Stroke

Nobukazu Miyamoto, Ryota Tanaka, Yuji Ueno, Masao Watanabe, Naohide Kurita, Kenichiro Hira, Yoshiaki Shimada, Takuma Kuroki, Kazuo Yamashiro, Takao Urabe, Nobutaka Hattori September 4, 2017

Early neurological worsening is associated with increased mortality and long-term functional disability. We developed the WORSEN score for predicting whether patients with stroke will deteriorate during the week after stroke onset and investigated its usefulness.

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Elaine M. Bochniewicz, Geoff Emmer, Adam McLeod, Jessica Barth, Alexander W. Dromerick, Peter Lum September 4, 2017

Trials of restorative therapies after stroke and clinical rehabilitation require relevant and objective efficacy end points; real-world upper extremity (UE) functional use is an attractive candidate. We present a novel, inexpensive, and feasible method for separating UE functional use from nonfunctional movement after stroke using a single wrist-worn accelerometer.… Read More...

Hao Zhang, Xiaoou Sun, Yanxiang Xie, Jie Zan, Wen Tan September 4, 2017

Isosteviol sodium (STVNa) has been reported to have neuroprotective effects against ischemia/reperfusion (I/R) injury in rats. Furthermore, recanalization treatments, including thrombolytic therapy, have several limitations. Excessive inflammation and apoptosis contribute to the pathogenesis of ischemic brain damage. Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is critical to these processes and is associated with cerebral ischemia.… Read More...

Siyi Chen, Laura Bennet, Ailsa L. McGregor September 4, 2017

Pharmacological activation of the cholinergic anti-inflammatory pathway (CAP), specifically by activating α7 nicotinic acetylcholine receptors, has been shown to confer short-term improvements in outcome. Most studies have investigated administration within 24 hours of stroke, and few have investigated drugs approved for use in human patients.… Read More...

Yuki Shinya, Satoru Miyawaki, Hideaki Imai, Hiroki Hongo, Hideaki Ono, Atsumi Takenobu, Hirofumi Nakatomi, Akira Teraoka, Nobuhito Saito September 4, 2017

Intracranial atherosclerosis of the anterior circulation (anterior ICAS) and intracranial atherosclerosis of the posterior circulation (posterior ICAS) are thought to involve different pathogeneses and risk factors. Recently, we identified a genetic variant that has a significant association with ICAS. The variant was ring finger protein 213 (RNF213) c.14576GA (rs112735431), which was originally identified as a susceptibility genetic variant for moyamoya disease (MMD).… Read More...

Hidetaka Arishima, Hiroyuki Neishi, Ken-ichiro Kikuta, Mihoko Morita, Naoko Hosono, Takahiro Yamauchi, Masayoshi Souri, Akitada Ichinose September 4, 2017

A 68-year-old man presented with intracranial hemorrhage in the right frontal lobe, which rapidly increased the day after admission. We performed hematoma removal with a biopsy of the cortex around the hematoma. The day after the operation, a subcutaneous hematoma over the craniotomy appeared, and the computed tomography showed a recurrent hemorrhage with an acute subdural hematoma.… Read More...

Chun-An Cheng, Chun-Gu Cheng, Jiuun-Tay Lee, Hung-Che Lin, Cheng-Chung Cheng, Hung-Wen Chiu September 4, 2017

Sepsis increases the long-term incidence of ischemic stroke (IS). The chances for long-term IS in patients who are discharged after sepsis are unclear. Our aim was to demonstrate long-term risk chances of IS after septicemia discharge. We used a nomogram to identify those septicemia survivors with the higher risk of developing IS.… Read More...

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