General Neurology

van Veluw, S. J., Lauer, A., Charidimou, A., Bounemia, N., Xiong, L., Boulouis, G., Fotiadis, P., Ayres, A., Gurol, M. E., Viswanathan, A., Greenberg, S. M., Vernooij, M. W. October 26, 2017

Objective:

To address the pathophysiologic nature of small diffusion-weighted imaging (DWI) lesions in patients with cerebral amyloid angiopathy (CAA) who underwent serial MRI. Specifically, we tested (1) whether DWI lesions occurred preferentially in individuals with prior DWI lesions, (2) the cross-sectional association with chronic cortical cerebral microinfarcts (CMIs), and (3) the evolution of DWI lesions over time.… Read More...

Felix Fluri, Uwe Malzahn, György A. Homola, Michael K. Schuhmann, Christoph Kleinschnitz, Jens Volkmann October 24, 2017

Abstract

Objective: One-third of all stroke survivors are unable to walk, even after intensive physiotherapy. Thus, other concepts to restore walking are needed. Since electrical stimulation of the mesencephalic locomotor region (MLR) is known to elicit gait movements, this area might be a promising target for restorative neurostimulation in stroke patients with gait disability.

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Yi Gong, Nikhil Sasidharan, Fiza Laheji, Matthew Frosch, Patricia Musolino, Rudy Tanzi, Doo Yeon Kim, Alessandra Biffi, Joseph El Khoury, Florian Eichler October 24, 2017

Abstract

Objective: Mutations in ABCD1 cause the neurodegenerative disease adrenoleukodystrophy, which manifests as the spinal cord axonopathy adrenomyeloneuropathy (AMN) in nearly all males surviving into adulthood. Microglial dysfunction has long been implicated in pathogenesis of brain disease but its role in the spinal cord is unclear.

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admin October 23, 2017

ON THE COVER: A low magnification photomicrograph through the dorsal midbrain from a patient with clinical progressive supranuclear palsy due to underlying corticobasal degeneration, immunostained brown for hyperphosphorylated tau. Note the intense staining in the periaqueductal gray matter and overlying superior colliculus.

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Christopher Barbour, Peter Kosa, Mika Komori, Makoto Tanigawa, Ruturaj Masvekar, Tianxia Wu, Kory Johnson, Panagiotis Douvaras, Valentina Fossati, Ronald Herbst, Yue Wang, Keith Tan, Mark Greenwood, Bibiana Bielekova October 23, 2017

Abstract

Objective: Biomarkers aid diagnosis, allow inexpensive screening of therapies and guide selection of patient-specific therapeutic regimens in most internal medicine disciplines. In contrast, neurology lacks validated measurements of the physiological status, or dysfunction(s) of cells of the central nervous system (CNS).

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Mathilde Renaud, Christine Tranchant, Juan Vicente Torres Martin, Fanny Mochel, Matthis Synofzik, Bart van de Warrenburg, Massimo Pandolfo, Michel Koenig, Stefan A. Kolb, Mathieu Anheim, October 23, 2017

Abstract

Objective: Differential diagnosis of autosomal recessive cerebellar ataxias can be challenging. A ranking algorithm that predicts the molecular diagnosis based on the clinical phenotype of a patient has been developed to guide genetic testing and to align genetic findings with the clinical context.

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