Anelia A. Y. Kassi, Anil K. Mahavadi, Angelica Clavijo, Daniela Caliz, Stephanie W. Lee, Aminul I. Ahmed, Shoji Yokobori, Zhen Hu, Markus S. Spurlock, Joseph M Wasserman, Karla N. Rivera, Samuel Nodal, Henry R. Powell, Long Di, Rolando Torres, Lai Yee Leung, Andres Mariano Rubiano, Ross M.… Read More...
Moreno-Bravo et al. use a conditional-knockout strategy and light sheet fluorescence microscopy to show that netrin-1 from ventricular zone progenitors and netrin-1 from the floor plate cooperate to guide spinal cord commissural axons to and across the midline.
Recent studies have queried the role of netrin1 from floor plate (FP-netrin1) in guiding commissural axons. Wu et al. show that, in spinal cord, FP-netrin1 is required and acts at long range to guide commissural axons, collaborating with Shh.
Tanimura et al. found that motor-learning deficits in a mouse model of PD were triggered by adaptations in the thalamostriatal circuitry. Cholinergic interneuron activation of nicotinic acetylcholine receptors on thalamostriatal axons was key to the adaptation.
Lee et al. examine the functional synaptic organization of callosal projections onto layer 2/3 pyramidal neurons in the primary visual cortices of mice. They find that callosal and intra-cortical inputs with similar orientation preference cluster together on short dendritic segments.