Epilepsy

Shane W. Goodwin, Piotr Wilk, M. Karen Campbell, Kathy N. Speechley September 26, 2017

Summary

Objective

Our objective was to examine the relationships of factors associated with children’s emotional well-being 2 years after diagnosis, and to examine if these relationships are mediated or moderated by family factors.

Methods

Data came from a multicenter prospective cohort study of children with newly diagnosed epilepsy from across Canada (Health-Related Quality of Life in Children with Epilepsy Study; HERQULES, n = 373).

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Inkyung Song, Iren Orosz, Inna Chervoneva, Zachary J. Waldman, Itzhak Fried, Chengyuan Wu, Ashwini Sharan, Noriko Salamon, Richard Gorniak, Sandra Dewar, Anatol Bragin, Jerome Engel, Michael R. Sperling, Richard Staba, Shennan A. Weiss September 26, 2017

Summary

Objective

Differentiating pathologic and physiologic high-frequency oscillations (HFOs) is challenging. In patients with focal epilepsy, HFOs occur during the transitional periods between the up and down state of slow waves. The preferred phase angles of this form of phase-event amplitude coupling are bimodally distributed, and the ripples (80–150 Hz) that occur during the up-down transition more often occur in the seizure-onset zone (SOZ).

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Colin B. Josephson, Arturo Gonzalez-Izquierdo, Spiros Denaxas, Natalie K. Fitzpatrick, Tolulope T. Sajobi, Jordan D.T. Engbers, Scott Patten, Nathalie Jette, Samuel Wiebe September 25, 2017

Summary

Objective

Preliminary evidence suggests that serotonin reuptake inhibitor (SRI) use may increase postictal respiratory drive and prevent death. We sought to determine whether SRIs are associated with improved all-cause and possible seizure-specific mortality in patients with epilepsy.

Methods

Patients with epilepsy and a random 10:1 sample without epilepsy were extracted from The ClinicAl research using LInked Bespoke studies and Electronic health Records (CALIBER) resource.

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