Abbas et al. examine the role of somatostatin and parvalbumin interneurons during spatial working memory. They find that somatostatin, but not parvalbumin, interneurons support working memory performance by facilitating hippocampal-prefrontal interactions and associated spatial encoding.
Rupprecht and Friedrich find that a transient balanced state is established in the zebrafish homolog of olfactory cortex during an odor response. The balance is maintained on short timescales (tight balance) and in stimulus space (detailed balance) and can stabilize activity patterns in coding space while preserving a high temporal bandwidth.… Read More...
Rohenkohl et al. show that visually induced interareal gamma synchronization between the primary and higher visual cortex occurs at the phase relation that optimally subserves stimulus transmission. This directly links interareal synchronization to behavior, strongly supporting the “Communication through Coherence” hypothesis.… Read More...
Ramesh, Burgess, and colleagues uncover intermingled ensembles of neurons in lateral visual association cortex that mostly track either stimulus identity or predicted outcome. Outcome-tracking, but not identity-tracking, neurons showed a response bias to food-predicting cues and sensitivity to reward history.
Divakaruni et al. showed that LTP induction prompts dendritic mitochondrial fission and mitochondrial Ca2+ transients (mCaTs), delineated a novel mechanism of activity-dependent fission regulation in neurons, and demonstrated that mCaTs and both structural and electrophysiological LTP require mitochondrial fission.
TBR1 directly regulates transcriptional circuits in heterozygous mutant mice that specify layer 6 identity and synapse number. As TBR1 is an ASD risk gene, our results provide insights into mechanisms that underlie ASD pathophysiology.
Jo et al. demonstrate that dopamine neurons of the ventral tegmental area encode the prediction of future threat. They demonstrate that elevated threat levels and increased uncertainty of threats induce fear generalization that is reflected in the dopamine code.
Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.