General Neurology

Narayana, S., Mudigoudar, B., Babajani-Feremi, A., Choudhri, A. F., Boop, F. A. October 12, 2017

Accurate assessment of motor function is critical, particularly in the context of presurgical functional mapping. There are a few noninvasive tools available for preoperative motor mapping in older children and adults undergoing surgery for brain tumor or refractory epilepsy including fMRI, magnetoencephalography (MEG), and transcranial magnetic stimulation (TMS).… Read More...

Prabhakaran, S. October 12, 2017

Based on prior epidemiologic studies in the United States, approximately 80% of first-time strokes can be explained by modifiable risk factors such as hypertension, and therefore optimal control or elimination of known risk factors might prevent these strokes.1 Campaigns such as the American Heart Association (AHA) initiative, Life’s Simple 7, have set ambitious goals for optimal cardiovascular and stroke risk factor control; in addition, a wealth of online resources are available for an increasingly health-conscious society.… Read More...

Cho, S.-M., Deshpande, A., Pasupuleti, V., Hernandez, A. V., Uchino, K. October 12, 2017


In a systematic review, we compared ratio of new periprocedural radiographic brain ischemia (RBI) to the number of strokes and TIAs among patients undergoing carotid endarterectomy (CEA) and carotid artery stenting (CAS).


We searched 5 databases for entries related to brain ischemia in CEA or CAS from inception through September 2015.… Read More...

Palm-Meinders, I. H., Arkink, E. B., Koppen, H., Amlal, S., Terwindt, G. M., Launer, L. J., van Buchem, M. A., Ferrari, M. D., Kruit, M. C. October 12, 2017


To assess volumetric brain changes in migraineurs from the general population compared with controls.


Structural brain changes in migraineurs from the general population-based MRI Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis (CAMERA)-2 observational cohort study were assessed by state-of-the-art voxel-based morphometry.… Read More...

Tarnopolsky, M. A., Brady, L., Tetreault, M., For the Care4Rare Canada Consortium October 12, 2017

Mitochondrial DNA (mtDNA) encodes for 22 tRNAs (mt-tRNA) that undergo posttranscriptional modification.1,2 A specific nucleotide adjacent to the anticodon of mt-tRNA (position 37) is methylated (m1G37) to enhance translational efficiency/fidelity.3 The gene tRNA methyltransferase 5 (TRMT5) encodes a protein involved in m1G37 formation for some mitochondrial tRNAs3,4 and has been associated with combined oxidative phosphorylation deficiency 26 (COXPD26) (OMIM 616539).… Read More...

Yu, A. Y. X., Rogers, E., Wang, M., Sajobi, T. T., Coutts, S. B., Menon, B. K., Hill, M. D., Smith, E. E. October 12, 2017


To describe home-time, stratified by stroke type, in a complete population and to determine its correlation with modified Rankin Scale (mRS) scores.


We used linked administrative data to derive home-time in all patients admitted for a cerebrovascular event in Alberta, Canada, between 2012 and 2016.… Read More...

Cristina Scarpazza, Luca Prosperini, Nicola De Rossi, Lucia Moiola, Maria Pia Sormani, Simonetta Gerevini, Ruggero Capra, October 11, 2017


Objective: To retrospectively analyze the effect of plasma exchange (PLEX, yes=PLEX+, no=PLEX-) and steroids administration timing (prophylactically –proST- or therapeutically –therST-) on the longitudinal clinical course of patients with natalizumab related progressive multifocal leukoencephalopathy (PML) and full blown immune reconstitution inflammatory syndrome (PML-IRIS).

Johann M.E. Jende, Gesa H. Hauck, Ricarda Diem, Markus Weiler, Sabine Heiland, Brigitte Wildemann, Mirjam Korporal-Kuhnke, Wolfgang Wick, John M. Hayes, Johannes Pfaff, Mirko Pham, Martin Bendszus, Jennifer Kollmer October 11, 2017


Objective:To detect and quantify peripheral nerve lesions in multiple sclerosis (MS) by magnetic resonance neurography (MRN).

Methods: 36 patients diagnosed with MS based on the 2010 McDonald criteria (34 with the relapsing-remitting form, 2 with clinically isolated syndrome) with and without disease modifying treatment were compared to 35 healthy age/sex-matched volunteers.

Suzan J.G. Knottnerus, Stephanie C.M. Nijmeijer, Lodewijk IJlst, Heleen te Brinke, Naomi van Vlies, Frits A Wijburg October 10, 2017


Objective: Mucopolysaccharidosis IIIA or Sanfilippo disease type A is a progressive neurodegenerative disorder presenting in early childhood, caused by an inherited deficiency of the lysosomal hydrolase sulfamidase. New missense mutations, for which genotype-phenotype correlations are currently unknown, are frequently reported, hampering early prediction of phenotypic severity and efficacy assessment of new disease-modifying treatments.


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