General Neurology

Pamela F. Marcott, Sheng Gong, Prashant Donthamsetti, Steven G. Grinnell, Melissa N. Nelson, Amy H. Newman, Lutz Birnbaumer, Kirill A. Martemyanov, Jonathan A. Javitch, Christopher P. Ford April 12, 2018

Marcott et al. identify that D2 receptors on MSNs differ in their sensitivity and rate of activation between the dorsal striatum and nucleus accumbens. These regional differences in signaling shape how D2 receptors encode dopamine release events in nigrostriatal and mesolimbic circuits.… Read More...

Clara Kwon Starkweather, Samuel J. Gershman, Naoshige Uchida April 12, 2018

Dopamine neurons signal reward prediction errors, driving reinforcement learning. In ambiguous settings, dopamine signals incorporate hidden state inference. We demonstrate that the medial prefrontal cortex is required for hidden state inference to influence dopamine signals, illuminating the neural circuit governing reinforcement learning under state uncertainty.… Read More...

Michael C. Regan, Timothy Grant, Miranda J. McDaniel, Erkan Karakas, Jing Zhang, Stephen F. Traynelis, Nikolaus Grigorieff, Hiro Furukawa April 12, 2018

Alternative gene splicing has a profound effect on NMDA receptor function. Through cryo-EM and electrophysiology, Regan et al. discovered that the position of an alternatively spliced motif alters receptor function by stabilizing intersubunit and interdomain interfaces within the protein.

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Georgi Tushev, Caspar Glock, Maximilian Heumüller, Anne Biever, Marko Jovanovic, Erin M. Schuman April 12, 2018

Tushev, Glock, et al. use 3′ end sequencing together with hippocampal slice microdissection to separately examine transcripts arising from somata or the neuropil. They discover a huge diversity in neuronal mRNA 3′ UTRs, which give rise to differences in localization, stability, translation, and plasticity.… Read More...

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