General Neurology

Juan Antonio Moreno-Bravo, Sergi Roig Puiggros, Patrick Mehlen, Alain Chédotal January 17, 2019

Moreno-Bravo et al. use a conditional-knockout strategy and light sheet fluorescence microscopy to show that netrin-1 from ventricular zone progenitors and netrin-1 from the floor plate cooperate to guide spinal cord commissural axons to and across the midline.

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Zhuhao Wu, Shirin Makihara, Patricia T. Yam, Shaun Teo, Nicolas Renier, Nursen Balekoglu, Juan Antonio Moreno-Bravo, Olav Olsen, Alain Chédotal, Frédéric Charron, Marc Tessier-Lavigne January 17, 2019

Recent studies have queried the role of netrin1 from floor plate (FP-netrin1) in guiding commissural axons. Wu et al. show that, in spinal cord, FP-netrin1 is required and acts at long range to guide commissural axons, collaborating with Shh.

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Asami Tanimura, Yijuan Du, Jyothisri Kondapalli, David L. Wokosin, D. James Surmeier January 15, 2019

Tanimura et al. found that motor-learning deficits in a mouse model of PD were triggered by adaptations in the thalamostriatal circuitry. Cholinergic interneuron activation of nicotinic acetylcholine receptors on thalamostriatal axons was key to the adaptation.

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