Cerebellar lesions can lead to a series of cognitive and emotional disorders by influencing cerebral activity via cerebro-cerebellar loops. To explore changes in cognitive function and structural brain networks in patients with posterior cerebellar infarction, we conducted the current study using diffusion-weighted MRI (32 cerebellar infarction patients, 29 controls).… Read More...

Background: Stroke is the second leading cause of death after ischemic heart disease and the third leading cause of disability-adjusted life-years lost worldwide. There is a great need for developing more effective strategies to treat stroke and its resulting impairments. Among several neuroprotective strategies tested so far, the kynurenine pathway (KP) seems to be promising, but the evidence is still sparse.… Read More...

Fingolimod acts as a functional antagonist of the sphingosine-1-phosphate receptor and is widely used for relapsing-remitting multiple sclerosis (MS). Here we report the first case of nontraumatic acute epidural hematoma in a relapsing-remitting MS patient treated with fingolimod. Fingolimod might increase the risk of hemorrhage by enhancing vasospasm and causing vascular disruption.… Read More...

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The bulk of deficits accompanying mild traumatic brain injury (mTBI) is understood in terms of cortical integration—mnemonic, attentional, and cognitive disturbances are believed to involve integrative action across brain regions. Independent of integrative disturbances, mTBI may increase cortical noise, and this has not been previously considered.… Read More...

Multiple sclerosis (MS) is a neurodegenerative disease characterized by lesions in the central nervous system. Inflammation and demyelination are the leading causes of neuronal death and brain lesions formation. The immune reactivity is believed to be essential in the neuronal damage in MS.… Read More...

Isolated mitochondrial myopathy refers to the condition that mitochondrial disorders primarily affect skeletal muscle system. Here we reported a case who presented with acute respiratory failure as the initial and predominant clinical manifestation after using anesthetic drugs. The diagnosis of mitochondrial myopathy was made by histochemical findings of ragged red fibers with modified Gomori trichrome Stain in skeletal muscle biopsy and genetic detection of an A3243G point mutation in the tRNALeu (UUR) gene of mitochondrial DNA (mtDNA) in peripheral blood specimen.… Read More...

Gamma oscillations are hypothesized to temporally coordinate sensory encoding. Shin and Moore found a distinct subtype of fast spiking interneurons (FS) in SI that are nonsensory responsive and spike regularly at gamma intervals. These “gamma regular nonsensory FS” could potentially mediate perceptually relevant oscillations, independent of the LFP and sensory drive.… Read More...

Background: Some studies have demonstrated the high impact of headache and migraine in several areas of children and adolescents’ life. In recent years, there has been an increase in scientific interest in the relationship between migraine and emotional regulation, investigating the possible consequences of emotional dysregulation on physical and mental health.… Read More...

Thrombosis is the main pathogenesis of acute ischemic stroke (AIS). The main treatments for stroke either have limited efficacy or increase the risk of bleeding. ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) is a metal protease that can effectively break down VWF (Von Willebrand Factor, VWF), the key factor in thrombus formation.… Read More...