General Neurology

Squair, J. W., Belanger, L. M., Tsang, A., Ritchie, L., Mac-Thiong, J.-M., Parent, S., Christie, S., Bailey, C., Dhall, S., Street, J., Ailon, T., Paquette, S., Dea, N., Fisher, C. G., Dvorak, M. F., West, C. R., Kwon, B. K. September 16, 2017

Objective:

To determine whether spinal cord perfusion pressure (SCPP) as measured with a lumbar intrathecal catheter is a more predictive measure of neurologic outcome than the conventionally measured mean arterial pressure (MAP).

Methods:

A total of 92 individuals with acute spinal cord injury were enrolled in this multicenter prospective observational clinical trial.… Read More...

Weber-Krüger, M., Lutz, C., Zapf, A., Stahrenberg, R., Seegers, J., Witzenhausen, J., Wasser, K., Hasenfuss, G., Gröschel, K., Wachter, R. September 14, 2017

Objective:

Prolonged ECG monitoring after stroke frequently reveals short paroxysmal atrial fibrillation (pAF) and supraventricular (SV) runs. The minimal duration of atrial fibrillation (AF) required to induce cardioembolism, the relevance of SV runs, and whether short pAF results from cerebral damage itself are currently being debated.… Read More...

Rubin, L. H., Maki, P. M., Springer, G., Benning, L., Anastos, K., Gustafson, D., Villacres, M. C., Jiang, X., Adimora, A. A., Waldrop-Valverde, D., Vance, D. E., Bolivar, H., Alden, C., Martin, E. M., Valcour, V. G., For the Women's Interagency HIV Study September 14, 2017

Objective:

To determine whether persistent viral suppression alters cognitive trajectories among HIV-infected (HIV+) women on combination antiretroviral therapy (cART) by investigating performance longitudinally in uninfected (HIV–) and 3 groups of HIV+ women: those with consistent viral suppression after continuous cART use (VS), those without consistent virologic suppression despite continuous cART use (NVS), and those without consistent virologic suppression after intermittent cART use (Int NVS).… Read More...

Munger, K. L., Hongell, K., Aivo, J., Soilu-Hänninen, M., Surcel, H.-M., Ascherio, A. September 14, 2017

Objective:

To determine whether and to what extent vitamin D deficiency is associated with multiple sclerosis (MS) risk.

Methods:

We conducted a prospective nested case-control study among women in the Finnish Maternity Cohort (FMC). The FMC had 1.8 million stored serum samples taken during the pregnancies of over 800,000 women at the time of this study.… Read More...

Rudd, A., Bray, B. September 14, 2017

Compelling evidence indicates that the organization and delivery of stroke care makes a difference in the chances of patients surviving, their level of disability, and the chances of further strokes. Most evidence-based interventions do not require expensive high-technology medicine but rather need well-organized basic care delivered by people with expertise in stroke.… Read More...

Latorre, J. G. S., Flanagan, S., Phipps, M. S., Shenoy, A. M., Bennett, A., Seidenwurm, D. September 14, 2017

Stroke is the fifth leading cause of death in the United States and the second leading cause of disability worldwide.1,2 “On average, every 40 seconds, someone in the United States has a stroke, and someone dies of one approximately every 4 minutes.”3 Each year, nearly 800,000 people experience stroke, with up to 185,000 experiencing recurrent stroke events.… Read More...

Alberto J. Espay, Gustavo A. Da Prat, Alok K. Dwivedi, Federico Rodriguez-Porcel, Jennifer E. Vaughan, Michela Rosso, Johnna L. Devoto, Andrew P. Duker, Mario Masellis, Charles D. Smith, J. George T. Mandybur, Aristide Merola, Anthony E. Lang September 11, 2017

ABSTRACT

Idiopathic normal pressure hydrocephalus (NPH) remains both over-suspected on clinical grounds and under-confirmed when based on immediate and sustained response to cerebrospinal fluid diversion. Poor long-term post-shunt benefits and findings of neurodegenerative pathology in most patients with adequate follow up suggests that hydrocephalic disorders appearing in late adulthood may often result from initially unapparent parenchymal abnormalities.

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