General Neurology

admin June 15, 2019

A fluorescence photomicrograph showing the localization of JBTS17, a protein that organizes microtubules during cell division and which is mutated in Joubert syndrome. The nucleus of the cell is stained blue, the microtubules red and JBTS17 green. Note the localization of JBTS17 along the nuclear envelope and in the cytoplasm along microtubules.… Read More...

Sina Sangari, Henrik Lundell, Steven Kirshblum, Monica A. Perez June 15, 2019

Objective

Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). The neural mechanisms contributing to its development are not yet understood. Using neurophysiological and imaging techniques, we examined the influence of residual descending motor pathways on spasticity in humans with SCI.… Read More...

Juliane Gust, Olivia C. Finney, Daniel Li, Hannah M. Brakke, Roxana M. Hicks, Robert B. Futrell, Danielle N. Gamble, Stephanie D. Rawlings‐Rhea, Hedieh K. Khalatbari, Gisele E. Ishak, Virginia E. Duncan, Robert F. Hevner, Michael C. Jensen, Julie R. Park, Rebecca A. Gardner June 15, 2019

Objective

To test whether systemic cytokine release is associated with central nervous system inflammatory responses and glial injury in immune effector cell‐associated neurotoxicity syndrome (ICANS) after chimeric antigen receptor (CAR)‐T cell therapy in children and young adults.

Methods

We performed a prospective cohort study of clinical manifestations as well as imaging, pathology, CSF, and blood biomarkers on 43 subjects ages 1 to 25 who received CD19‐directed CAR/T cells for acute lymphoblastic leukemia (ALL).… Read More...

Colin A. Ellis, Leonid Churilov, Michael P. Epstein, Sharon X. Xie, Susannah T. Bellows, Ruth Ottman, Samuel F. Berkovic, for the Epi4K Consortium June 15, 2019

Objective

We tested 2 hypotheses regarding age at onset within familial epilepsies: (1) family members with epilepsy tend to have similar ages at onset, independent of epilepsy syndrome; and (2) age at onset is younger in successive generations after controlling for sampling bias.… Read More...

Serhiy Dekhtyar, Anna Marseglia, Weili Xu, Alexander Darin‐Mattsson, Hui‐Xin Wang, Laura Fratiglioni June 15, 2019

Objective

We investigated whether cognitive reserve modifies the risk of dementia attributable to apolipoprotein ε4 (APOE‐ε4), a well‐known genetic risk factor for dementia.

Methods

We followed 2,556 cognitively intact participants aged ≥60 years from the ongoing prospective community‐based Swedish National Study on Aging and Care in Kungsholmen (SNAC‐K).… Read More...

Marjolein M. Admiraal, Anne‐Fleur van Rootselaar, Jeannette Hofmeijer, Cornelia W. E. Hoedemaekers, Christiaan R. van Kaam, Hanneke M. Keijzer, Michel J. A. M. van Putten, Marcus J. Schultz, Janneke Horn June 15, 2019

Objective

Outcome prediction in patients after cardiac arrest (CA) is challenging. Electroencephalographic reactivity (EEG‐R) might be a reliable predictor. We aimed to determine the prognostic value of EEG‐R using a standardized assessment.

Methods

In a prospective cohort study, a strictly defined EEG‐R assessment protocol was executed twice per day in adult patients after CA.… Read More...

Laura A. Bonouvrié, Jules G. Becher, Johan S. H. Vles, R. Jeroen Vermeulen, Annemieke I. Buizer, on behalf of the IDYS Study Group June 15, 2019

Objective

Intrathecal baclofen treatment is used for the treatment of dystonia in patients with severe dyskinetic cerebral palsy; however, the current level of evidence for the effect is low. The primary aim of this study was to provide evidence for the effect of intrathecal baclofen treatment on individual goals in patients with severe dyskinetic cerebral palsy.… Read More...

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