Neuropathology

admin January 20, 2019

Abstract

Microglia nodule formation is a common feature in inflammatory brain diseases mediated by T lymphocytes such as viral and paraneoplastic encephalitis, multiple sclerosis, and Rasmussen encephalitis (RE). However, its role has not been fully understood yet. We hypothesized that, in RE, microglial nodules provide an environment for the initiation of the later dominating T-cell cytotoxicity.… Read More...

Haiyan An, Lucy Skelt, Antonietta Notaro, J. Robin Highley, Archa H. Fox, Vincenzo La Bella, Vladimir L. Buchman and Tatyana A. Shelkovnikova January 14, 2019

Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). Mutant FUS is known to confer cytoplasmic gain of function but its effects in the nucleus are less understood. FUS is an essential componen…

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