Movement Disorders

Daniel Weintraub, Lana M. Chahine, Keith A. Hawkins, Andrew Siderowf, Shirley Eberly, David Oakes, John Seibyl, Matthew B. Stern, Kenneth Marek, Danna Jennings, October 24, 2017

ABSTRACT

Background

Prospective data on cognition in prodromal Parkinson’s disease are limited. The objectives of this study were to assess in prodromal PD (1) if baseline cognition predicts conversion to clinical PD, (2) if baseline dopamine transporter binding predicts longitudinal changes in cognition, and (3) if impaired olfaction predicts future cognitive decline.

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Sophie Fengler, Inga Liepelt-Scarfone, Kathrin Brockmann, Eva Schäffer, Daniela Berg, Elke Kalbe October 5, 2017

Abstract

Although other nonmotor phenomena representing possible prodromal symptoms of Parkinson’s disease have been described in some detail, the occurrence and characteristics of cognitive decline in this early phase of the disease are less well understood. The aim of this review is to summarize the current state of research on cognitive changes in prodromal PD.

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Kristin J. Ford, Allen Joop, Raima A. Memon, Kimberly H. Wood, Karlene Ball, Gary R. Cutter, David C. Schwebel, Amy W. Amara October 4, 2017

ABSTRACT

Background

Patients with Parkinson’s disease experience debilitating motor symptoms as well as nonmotor symptoms, such as cognitive dysfunction and sleep disorders. This constellation of symptoms has the potential to negatively influence pedestrian safety. The objective of this study was to investigate the association of motor symptoms, daytime sleepiness, impaired vigilance, and cognitive dysfunction with pedestrian behavior in patients with Parkinson’s disease and healthy older adults.

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Angus D. Macleod, Ingvild Dalen, Ole-Bjørn Tysnes, Jan Petter Larsen, Carl E. Counsell October 4, 2017

ABSTRACT

Objective

The objective of this study was to develop valid prognostic models to predict mortality, dependency, and “death or dependency” for use in newly diagnosed Parkinson’s disease (PD).

Methods

The models were developed in the Parkinsonism Incidence in North-East Scotland study (UK, 198 patients) and validated in the ParkWest study (Norway, 192 patients), cohorts that attempted to identify and follow-up all new PD cases in the study area.

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