Farías et al. report that the localization of the endoplasmic reticulum (ER) in the axon is controlled by the interaction between ER-shaping proteins and the microtubule cytoskeleton. Local ER and microtubule crosstalk promotes ER tubule-microtubule stabilization and drives neuronal polarity.
Shoji Yokobori, Kazuma Sasaki, Takahiro Kanaya, Yutaka Igarashi, Ryuta Nakae, Hidetaka Onda, Tomohiko Masuno, Satoshi Suda, Kota Sowa, Masataka Nakajima, Markus S. Spurlock, Lee Onn Chieng, Tom G. Hazel, Karl Johe, Shyam Gajavelli, Akira Fuse, M. Ross Bullock, Hiroyuki Yokota
Most brain functions require the selective and flexible routing of neuronal activity between cortical areas. Using paired population recordings from multiple visual cortical areas, Semedo et al. find a population-level mechanism that can achieve this routing, termed a communication subspace.