Movement Disorders

Joanne Trinh, Katja Lohmann, Hauke Baumann, Alexander Balck, Max Borsche, Norbert Brüggemann, Leon Dure, Marissa Dean, Jens Volkmann, Sinem Tunc, Jannik Prasuhn, Heike Pawlack, Sophie Imhoff, Christina M. Lill, Meike Kasten, Peter Bauer, Arndt Rolfs, International Parkinson's Disease Genomics Consortium (IPDGC), Christine Klein December 11, 2018

ABSTRACT

Background: Although the genetic load is high in early‐onset Parkinson’s disease, thorough investigation of the genetic diagnostic yield has yet to be established. The objectives of this study were to assess variants in known genes for PD and other movement disorders and to find new candidates in 50 patients with early‐onset PD.… Read More...

Helena Bejr‐kasem, Javier Pagonabarraga, Saül Martínez‐Horta, Frederic Sampedro, Juan Marín‐Lahoz, Andrea Horta‐Barba, Ignacio Aracil‐Bolaños, Jesús Pérez‐Pérez, M. Ángeles Botí, Antonia Campolongo, Cristina Izquierdo, Berta Pascual‐Sedano, Beatriz Gómez‐Ansón, Jaime Kulisevsky December 11, 2018

Abstract

Background

Minor hallucinations and well‐structured hallucinations are considered in the severity continuum of the psychotic spectrum associated with Parkinson’s disease. Although their chronological relationship is largely unknown, the spatial patterns of brain atrophy in these 2 forms of hallucinations partially overlap, suggesting they share similar pathophysiological processes.… Read More...

Fatma Gargouri, Cécile Gallea, Marie Mongin, Nadya Pyatigorskaya, Romain Valabregue, Claire Ewenczyk, Marie Sarazin, Lydia Yahia‐Cherif, Marie Vidailhet, Stéphane Lehéricy December 11, 2018

ABSTRACT

Background: Cognitive deficits in Parkinson’s disease (PD) may result from damage in the cortex as well as in the dopaminergic, noradrenergic, and cholinergic inputs to the cortex. Cholinergic inputs to the cortex mainly originate from the basal forebrain and are clustered in several regions, called Ch1 to Ch4, that project to the hippocampus (Ch1‐2), the olfactory bulb (Ch3), and the cortex and amygdala (Ch4).… Read More...

Verónica Martínez Cerdeño, Tiffany Hong, Sarwat Amina, Mirna Lechpammer, Jeanelle Ariza, Flora Tassone, Stephen C. Noctor, Paul Hagerman, Randi Hagerman December 11, 2018

ABSTRACT

Background

Fragile X‐associated tremor/ataxia syndrome (FXTAS) is a late‐onset neurodegenerative disorder associated with premutation alleles of the FMR1 gene. Expansions of more than 200 CGG repeats give rise to fragile X syndrome, the most common inherited form of cognitive impairment.… Read More...

Taylor R. Hendershott, Delphine Zhu, Seoni Llanes, Cyrus P. Zabetian, Joseph Quinn, Karen L. Edwards, James B. Leverenz, Thomas Montine, Brenna Cholerton, Kathleen L. Poston December 11, 2018

Abstract

Background

Clinicians and researchers commonly use global cognitive assessments to screen for impairment. Currently there are no published studies directly comparing the sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale‐2 in PD. The objective of this study was to identify the relative sensitivity and specificity of the Montreal Cognitive Assessment and Mattis Dementia Rating Scale‐2 in PD.… Read More...

Max‐Philipp Stenner, Charlotte Baumgaertel, Hans‐Jochen Heinze, Christos Ganos, Kirsten R. Müller‐Vahl November 29, 2018

Abstract

Background: Behavioral disinhibition has been proposed as a key mechanism in Tourette syndrome. Yet classic inhibition tasks have yielded inconsistent results, likely reflecting interference by strategies compensating for tic release.

Methods: We examined a core inhibitory function that is immune to such interference because it suppresses movements automatically.… Read More...

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