Epilepsy

Xu Liu, Bo Yan, Rui Wang, Chen Li, Chu Chen, Dong Zhou, Zhen Hong November 3, 2017

Summary

Objective

To evaluate the long-term seizure outcome and potential factors associated with seizure outcome in patients with anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis.

Methods

In the setting of a prospective, single-center, longitudinal cohort study, 109 patients were evaluated with ongoing follow-up.

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Aaron E. L. Warren, David F. Abbott, Graeme D. Jackson, John S. Archer November 3, 2017

Summary

Objective

To identify abnormal thalamocortical circuits in the severe epilepsy of Lennox–Gastaut syndrome (LGS) that may explain the shared electroclinical phenotype and provide potential treatment targets.

Methods

Twenty patients with a diagnosis of LGS (mean age = 28.5 years) and 26 healthy controls (mean age = 27.6 years) were compared using task-free functional magnetic resonance imaging (MRI).

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Katherine J. Park, Gaurav Sharma, Jeffrey D. Kennedy, Masud Seyal November 3, 2017

Summary

Objective

To investigate potentially high-risk cardiac arrhythmias (PHAs) following focal to bilateral tonic–clonic seizures (FBTCSs) and generalized tonic–clonic seizures (GTCSs) and to study the association of PHAs with seizure characteristics and the severity of associated ictal respiratory dysfunction.

Methods

Electrocardiographic (EKG) and pulse oximetry (SpO2) data were recorded concurrently with video-electroencephalographic telemetry in the epilepsy monitoring unit (EMU).

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Hanna Ljung, Arto Nordlund, Maria Strandberg, Johan Bengzon, Kristina Källén November 3, 2017

Summary

Objective

To explore whether patients with refractory mesial temporal lobe epilepsy risk aggravated verbal memory loss from intracranial electroencephalography (EEG) recording with longitudinal hippocampal electrodes in the language-dominant hemisphere.

Methods

A long-term neuropsychological follow-up (mean 61.5 months, range 22–111 months) was performed in 40 patients after ictal registration with left hippocampal depth electrodes (study group, n = 16) or no invasive EEG, only extracranial registration (reference group, n = 24).

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Shane Rowley, Xiaofei Sun, Isabel V. Lima, Alexandra Tavenier, Antonio Carlos Pinheiro Oliveira, Sudhansu K. Dey, Steve C. Danzer November 3, 2017

Summary

The endocannabinoid system has gained attention as an important modulator of activity in the central nervous system. Initial studies focused on cannabinoid receptor 1 (CB1), which is widely expressed in the brain, but recent work also implicates cannabinoid receptor 2 (CB2) in modulating neuronal activity.

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Pierre Bourdillon, Caroline Apra, Marc Guénot, Hugues Duffau November 3, 2017

Summary

Objective

To analyze the conceptual and practical implications of a hodotopic approach in neurosurgery, and to compare the similarities and the differences in neuroplasticity mechanisms between low-grade gliomas and nonlesional epilepsy.

Methods

We review the recent data about the hodotopic organization of the brain connectome, alongside the organization of epileptic networks, and analyze how these two structures interact, suggesting therapeutic prospects.

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