General Neurology

admin May 14, 2019

Acute encephalitis is a debilitating neurological disorder associated with brain inflammation and rapidly progressive encephalopathy. Autoimmune encephalitis (AE) is increasingly recognized as one of the most frequent causes of encephalitis, however signs of inflammation are not always present at the onset which may delay the diagnosis.… Read More...

Elizabeth N. Holly, M. Felicia Davatolhagh, Kyuhyun Choi, Opeyemi O. Alabi, Luigim Vargas Cifuentes, Marc V. Fuccillo May 13, 2019

The functional role of dorsomedial striatum low-threshold spiking interneurons (LTSIs) in behavior has been largely unexplored. Holly et al. show that LTSIs have reward outcome-associated activity that decreases with and causally modulates goal-directed learning.

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admin May 10, 2019

Emerging evidence suggests that Parkinson’s disease (PD) results from disrupted oscillatory activity in cortico-basal ganglia-thalamo-cortical (CBGTC) and cerebellar networks which can be partially corrected by applying deep brain stimulation (DBS). The inherent dynamic nature of such oscillatory activity might implicate that is represents temporal aspects of motor control.… Read More...

admin May 10, 2019

Proton magnetic resonance spectroscopy (MRS) provides a means of measuring cerebral metabolites in vivo relevant to neurodegeneration. In amyotrophic lateral sclerosis (ALS), neurochemical changes reflecting neuronal loss or dysfunction (decreased N-actylaspartate [NAA]) is most significant in the motor cortex and corticospinal tracts.… Read More...

admin May 10, 2019

BACKGROUND: While primary progressive aphasia (PPA) is associated with frontotemporal lobar degeneration (FTLD) pathology due to tau or TDP, clinical-pathological studies also demonstrate many cases have Alzheimer’s disease (AD) pathology. The logopenic variant of PPA (lvPPA) is most often associated with AD pathology, but this has proven to be the least reliable PPA to diagnose using published clinical criteria.… Read More...

Alejandra Fernandez, Daniel W. Meechan, Beverly A. Karpinski, Elizabeth M. Paronett, Corey A. Bryan, Hanna L. Rutz, Eric A. Radin, Noah Lubin, Erin R. Bonner, Anastas Popratiloff, Lawrence A. Rothblat, Thomas M. Maynard, Anthony-Samuel LaMantia May 9, 2019

Fernandez et al. use a mouse model of DiGeorge/22q11 deletion syndrome—a genetic neurodevelopmental disorder—to characterize biological mechanisms of neuronal under-connectivity, establish their role in higher-order behavior, and identify an effective pharmacological therapy.

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