General Neurology

Atheir I. Abbas, Marina J.M. Sundiang, Britt Henoch, Mitchell P. Morton, Scott S. Bolkan, Alan J. Park, Alexander Z. Harris, Christoph Kellendonk, Joshua A. Gordon October 11, 2018

Abbas et al. examine the role of somatostatin and parvalbumin interneurons during spatial working memory. They find that somatostatin, but not parvalbumin, interneurons support working memory performance by facilitating hippocampal-prefrontal interactions and associated spatial encoding.

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Rohan N. Ramesh, Christian R. Burgess, Arthur U. Sugden, Michael Gyetvan, Mark L. Andermann October 11, 2018

Ramesh, Burgess, and colleagues uncover intermingled ensembles of neurons in lateral visual association cortex that mostly track either stimulus identity or predicted outcome. Outcome-tracking, but not identity-tracking, neurons showed a response bias to food-predicting cues and sensitivity to reward history.

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Sai Sachin Divakaruni, Adam M. Van Dyke, Ramesh Chandra, Tara A. LeGates, Minerva Contreras, Poorna A. Dharmasri, Henry N. Higgs, Mary Kay Lobo, Scott M. Thompson, Thomas A. Blanpied October 11, 2018

Divakaruni et al. showed that LTP induction prompts dendritic mitochondrial fission and mitochondrial Ca2+ transients (mCaTs), delineated a novel mechanism of activity-dependent fission regulation in neurons, and demonstrated that mCaTs and both structural and electrophysiological LTP require mitochondrial fission.

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Siavash Fazel Darbandi, Sarah E. Robinson Schwartz, Qihao Qi, Rinaldo Catta-Preta, Emily Lin-Ling Pai, Jeffrey D. Mandell, Amanda Everitt, Anna Rubin, Rebecca A. Krasnoff, Sol Katzman, David Tastad, Alex S. Nord, A. Jeremy Willsey, Bin Chen, Matthew W. State, Vikaas S. Sohal, John L.R. Rubenstein October 11, 2018

TBR1 directly regulates transcriptional circuits in heterozygous mutant mice that specify layer 6 identity and synapse number. As TBR1 is an ASD risk gene, our results provide insights into mechanisms that underlie ASD pathophysiology.

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Brie Wamsley, Xavier Hubert Jaglin, Emilia Favuzzi, Giulia Quattrocolo, Maximiliano José Nigro, Nusrath Yusuf, Alireza Khodadadi-Jamayran, Bernardo Rudy, Gord Fishell October 11, 2018

Wamsley et al. uncover a role of the splicing regulator Rbfox1 in promoting interneuron-specific connectivity in the developing neocortex. By differentially regulating alternative splicing profiles in PV+ and SST+ interneurons, Rbfox1 tailors their efferent connectivity.

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