Movement Disorders

Chin‐Hsien Lin, Pei‐Lung Chen, Chun‐Hwei Tai, Hang‐I Lin, Chih‐Shan Chen, Meng‐Ling Chen, Ruey‐Meei Wu February 21, 2019

Abstract

Background

Recent genetic progress has allowed for the molecular diagnosis of Parkinson’s disease. However, genetic causes of PD vary widely in different ethnicities. Mutational frequencies and clinical phenotypes of genes associated with PD in Asian populations are largely unknown. The objective of this study was to identify the mutational frequencies and clinical spectrums of multiple PD‐causative genes in a Taiwanese PD cohort.… Read More...

Aya Ikeda, Hitoshi Shimada, Kenya Nishioka, Masashi Takanashi, Arisa Hayashida, Yuanzhe Li, Hiroyo Yoshino, Manabu Funayama, Yuji Ueno, Taku Hatano, Naruhiko Sahara, Tetsuya Suhara, Makoto Higuchi, Nobutaka Hattori February 18, 2019

ABSTRACT

Background

While mechanistic links between tau abnormalities and neurodegeneration have been proven in frontotemporal dementia and parkinsonism linked to chromosome 17 caused by MAPT mutations, variability of the tau pathogenesis and its relation to clinical progressions in the same MAPT mutation carriers are yet to be clarified.… Read More...

Antonio de Iure, Francesco Napolitano, Goichi Beck, Ana Quiroga Varela, Valentina Durante, Miriam Sciaccaluga, Petra Mazzocchetti, Alfredo Megaro, Michela Tantucci, Antonella Cardinale, Daniela Punzo, Andrea Mancini, Cinzia Costa, Veronica Ghiglieri, Alessandro Tozzi, Barbara Picconi, Stella M. Papa, Alessandro Usiello, Paolo Calabresi February 14, 2019

ABSTRACT

Objective

Spreading depolarization (SD) is a transient self‐propagating wave of neuronal and glial depolarization coupled with large membrane ionic changes and a subsequent depression of neuronal activity. Spreading depolarization in the cortex is implicated in migraine, stroke, and epilepsy. Conversely, spreading depolarization in the striatum, a brain structure deeply involved in motor control and in Parkinson’s disease (PD) pathophysiology, has been poorly investigated.… Read More...

Yong‐Sook Park, Na Young Jung, Young Cheol Na, Jin Woo Chang February 14, 2019

Abstract

Background

Following the emergence of magnetic resonance‐guided focused ultrasound as a promising tool for movement disorder surgery, thalamotomy for essential tremor using this technique has become a useful tool based on its efficacy and lack of adverse effects. Here, we summarize the 4‐year results of previous reports focusing on the durability of effectiveness of magnetic resonance‐guided focused ultrasound thalamotomy for essential tremor.… Read More...

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