Epilepsy

J.P. Leach, P.E. Smith, J. Craig, M. Bagary, D. Cavanagh, S. Duncan, A.R.C. Kelso, A.G. Marson, D. McCorry, L. Nashef, C. Nelson-Piercy, R. Northridge, K. Sieradzan, S. Thangaratinam, M. Walker, J. Winterbottom, M. Reuber September 3, 2017

Between 2009 and 2012 there were 26 epilepsy-related deaths in the UK of women who were pregnant or in the first post-partum year. The number of pregnancy-related deaths in women with epilepsy (WWE) has been increasing. Expert assessment suggests that most epilepsy-related deaths in pregnancy were preventable and attributable to poor seizure control.… Read More...

Francesco Brigo September 3, 2017

The outstanding study by Zelano et al. recently published in this Journal provides further evidence that patients with otherwise unexplained late-onset seizures should be deemed to be at increased risk of a subsequent stroke [1]. The results of this nationwide register-based investigation are consistent with those of three previous population-based cohort studies [2], and suggest that unexplained late-onset seizures can be considered a biomarker of cerebrovascular disease and a risk factor for clinically overt stroke.… Read More...

Gregg H. Rawlings, Ian Brown, Brendan Stone, Markus Reuber September 3, 2017

Psychogenic nonepileptic seizures (PNES) are one of the most important differential diagnoses of epilepsy. PNES superficially resemble epileptic seizures, but are not associated with epileptiform activity. Instead, PNES are considered to have a psychological basis and can be best understood as a dissociative response to distressing stimuli [1,2].… Read More...

Maria Stella Vari, Monica Traverso, Tommaso Bellini, Francesca Madia, Francesca Pinto, Carlo Minetti, Pasquale Striano, Federico Zara September 3, 2017

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy and may be associated with acquired central nervous system lesions or could be genetic.Various susceptibility genes and environmental factors are believed to be involved in the aetiology of TLE, which is considered to be a heterogeneous, polygenic, and complex disorder.… Read More...

Peter Yan, Tamar Melman, Sherry Yan, Munkhzul Otgonsuren, Zachary Grinspan September 3, 2017

Non-convulsive seizures (NCS) affect 8–50% [1–6] of critically ill patients and are associated with non-convulsive status epilepticus (NCSE), which has a high mortality rate of 17–51% [7–9]. Continuous EEG (cEEG) is a valuable tool in diagnosing NCS; however, it is labor and time intensive to review.… Read More...

Khalid Hamandi, Sandor Beniczky, Beate Diehl, Rosalind H. Kandler, Ronit M. Pressler, Arjune Sen, Juliet Solomon, Matthew C. Walker, Manny Bagary, with ILAE British Chapter Workshop Attendees September 3, 2017

Long term inpatient video-EEG monitoring (VEM) is an essential investigation in tertiary epilepsy centres [1,2]. VEM involves the recording of continuous and simultaneous video, EEG and ECG with a view to capturing clinical events of interest. The recording is typically carried out over 2–5 days, but can be longer according to the clinical situation.… Read More...

Ronak Ved, Naomi Cobbold, Kueni Igbagiri, Mark Willis, Paul Leach, Malik Zaben September 3, 2017

The internet is one of the most popular sources of healthcare information for patients [1]. Online resources can facilitate the process of informed consent and patient-centred shared decision-making, as they allow patients to gain understanding of their condition, and the treatments available, at their own pace.… Read More...

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