Headaches

Hsiangkuo Yuan, Stephen D. Silberstein September 3, 2017

Background

Histamine is an ancient “tissue amine” preceding multicellular organisms. In the central nervous system (CNS), its fibers originate solely from the tuberomammillary nucleus and travel throughout the brain. It is mainly responsible for wakefulness, energy homeostasis, and memory consolidation. Recently, several studies suggest a potential role of histamine in migraine pathogenesis and management.

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Joshua M. Cohen, David W. Dodick, Ronghua Yang, Lawrence C. Newman, Thomas Li, Ernesto Aycardi, Marcelo E. Bigal September 3, 2017

Background

Fremanezumab (formerly TEV-48125) is a monoclonal antibody directed against calcitonin-gene-related peptide (CGRP), a validated target for migraine preventive therapy. In two previous phase 2 studies, fremanezumab administered once every 28 days for 12 weeks was found to be effective and safe as a preventive treatment for patients suffering from episodic migraine (EM) and chronic migraine (CM).

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