Movement Disorders

Barbara Picconi, Ledia F. Hernández, Jose A. Obeso, Paolo Calabresi December 9, 2017

ABSTRACT

Long-term levodopa (l-dopa) treatment in patients with Parkinson´s disease (PD) is associated with the development of motor complications (ie, motor fluctuations and dyskinesias). The principal etiopathogenic factors are the degree of nigro-striatal dopaminergic loss and the duration and dose of l-dopa treatment.

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Jennifer G. Goldman, Howard Andrews, Amy Amara, Anna Naito, Roy N. Alcalay, Leslie M. Shaw, Peggy Taylor, Tao Xie, Paul Tuite, Claire Henchcliffe, Penelope Hogarth, Samuel Frank, Marie-Helene Saint-Hilaire, Mark Frasier, Vanessa Arnedo, Alyssa N. Reimer, Margaret Sutherland, Christine Swanson-Fischer, Katrina Gwinn, Un Jung Kang December 4, 2017

ABSTRACT

Objective: Examine relationships among neurodegenerative biomarkers and PD motor and nonmotor symptoms.

Background: CSF alpha-synuclein is decreased in PD versus healthy controls, but whether plasma and saliva alpha-synuclein differentiate these groups is controversial. Correlations of alpha-synuclein among biofluids (CSF, plasma, saliva) or biomarkers (eg, beta-amyloid, tau [total, phosphorylated]) are not fully understood.

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