Movement Disorders

Wesley Thevathasan, Bettina Debu, Tipu Aziz, Bastiaan R. Bloem, Christian Blahak, Christopher Butson, Virginie Czernecki, Thomas Foltynie, Valerie Fraix, David Grabli, Carole Joint, Andres M. Lozano, Michael S. Okun, Jill Ostrem, Nicola Pavese, Christoph Schrader, Chun-Hwei Tai, Joachim K. Krauss, Elena Moro, September 28, 2017

ABSTRACT

Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but experimental therapy for axial motor deficits in Parkinson’s disease (PD), particularly gait freezing and falls. Here, we summarise the clinical application and outcomes reported during the past 10 years.

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Roberta Biundo, Luca Weis, Giovanni Abbruzzese, Giovanna Calandra-Buonaura, Pietro Cortelli, Maria Cristina Jori, Leonardo Lopiano, Roberto Marconi, Angela Matinella, Francesca Morgante, Alessandra Nicoletti, Tiziano Tamburini, Michele Tinazzi, Mario Zappia, Ruxandra Julia Vorovenci, Angelo Antonini September 27, 2017

Abstract

Background

Impulse control disorders and dyskinesia are common and disabling complications of dopaminergic treatment in Parkinson’s disease. They may coexist and are possibly related. The objectives of this study were to assess the frequency and severity of impulse control disorders in Parkinson’s disease patients with dyskinesia.

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Koji Kasanuki, Michael G. Heckman, Nancy N. Diehl, Melissa E. Murray, Shunsuke Koga, Alexandra Soto, Owen A. Ross, Dennis W. Dickson September 26, 2017

ABSTRACT

Background

A number of genetic loci are associated with risk for Parkinson’s disease (PD) based on genome-wide association studies; however, the relationship between genetic variants and nigrostriatal degeneration, which is the structural correlate of parkinsonism, has not been reported.

Objectives

We quantified nigrostriatal dopaminergic integrity with image analysis of putaminal tyrosine hydroxylase immunoreactivity in 492 brains with Lewy body disease and used this pathologic endophenotype to explore possible association with PD genetic variants.

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Alessandro Tessitore, Rosa De Micco, Alfonso Giordano, Federica di Nardo, Giuseppina Caiazzo, Mattia Siciliano, Manuela De Stefano, Antonio Russo, Fabrizio Esposito, Gioacchino Tedeschi September 26, 2017

Abstract

Background: Impulse control disorders can be triggered by dopamine replacement therapies in patients with PD. Using resting-state functional MRI, we investigated the intrinsic brain network connectivity at baseline in a cohort of drug-naive PD patients who successively developed impulse control disorders over a 36-month follow-up period compared with patients who did not.

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Samuel J. Rose, Porter Harrast, Christine Donsante, Xueliang Fan, Valerie Joers, Malú G. Tansey, H.A. Jinnah, Ellen J. Hess September 26, 2017

Abstract

Background: Recent neuroimaging studies implicate nigrostriatal degeneration as a critical factor in producing late-onset parkinsonism in patients with l-dopa-responsive dystonia-causing mutations. However, postmortem anatomical studies do not reveal neurodegeneration in l-dopa-responsive dystonia patients. These contrasting findings make it unclear how parkinsonism develops in l-dopa-responsive dystonia mutation carriers.

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