General Neurology

Friedman, S. D., Poliakov, A. V., Budech, C., Shaw, D. W. W., Breiger, D., Jinguji, T., Krabak, B., Coppel, D., Lewis, T. M., Browd, S., Ojemann, J. G. October 14, 2017

Objective:

To evaluate whether frontal-lobe magnetic resonance spectroscopy measures of -aminobutyric acid (GABA) would be altered in a sample of adolescents scanned after sport concussion because mild traumatic brain injury is often associated with working memory problems.

Methods:

Eleven adolescents (age 14–17 years) who had sustained a first-time sport concussion were studied with MRI/magnetic resonance spectroscopy within 23 to 44 days after injury (mean 30.4 ± 6.1 days).… Read More...

Roberts, R. O., Knopman, D. S., Syrjanen, J. A., Aakre, J. A., Vassilaki, M., Kremers, W. K., Mielke, M. M., Machulda, M. M., Graff-Radford, J., Geda, Y. E., Vemuri, P., Lowe, V., Jack, C. R., Petersen, R. C. October 14, 2017

Objective:

To estimate the prevalence of elevated brain amyloid and reduced cortical thickness (as a marker for neurodegeneration) in a defined population.

Methods:

Mayo Clinic Study of Aging participants underwent MRI to assess a composite Alzheimer disease (AD) signature cortical thickness measure and PET to assess brain amyloid accumulation.… Read More...

Mollenhauer, B., Caspell-Garcia, C. J., Coffey, C. S., Taylor, P., Shaw, L. M., Trojanowski, J. Q., Singleton, A., Frasier, M., Marek, K., Galasko, D., For the Parkinson's Progression Marker Initiative October 14, 2017

Objective:

To analyze longitudinal levels of CSF biomarkers in drug-naive patients with Parkinson disease (PD) and healthy controls (HC), examine the extent to which these biomarker changes relate to clinical measures of PD, and identify what may influence them.

Methods:

CSF α-synuclein (α-syn), total and phosphorylated tau (t- and p-tau), and β-amyloid 1–42 (Aβ42) were measured at baseline and 6 and 12 months in 173 patients with PD and 112 matched HC in the international multicenter Parkinson’s Progression Marker Initiative.… Read More...

Tsao, J. W., Stentz, L. A., Rouhanian, M., Howard, R. S., Perry, B. N., Haran, F. J., Pasquina, P. F., Wolde, M., Taylor, C. E., Lizardo, R., Liu, S., Flores, E., Creason, A. H., Sher, K. October 14, 2017

Objective:

To examine whether blast exposure alone and blast-associated concussion result in similar neurologic and mental health symptoms.

Methods:

A 14-item questionnaire was administered to male US Marines on their return from deployment in Iraq and/or Afghanistan.

Results:

A total of 2,612 Marines (median age 22 years) completed the survey.… Read More...

Mul, K., Vincenten, S. C. C., Voermans, N. C., Lemmers, R. J. L. F., van der Vliet, P. J., van der Maarel, S. M., Padberg, G. W., Horlings, C. G. C., van Engelen, B. G. M. October 14, 2017

Objective:

To add quantitative muscle MRI to the clinical trial toolbox for facioscapulohumeral muscular dystrophy (FSHD) by correlating it to clinical outcome measures in a large cohort of genetically and clinically well-characterized patients with FSHD comprising the entire clinical spectrum.

Methods:

Quantitative MRI scans of leg muscles of 140 patients with FSHD1 and FSHD2 were assessed for fatty infiltration and TIRM hyperintensities and were correlated to multiple clinical outcome measures.… Read More...

Huang, X., Li, Y., Li, P., Li, J., Bao, H., Zhang, Y., Wang, B., Sun, N., Wang, J., He, M., Yin, D., Tang, G., Chen, Y., Cui, Y., Huang, Y., Hou, F. F., Qin, X., Huo, Y., Cheng, X. October 14, 2017

Objective:

To examine whether a change in serum total homocysteine (tHcy) levels is associated with first stroke risk in a post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT).

Methods:

We analyzed 16,867 participants of the CSPPT with tHcy measurements at both baseline and exit visits.… Read More...

Akram, H., Miller, S., Lagrata, S., Hariz, M., Ashburner, J., Behrens, T., Matharu, M., Zrinzo, L. October 14, 2017

Objective:

To investigate the mechanism of action of deep brain stimulation for refractory chronic cluster headache and the optimal target within the ventral tegmental area.

Methods:

Seven patients with refractory chronic cluster headache underwent high spatial and angular resolution diffusion MRI preoperatively.… Read More...

Gelfand, J. M., Bradshaw, M. J., Stern, B. J., Clifford, D. B., Wang, Y., Cho, T. A., Koth, L. L., Hauser, S. L., Dierkhising, J., Vu, N., Sriram, S., Moses, H., Bagnato, F., Kaufmann, J. A., Ammah, D. J., Yohannes, T. H., Hamblin, M. J., Venna, N., Green, A. J., Pawate, S. October 14, 2017

Objective:

To describe clinical and imaging responses in neurosarcoidosis to infliximab, a monoclonal antibody against tumor necrosis factor–α.

Methods:

Investigators at 6 US centers retrospectively identified patients with CNS sarcoidosis treated with infliximab, including only patients with definite or probable neurosarcoidosis following rigorous exclusion of other causes.… Read More...

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