General Neurology

Suzan J.G. Knottnerus, Stephanie C.M. Nijmeijer, Lodewijk IJlst, Heleen te Brinke, Naomi van Vlies, Frits A Wijburg October 10, 2017

Abstract

Objective: Mucopolysaccharidosis IIIA or Sanfilippo disease type A is a progressive neurodegenerative disorder presenting in early childhood, caused by an inherited deficiency of the lysosomal hydrolase sulfamidase. New missense mutations, for which genotype-phenotype correlations are currently unknown, are frequently reported, hampering early prediction of phenotypic severity and efficacy assessment of new disease-modifying treatments.

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Prashanthi Vemuri, Timothy G. Lesnick, Scott A. Przybelski, David S. Knopman, Val J. Lowe, Jonathan Graff-Radford, Rosebud O. Roberts, Michelle M. Mielke, Mary M. Machulda, Ronald C. Petersen, Clifford R. Jack October 10, 2017

ABSTRACT

OBJECTIVE: To investigate the associations between age, vascular health, and Alzheimer’s disease (AD) imaging biomarkers in an elderly sample.

METHODS: We identified 430 individuals along the cognitive continuum aged60 years with amyloid-PET, Tau-PET, and MRI scans from the population-based Mayo Clinic Study of Aging.

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Alejandra Camacho-Soto, Mark N. Warden, Susan Searles Nielsen, Amber Salter, David L. Brody, Heidi Prather, Brad A. Racette October 10, 2017

ABSTRACT

Objective: Studies suggest a greater risk of Parkinson disease (PD) after traumatic brain injury (TBI), but it is possible that the risk of TBI is greater in the prodromal period of PD. We aimed to examine the time-to-TBI in PD patients in their prodromal period compared to population-based controls.

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Michael Bieber, Rudolf A. Werner, Edit Tanai, Ulrich Hofmann, Takahiro Higuchi, Kai Schuh, Peter U. Heuschmann, Stefan Frantz, Oliver Ritter, Peter Kraft, Christoph Kleinschnitz October 10, 2017

Abstract

Objective: Cardiac diseases are established risk factors for ischemic stroke incidence and severity. Conversely, there is increasing evidence that brain ischemia can cause cardiac dysfunction. The mechanisms underlying this neurogenic heart disease are incompletely understood. While it is established that ischemic stroke is associated with cardiac arrhythmias, myocardial damage, elevated cardiac enzymes and plasma catecholamines in the acute phase, nothing is known about the delayed consequences of ischemic stroke on cardiovascular function.

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Shila Azodi, Govind Nair, Yoshimi Enose-Akahata, Emily Charlip, Ashley Vellucci, Irene Cortese, Jennifer Dwyer, B. Jeanne Billioux, Chevaz Thomas, Joan Ohayon, Daniel S Reich, Steven Jacobson October 10, 2017

Abstract

Objective: Previous work measures spinal cord thinning in chronic progressive myelopathies, including HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and multiple sclerosis (MS). Quantitative measurements of spinal cord atrophy are important in fully characterizing these and other spinal cord diseases. We aimed to investigate patterns of spinal cord atrophy and correlations with clinical markers.

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de Koning, M. E., Scheenen, M. E., van der Horn, H. J., Timmerman, M. E., Hageman, G., Roks, G., Spikman, J. M., van der Naalt, J. October 7, 2017

Objective:

To study return to work (RTW) after mild traumatic brain injury (mTBI) at several intervals after injury and to predict RTW on the basis of occupational factors in addition to demographic, personality, and injury-related factors at 6 and 12 months after injury.… Read More...

Pozeg, P., Palluel, E., Ronchi, R., Solca, M., Al-Khodairy, A.-W., Jordan, X., Kassouha, A., Blanke, O. October 7, 2017

Objective:

To investigate changes in body ownership and chronic neuropathic pain in patients with spinal cord injury (SCI) using multisensory own body illusions and virtual reality (VR).

Methods:

Twenty patients with SCI with paraplegia and 20 healthy control participants (HC) participated in 2 factorial, randomized, repeated-measures design studies.… Read More...

Zupanic, E., von Euler, M., Kareholt, I., Contreras Escamez, B., Fastbom, J., Norrving, B., Religa, D., Kramberger, M. G., Winblad, B., Johnell, K., Eriksdotter, M., Garcia-Ptacek, S. October 7, 2017

Objective:

To compare access to intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) and its outcomes in patients with and without dementia.

Methods:

This was a longitudinal cohort study of the Swedish dementia and stroke registries. Patients with preexisting dementia who had AIS from 2010 to 2014 (n = 1,356) were compared with matched patients without dementia (n = 6,755).… Read More...

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