Multiple Sclerosis

Aarushi Jain October 18, 2019

Multiple Sclerosis Journal, Ahead of Print.
Wilhelm Uhthoff, known for his contributions to both neurology and neuro-ophthalmology, was a German ophthalmologist who specialized in neurologic disorders. The eponym “Uhthoff’s phenomenon” was first used to describe the reversible, transient blurring of vision in patients with multiple sclerosis during exercise.… Read More...

Sverker Johansson October 18, 2019

Multiple Sclerosis Journal, Ahead of Print.
Background:Identification of people with multiple sclerosis (PwMS) with increased risk of restricted participation in social and lifestyle activities (e.g. social outings and pursuing a hobby) could guide the development of interventions supporting sustained participation.Objective:To explore changes in participation in complex and social everyday activities over 10 years in PwMS in relation to multiple sclerosis (MS) severity and to identify predictors of sustained participation.Methods:This study was based on a 10-year follow-up of 264 PwMS living in Stockholm County, Sweden.… Read More...

Jorge U Máñez-Miró October 17, 2019

Multiple Sclerosis Journal, Ahead of Print.
Multiple sclerosis (MS)-related tremor is frequent and can often be refractory to medical treatment, which makes it a potential source of major disability. Functional neurosurgery approaches such as thalamic deep brain stimulation (DBS) or radiofrequency thalamotomy are proven to be effective, but the application of invasive techniques in MS tremor has so far been limited.… Read More...

Mar Tintore October 15, 2019

Multiple Sclerosis Journal, Ahead of Print.
Objective:To explore the long-term outcomes of patients with clinically isolated syndromes from the Barcelona cohort.Methods:We selected patients with a follow-up longer than 10 years to (1) estimate the risks of multiple sclerosis (MS) and disability accumulation according to the baseline number of T2 lesions and to compare treated versus untreated patients and early versus delayed treatment, and (2) to study baseline features of patients with aggressive MS (Expanded Disability Status Scale (EDSS) ⩾6.0 at 10 years).Results:In all, 401 patients were included (mean follow-up of 14.4 (standard deviation of 2.9) years).… Read More...

Dejan Jakimovski October 15, 2019

Multiple Sclerosis Journal, Ahead of Print.
Background:A limited number of studies investigated associations between serum neurofilament light chain (sNfL) and cognition in persons with multiple sclerosis (PwMS).Objective:To assess cross-sectional and longitudinal associations between sNfL levels, clinical, and cognitive performance in PwMS and age-matched healthy controls (HCs).Materials:One hundred twenty-seven PwMS (85 relapsing–remitting MS/42 progressive MS), 20 clinically isolated syndrome patients, and 52 HCs were followed for 5 years.… Read More...

Alfredo Damasceno October 11, 2019

Multiple Sclerosis Journal, Ahead of Print.
Background:Information concerning longitudinal cognitive trajectories in multiple sclerosis (MS) is relatively scarce. Moreover, it is unclear which factors are associated with cognitive decline and what is the clinical impact of cognitive impairment (CI) in the long run.Objective:To investigate cognitive trajectories in relapsing–remitting multiple sclerosis (RRMS) patients, analyzing clinical and magnetic resonance imaging (MRI) predictors of cognitive decline.Methods:We enrolled 42 patients and 30 controls.… Read More...

Chiara Zecca October 2, 2019

Multiple Sclerosis Journal, Ahead of Print.
Background:Rituximab, an anti-CD20 monoclonal antibody leading to B lymphocyte depletion, is increasingly used as an off-label treatment option for multiple sclerosis (MS).Objective:To investigate the effectiveness and safety of rituximab in relapsing–remitting (RR) and progressive MS.Methods:This is a multicenter, retrospective study on consecutive MS patients treated off-label with rituximab in 22 Italian and 1 Swiss MS centers.… Read More...

Mehrnaz Ighani October 2, 2019

Multiple Sclerosis Journal, Ahead of Print.
Background:Autopsy data suggest a causative link between meningeal inflammation and cortical lesions (CLs) in multiple sclerosis (MS).Objective:To use leptomeningeal enhancement (LME) and CLs on 7-Tesla (7T) magnetic resonance imaging (MRI) to investigate associations between meningeal inflammation and cortical pathology.Methods:Forty-one participants with MS underwent 7T MRI of the brain.… Read More...

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