Movement Disorders

Giulia Ponterio, Annalisa Tassone, Giuseppe Sciamanna, Valentina Vanni, Maria Meringolo, Massimo Santoro, Nicola Biagio Mercuri, Paola Bonsi, Antonio Pisani November 18, 2017

ABSTRACT

Background: Mu opioid receptor activation modulates acetylcholine release in the dorsal striatum, an area deeply involved in motor function, habit formation, and reinforcement learning as well as in the pathophysiology of different movement disorders, such as dystonia. Although the role of opioids in drug reward and addiction is well established, their involvement in motor dysfunction remains largely unexplored.

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Kaylena A. Ehgoetz Martens, Emily L. Lukasik, Matthew J. Georgiades, Moran Gilat, Julie M. Hall, Courtney C. Walton, Simon J.G. Lewis November 18, 2017

ABSTRACT

Background: Freezing of gait is a disabling symptom of Parkinson’s disease that ultimately affects approximately 80% of patients, yet very little research has focused on predicting the onset of freezing of gait and tracking the longitudinal progression of symptoms prior to its onset.

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Marta Ruiz-Lopez, Alfonso Fasano November 16, 2017

ABSTRACT

Status dystonicus is a movement disorder emergency that has been a source of controversy in terms of terminology, phenomenology, and management since it was first described in 1982. Here we argue that the current use of the term status dystonicus falls well short of the precision needed for either clinical or academic use.

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