General Neurology

Anne Weissbach, Elisa Werner, Julien F. Bally, Sinem Tunc, Sebastian Löns, Dagmar Timmann, Kirsten E. Zeuner, Vera Tadic, Norbert Brüggemann, Anthony Lang, Christine Klein, Alexander Münchau, Tobias Bäumer September 4, 2017

Abstract
Objectives: To characterize neurophysiological subcortical abnormalities in myoclonus-dystonia and their modulation by alcohol administration.
Methods: Cerebellar associative learning and basal ganglia-brainstem interaction were investigated in 17 myoclonus-dystonia patients with epsilon-sarcoglycan (SGCE) gene mutation and 21 age- and sex-matched healthy controls by means of classical eyeblink conditioning and blink reflex recovery cycle before and after alcohol intake resulting in a breath alcohol concentration of 0.08% (0.8 g/l).… Read More...

Aaron F. Struck, Gamaleldin Osman, Nishi Rampal, Siddhartha Biswal, Benjamin Legros, Lawrence J. Hirsch, M. Brandon Westover, Nicolas Gaspard September 3, 2017

Objective

Find the optimal continuous electroencephalographic (CEEG) monitoring duration for seizure detection in critically ill patients.

Methods

We analyzed prospective data from 665 consecutive CEEGs, including clinical factors and time-to-event emergence of electroencephalographic (EEG) findings over 72 hours. Clinical factors were selected using logistic regression.

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Piero Perucca, Douglas E. Crompton, Susannah T. Bellows, Anne M. McIntosh, Tomas Kalincik, Mark R. Newton, Frank J. E. Vajda, Ingrid E. Scheffer, Patrick Kwan, Terence J. O'Brien, K. Meng Tan, Samuel F. Berkovic September 3, 2017

Objective

The cause of mesial temporal lobe epilepsy (MTLE) is often unknown. We ascertained to what extent newly diagnosed nonlesional MTLE actually represents familial MTLE (FMTLE).

Methods

We identified all consecutive patients presenting to the Austin Health First Seizure Clinic with MTLE and normal magnetic resonance imaging (MRI) or MRI evidence of hippocampal sclerosis over a 10-year period.

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Ashkan Shoamanesh, Lesly A. Pearce, Carlos Bazan, Luciana Catanese, Leslie A. McClure, Mukul Sharma, Joan Marti-Fabregas, David C. Anderson, Carlos S. Kase, Robert G. Hart, Oscar R. Benavente, September 3, 2017

Objective

To characterize cerebral microbleeds (CMBs) in lacunar stroke patients in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial and to assess their relationship with recurrent stroke and death, and response to assigned treatment.

Methods

SPS3 is a randomized, clinical trial conducted between 2003 and 2011.

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