Neuropathology

Emilie L. Castranio, Cody M. Wolfe, Kyong Nyon Nam, Florent Letronne, Nicholas F. Fitz, Iliya Lefterov and Radosveta Koldamova July 27, 2018

Expression of human Apolipoprotein E (APOE) modulates the inflammatory response in an isoform specific manner, with APOE4 isoform eliciting a stronger pro-inflammatory response, suggesting a possible mechanism fo…

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admin July 25, 2018

Abstract

Parkinson’s disease (PD), the most common neurodegenerative movement disorder, is characterized by the progressive loss of nigral dopamine neurons. The deposition of fibrillary aggregated α-synuclein in Lewy bodies (LB), that is considered to play a causative role in the disease, constitutes another key neuropathological hallmark of PD.… Read More...

Andrea B. Ganz, Nina Beker, Marc Hulsman, Sietske Sikkes, Netherlands Brain Bank, Philip Scheltens, August B. Smit, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans and Henne Holstege July 24, 2018

With aging, the incidence of neuropathological hallmarks of neurodegenerative diseases increases in the brains of cognitively healthy individuals. It is currently unclear to what extent these hallmarks associa…

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Christina E. Murray, Priya Gami-Patel, Eleni Gkanatsiou, Gunnar Brinkmalm, Erik Portelius, Oliver Wirths, Wendy Heywood, Kaj Blennow, Jorge Ghiso, Janice L. Holton, Kevin Mills, Henrik Zetterberg, Tamas Revesz and Tammaryn Lashley July 21, 2018

In the majority of affected brain regions the pathological hallmarks of Alzheimer’s disease (AD) are β-amyloid (Aβ) deposits in the form of diffuse and neuritic plaques, tau pathology in the form of neurofibri…

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Nobutaka Sakae, Kevin F. Bieniek, Yong-Jie Zhang, Kelly Ross, Tania F. Gendron, Melissa E. Murray, Rosa Rademakers, Leonard Petrucelli and Dennis W. Dickson July 21, 2018

Frontotemporal lobar degeneration (FTLD) is heterogeneous in clinical presentation, neuropathological characteristics and genetics. An expanded GGGGCC hexanucleotide repeat in C9ORF72 is the most common genetic c…

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