General Neurology

Divyanshu Dubey, Jeffrey Britton, Andrew McKeon, Avi Gadoth, Anastasia Zekeridou, Sebastian A Lopez Chiriboga, Michelle Devine, Jane H. Cerhan, Katie Dunlay, Jessica Sagen, Melanie Ramberger, Patrick Waters, Sarosh R Irani, Sean J. Pittock November 29, 2019

Abstract

Objective

Drug‐resistant seizures are common in patients with Leucine‐rich, glioma‐inactivated‐1 (LGI1) and contactin‐associated‐protein‐like‐2 (CASPR2)‐IgG associated encephalitis. We performed the first randomized double‐blind placebo‐controlled trial to evaluate efficacy of intravenous immunoglobulin (IVIG) in reducing seizure frequency.

Methods

Our enrollment goal was 30 LGI1/CASPR2‐IgG‐seropositive adult patients with ≥2 seizures per‐week.… Read More...

Nicolás Ellenrieder, Jean Gotman, Rina Zelmann, Christine Rogers, Dang Khoa Nguyen, Philippe Kahane, François Dubeau, Birgit Frauscher November 29, 2019

ABSTRACT

Objective

Regional variations in oscillatory activity during human sleep remain unknown. Using the unique ability of intracranial electroencephalography to study in‐situ brain physiology, this study assesses regional variations of electroencephalographic sleep activity and creates the first atlas of human sleep using recordings from the first sleep cycle.… Read More...

admin November 28, 2019

Fast activities (FA) at seizure onset have been increasingly described as a useful signature of the epileptogenic zone (EZ) in patients undergoing intracranial EEG recordings. Different computer-based signal analysis methods have thus been developed for objectively quantifying ictal FA. Whether these methods detect FA in all forms of focal epilepsies, whether they provide similar information than visual analysis (VA), and whether they might help for the surgical decision remain crucial issues.… Read More...

admin November 28, 2019

Background: X-linked dystonia parkinsonism (XDP) is a neurodegenerative disease endemic to Filipinos with maternal lineage from Panay Island, Philippines. Patients present with dystonia concurrent with or followed by parkinsonism. Non-motor symptoms also predominate, affecting behavior and cognition. We aimed to translate and do cross-cultural adaptation and validation of the Montreal Cognitive Assessment Tool (MoCA) into Hiligaynon (MoCA-Hil), the language spoken in Panay Island, to perform baseline cognitive screening of XDP patients.… Read More...

admin November 28, 2019

Background: External ventricular drainage (EVD) is common after brain surgery. However, the incidence of EVD-related infection (ERI) is still relatively high and can increase morbidity and mortality.

Objective: The objective of this study was to analyze ERI factors in pediatric population post-brain tumor surgery.… Read More...

Junko Ito, Hiroshi Shimizu, Kentaro Ohta, Jiro Idezuka, Hajime Tanaka, Hiroshi Kondo, Takashi Nakajima, Hitoshi Takahashi, Kohei Akazawa, Osamu Onodera, Akiyoshi Kakita November 27, 2019

Abstract

Objective

The pallido‐nigro‐luysian (PNL) system, the primary component of cortico‐subcortical circuits, is generally spared in amyotrophic lateral sclerosis (ALS). We evaluated the clinicopathological features of an unusual form of ALS with PNL degeneration (PNLD) and assessed whether ALS with PNLD represents a distinct ALS subtype.… Read More...

Harris S. Kaplan, Oriana Salazar Thula, Niklas Khoss, Manuel Zimmer November 27, 2019

The nervous system must coordinate behavior across several timescales. A decades-old hypothesis in ethology posits that this occurs via hierarchical control. Kaplan et al. show that C. elegans employs hierarchically nested neuronal dynamics across brain and motor circuits to implement such multi-timescale behavioral organization.… Read More...

Chao Yang, Xu Wang, Jianying Wang, Xuejie Wang, Weitao Chen, Na Lu, Symeon Siniossoglou, Zhongping Yao, Kai Liu November 27, 2019

Axotomy alters several glycerolipid biosynthetic enzymes to regulate axon regeneration in both CNS and PNS neurons. Depleting neuronal lipin1 and DGAT to redirect lipid synthesis away from triglycerides and toward phospholipids promotes axon regeneration.

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Alex H. Williams, Ben Poole, Niru Maheswaranathan, Ashesh K. Dhawale, Tucker Fisher, Christopher D. Wilson, David H. Brann, Eric M. Trautmann, Stephen Ryu, Roman Shusterman, Dmitry Rinberg, Bence P. Ölveczky, Krishna V. Shenoy, Surya Ganguli November 27, 2019

The timing of neural dynamics can be highly variable across trials due to uncontrolled behavioral variability or unobserved cognitive states. Williams et al. describe an interpretable statistical model to control for these misalignments and use this approach to uncover fine-scale temporal structure that is imperceptible in raw data.… Read More...

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