General Neurology

Benjamin Hotter, Ivana Galinovic, Claudia Kunze, Peter Brunecker, Gerhard J. Jungehulsing, Arno Villringer, Matthias Endres, Kersten Villringer, Jochen B. Fiebach July 13, 2019

Abstract

Transient ischemic attack (TIA) is defined as focal neurological deficit caused by ischemia resolving within 24 hrs. In a secondary analysis of a large monocentric cohort of 446 TIA patients, we explored the frequency and determinants of DWI lesions on high‐resolution MRI.… Read More...

Varina L. Boerwinkle, Emilio G. Cediel, Lucia Mirea, Korwyn Williams, John F. Kerrigan, Sandi Lam, Jeffrey S. Raskin, Virendra R. Desai, Angus A. Wilfong, P. David Adelson, Daniel J. Curry July 12, 2019

Abstract

Objective

Postoperative resting state functional MRI in children with intractable epilepsy has not been quantified in relation to seizure outcome. Therefore, its value as a biomarker for epileptogenic pathology is not well understood.

Methods

In a sample of children with intractable epilepsy who underwent prospective resting state guided epilepsy surgery, post‐operative resting state functional MRI was performed 6 to 12 months later.… Read More...

Silvia Del Din, Morad Elshehabi, Brook Galna, Markus Hobert, Elke Warmerdam, Ulrike Suenkel, Kathrin Brockmann, Florian Metzger, Clint Hansen, Daniela Berg, Lynn Rochester, Walter Maetzler July 12, 2019

Abstract

OBJECTIVE

Quantification of gait with wearable technology is promising; recent cross‐sectional studies showed that gait characteristics are potential prodromal markers for Parkinson’s disease (PD). The aim of this longitudinal prospective observational study was to establish gait impairments and trajectories in the prodromal phase of PD, identifying which gait characteristics are potentially early diagnostic markers of PD.… Read More...

admin July 12, 2019

ABSTRACT:
Background and Purpose: Susceptibility-weighted imaging (SWI) has been emerged as a useful clinical tool in many neurological diseases including multiple sclerosis (MS). This study is to investigate the relationship between SWI signal changes including due to iron deposition in MS lesions and tissue blood perfusion and microstructural abnormalities to better understand their underlying histopathologies.… Read More...

admin July 12, 2019

Background: Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disorder characterized by degeneration of spinal motor neurons leading to muscular weakness. The antisense oligonucleotide nusinersen was approved for the treatment of patients with 5q-associated SMA. Treatment must be repeatedly administered intrathecally by lumbar puncture.… Read More...

Adrian R Parry‐Jones, Camilla Sammut‐Powell, Kyriaki Paroutoglou, Emily Birleson, Joshua Rowland, Stephanie Lee, Luca Cecchini, Mark Massyn, Richard Emsley, Benjamin Bray, Hiren Patel July 11, 2019

Abstract

Objective

Anticoagulation reversal, intensive blood pressure lowering, neurosurgery and access to critical care might all be beneficial in acute intracerebral hemorrhage (ICH). We combined and implemented these as the ‘ABC’ hyperacute care bundle and sought to determine whether the implementation was associated with lower case fatality.… Read More...

Matthew B. Bevers, Zoe Wolcott, Søren Bache, Christina Hansen, Cristina Sastre, Ravi Mylvaganam, Matthew J. Koch, Aman B. Patel, Kirsten Møller, W. Taylor Kimberly July 11, 2019

Abstract

Objective

To investigate whether soluble ST2, a prognostic marker in cardiovascular and inflammatory disorders, is associated with neurological injury after aneurysmal subarachnoid hemorrhage (SAH).

Methods

We studied SAH patients from two independent cohorts. Outcome assessments included functional status at 90 days using the modified Rankin Scale (mRS), mortality, and delayed cerebral ischemia (DCI).… Read More...

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