year. The number of pregnancy-related deaths in women with epilepsy (WWE) has been increasing. Expert assessment suggests that most epilepsy-related deaths in pregnancy were preventable and attributable to poor seizure control.… Read More...

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